Guaiazulene (1,4-dimethyl-7-isopropylazulene), bicyclic sesquiterpene, occurs naturally in essential oils of many aromatic and medicinal plants, such as Chamomile (Matricaria Chamomilla) and blue intratropic Callis.
The name describes the structure of the molecule:
- Guaia- derives from "Guaiacum," a tropical tree from which guaiac oil is extracted. The term is often associated with compounds that have natural origins or are inspired by natural substances.
- -azulene refers to a class of organic compounds known as azulenes. Azulenes are known for their characteristic blue color and for their anti-inflammatory and soothing properties.
Description of Raw Materials Used in Production.
Guaiazulene is an organic compound primarily derived from guaiac oil, an essential oil extracted from the Guaiacum tree. It can also be sourced from chamomile (Matricaria chamomilla) and certain types of fungi.
Step-by-step Summary of Industrial Production Process.
- Extraction of guaiac oil from Guaiacum trees or blue chamomile.
- Isolation and purification of Guaiazulene from guaiac oil.
- Chemical synthesis of Guaiazulene through processes like hydrogenation, if derived from other sources.
- Further purification to ensure product purity.
- Quality control to confirm compliance with standards.
Form and Color.
Guaiazulene is a dark blue liquid.
Commercial applications:
Cosmetics Industry. Guaiazulene is used in cosmetic products for its soothing and anti-inflammatory properties, especially in products designed for sensitive or irritated skin.
Skin Care. Often found in creams, lotions, and post-shave products to reduce redness, irritation, and calm the skin.
Use in Medicine. Can be used in some ointments and topical preparations to treat mild inflammations and skin irritations.
Safety.
Generally considered safe for use in cosmetic and pharmaceutical products, but as with any ingredient, caution is advised in case of allergies or sensitivities.
Studies
It is an antioxidant, antifungal, antimicrobial, anti-inflammatory, anti-spasmodic, anti-ulcer, exerts anti-tumor activity and has relaxing properties (1).
Guaiazulene other studies
- Molecular Formula: C15H18
- Molecular Weight: 198.309 g/mol
- CAS: 489-84-9
- EC Number: 207-701-2
- UNIII: 2OZ1K9JKQC
- Beilstein Registry Number:1365001
- MDL number MFCD00003811
Synonyms:
- 1,4-Dimethyl-7-isopropylazulene
- 7-Isopropyl-1,4-dimethylazulene
- 1,4-Dimethyl-7-(1-methylethyl)azulene
- 1,4-dimethyl-7-(propan-2-yl)azulene
- Vetivazulen
- Purazulen
References______________________________________________________________________
(1) Higa T, Sakemi S. Guaiazulene derivatives and their methods of use. US Patent No. US 4755529 A. 1988:5–7.
Sleha R, Mosio P, Vydrzalova M, Jantovska A, Bostikova V, Mazurova J. In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014
Guaiazulene 
