Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells.
Wu KH, Lee WJ, Cheng TC, Chang HW, Chen LC, Chen CC, Lien HM, Lin TN, Ho YS.
BMC Complement Altern Med. 2019 Jul 27;19(1):188. doi: 10.1186/s12906-019-2590-9.

Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats.
Ajebli M, Eddouks M.
J Ethnopharmacol. 2019 Oct 5;242:112039. doi: 10.1016/j.jep.2019.112039.

In vitro anti-nephrotoxic potential of Ammi visnaga, Petroselinum crispum, Hordeum vulgare, and Cymbopogon schoenanthus seed or leaf extracts by suppressing the necrotic mediators, oxidative stress and inflammation.
Abu-Serie MM, Habashy NH, Maher AM.
BMC Complement Altern Med. 2019 Jun 25;19(1):149. doi: 10.1186/s12906-019-2559-8.

Biochemical Effects of Petroselinum crispum (Umbellifereae) Essential Oil on the Pyrethroid Resistant Strains of Aedes aegypti (Diptera: Culicidae).
Intirach J, Junkum A, Lumjuan N, Chaithong U, Somboon P, Jitpakdi A, Riyong D, Champakaew D, Muangmoon R, Chansang A, Pitasawat B.
Insects. 2018 Dec 24;10(1). pii: E1. doi: 10.3390/insects10010001.

The Effects of Petroselinum Crispum on Estrogen Receptor-positive Benign and Malignant Mammary Cells (MCF12A/MCF7).
Schröder L, Koch J, Mahner S, Kost BP, Hofmann S, Jeschke U, Haumann J, Schmedt J, Richter DU.
Anticancer Res. 2017 Jan;37(1):95-102

The Effect of Topical Use of Petroselinum Crispum (Parsley) Versus That of Hydroquinone Cream on Reduction of Epidermal Melasma: A Randomized Clinical Trial.
Khosravan S, Alami A, Mohammadzadeh-Moghadam H, Ramezani V.
Holist Nurs Pract. 2017 Jan/Feb;31(1):16-20.

Antimosquito property of Petroselinum crispum (Umbellifereae) against the pyrethroid resistant and susceptible strains of Aedes aegypti (Diptera: Culicidae).
Intirach J, Junkum A, Lumjuan N, Chaithong U, Jitpakdi A, Riyong D, Wannasan A, Champakaew D, Muangmoon R, Chansang A, Pitasawat B.
Environ Sci Pollut Res Int. 2016 Dec;23(23):23994-24008.

Antifungal and antibacterial activities of Petroselinum crispum essential oil.
Linde GA, Gazim ZC, Cardoso BK, Jorge LF, Tešević V, Glamoćlija J, Soković M, Colauto NB.
Genet Mol Res. 2016 Jul 29;15(3). doi: 10.4238/gmr.15038538.

Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats.
Hozayen WG, El-Desouky MA, Soliman HA, Ahmed RR, Khaliefa AK.
BMC Complement Altern Med. 2016 Jun 2;16:165. doi: 10.1186/s12906-016-1140-y.

Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus).
Maodaa SN, Allam AA, Ajarem J, Abdel-Maksoud MA, Al-Basher GI, Wang ZY.
Behav Brain Funct. 2016 Feb 4;12(1):6. doi: 10.1186/s12993-016-0090-3.     

Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet.
Nair VY, Balakrishanan N, Antony Santiago JV.
Bratisl Lek Listy. 2015;116(9):547-53.

Parsley (Petroselinum crispum) is a very common herb, belonging to the Umbelliferae family, widespread in the Mediterranean countries, western Asia and in many temperate climate regions.

It is used in the food industry, in soaps, perfume creams.

Its components flavonoids, coumarin, tocopherol, carotenoids and ascorbic acid give this herb antioxidant, anti-inflammatory and antihypertensive activity.

Vitamin C, an antioxidant, is present with a high content, 248 mg/100g and chlorophyll which has an inhibitory effect on the dehydration of calcium oxalate with 0,185mg/g (1).

Overall, parsley has been shown to be effective in preventing urolithiasis (the process of stone formation in the urinary tract) (2).

In this study, the histopathological and biochemical results of oral administration of a parsley-rich diet demonstrated efficacy in reducing stress-induced gastric lesions by supporting the cellular antioxidant defense system (3).

Scientific evidence of the traditional use of parsley extract as an anti-diabetic agent and antioxidant in type 1 diabetes mellitus is confirmed in this other study (4).

Parsley studies

References__________________________________

(1) Optimization of extraction conditions of some polyphenolic compounds from parsley leaves (Petroselinum crispum).  Kuźma P, Drużyńska B, Obiedziński M.  Acta Sci Pol Technol Aliment. 2014 Apr-Jun;13(2):145-54.

(2) Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.
Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, Bishayee A.
Int J Mol Sci. 2018 Mar 7;19(3). pii: E765. doi: 10.3390/ijms19030765. Review.

(3) Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.  Akıncı A, Eşrefoğlu M, Taşlıdere E, Ateş B.  Balkan Med J. 2017 Jan;34(1):53-59. doi: 10.4274/balkanmedj.2015.1411.

(4) Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats.  Abou Khalil NS, Abou-Elhamd AS, Wasfy SI, El Mileegy IM, Hamed MY, Ageely HM.  J Diabetes Res. 2016;2016:8408326. doi: 10.1155/2016/8408326.