Angelica Gigas Root Water
Media gradimento : 7
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Angelica Gigas Root Water è derivata dalle radici della pianta Angelica gigas (Apiaceae), comunemente conosciuta come angelica coreana o dong quai. Questo estratto acquoso cattura le proprietà benefiche delle radici ed è conosciuto per i suoi effetti idratanti, lenitivi e rivitalizzanti sulla pelle. Nelle formulazioni cosmetiche, l'acqua di radice di Angelica Gigas è apprezzata per la sua capacità di migliorare l'idratazione della pelle, migliorare la texture e fornire una sensazione rinfrescante.
Composizione Chimica e Struttura
Angelica Gigas Root Water contiene:
La composizione di Angelica Gigas Root Water consente di nutrire e idratare la pelle, fornendo al contempo le proprietà benefiche della pianta.
Proprietà Fisiche
Aspetto: Tipicamente un liquido chiaro o leggermente giallo.
Solubilità: Completamente solubile in acqua; solubilità limitata negli oli.
pH: Generalmente neutro o leggermente acido, garantendo compatibilità con varie formulazioni cosmetiche.
Odore: Profumo lieve ed erbaceo caratteristico dell'angelica.
Stabilità: Stabile in condizioni normali di conservazione; deve essere protetta da calore eccessivo e luce.
Processo di Produzione
Raccolta: Le radici della pianta Angelica gigas vengono raccolte durante la stagione appropriata per massimizzare la potenza.
Estrazione: Le radici subiscono un processo di estrazione in acqua, in cui vengono immerse o bollite per estrarre i composti benefici mantenendo le loro proprietà.
Purificazione: L'estratto acquoso risultante viene purificato per rimuovere impurità e garantire un prodotto di alta qualità.
Formulazione: L'acqua di radice di Angelica Gigas purificata viene incorporata in vari prodotti cosmetici per migliorarne le proprietà idratanti e lenitive.
Applicazioni
Cosmetica
Funzioni INCI:
Agente condizionante della pelle. Rappresenta il perno del trattamento topico della pelle in quanto ha la funzione di ripristinare, aumentare o migliorare la tolleranza cutanea a fattori esterni, compresa la tolleranza dei melanociti. La funzione più importante dell'agente condizionante è prevenire la disidratazione della pelle, ma il tema è piuttosto complesso e coinvolge emollienti ed umettanti che possono essere aggiunti nella formulazione.
Cura della Pelle: Comunemente presente in tonici, sieri e idratanti per i suoi effetti idratanti e lenitivi. Aiuta a migliorare la texture della pelle e fornisce una sensazione rinfrescante.
Cura dei Capelli: Utilizzata in prodotti per la cura dei capelli per idratare e nutrire il cuoio capelluto e i capelli, migliorando lucentezza e gestibilità.
Usi Industriali: Può essere impiegata in formulazioni che richiedono estratti acquosi naturali.
Considerazioni Ambientali e di Sicurezza
Generalmente considerato sicuro per l'applicazione topica, tuttavia, come tutti gli estratti, naturali o chimici, deve essere usato conformemente alle linee guida stabilite per evitare potenziali reazioni allergiche o irritazioni della pelle.
Le persone allergiche o con pelle molto sensibile dovrebbero prestare attenzione.
Pratiche di approvvigionamento e formulazione responsabili sono essenziali per garantire che l'ingrediente sia privo di contaminanti nocivi e prodotto in modo sostenibile.
Bibliografia__________________________________________________________________________
Song YR, Jang B, Lee SM, Bae SJ, Bak SB, Kim YW. Angelica gigas NAKAI and Its Active Compound, Decursin, Inhibit Cellular Injury as an Antioxidant by the Regulation of AMP-Activated Protein Kinase and YAP Signaling. Molecules. 2022 Mar 13;27(6):1858. doi: 10.3390/molecules27061858.
Abstract. Natural products and medicinal herbs have been used to treat various human diseases by regulating cellular functions and metabolic pathways. Angelica gigas NAKAI (AG) helps regulate pathological processes in some medical fields, including gastroenterology, gynecology, and neuropsychiatry. Although some papers have reported its diverse indications, the effects of AG against arachidonic acid (AA)+ iron and carbon tetrachloride (CCl4) have not been reported. In HepG2 cells, AA+ iron induced cellular apoptosis and mitochondrial damage, as assessed by mitochondrial membrane permeability (MMP) and the expression of apoptosis-related proteins. On the other hand, AG markedly inhibited these detrimental phenomena and reactive oxygen species (ROS) production induced by AA+ iron. AG activated the liver kinase B1 (LKB1)-dependent AMP-activated protein kinase (AMPK), which affected oxidative stress in the cells. Moreover, AG also regulated the expression of yes-associated protein (YAP) signaling as mediated by the AMPK pathways. In mice, an oral treatment of AG protected against liver toxicity induced by CCl4, as indicated by the plasma and histochemical parameters. Among the compounds in AG, decursin had antioxidant activity and affected the AMPK pathway. In conclusion, AG has antioxidant effects in vivo and in vitro, indicating that natural products such as AG could be potential candidate for the nutraceuticals to treat various disorders by regulating mitochondrial dysfunction and cellular metabolic pathways.
Sowndhararajan K, Kim S. Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review. Sci Pharm. 2017 Apr 28;85(2):21. doi: 10.3390/scipharm85020021.
Abstract. Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol (pyranocoumarin type components) have been reported to possess various pharmacological properties. Recently, several in vitro and in vivo studies have reported that the crude extracts and isolated components from the root of A. gigas exhibited neuroprotective and cognitive enhancement effects. Neuronal damage or death is the most important factor for many neurodegenerative diseases. In addition, recent studies have clearly demonstrated the possible mechanisms behind the neuroprotective action of extracts/compounds from the root of A. gigas. In the present review, we summarized the neuroprotective and cognitive enhancement effects of extracts and individual compounds from A. gigas root.
Lü J, Jiang C, Schell TD, Joshi M, Raman JD, Xing C. Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges. Am J Chin Med. 2022;50(6):1475-1527. doi: 10.1142/S0192415X2250063X.
Abstract. Angelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extract dietary supplements are marketed in the United States for memory health and pain management. We comprehensively reviewed the anticancer, analgesic, pro-memory and other bio-activities of AGN extract and its signature phytochemicals decursin, decursinol angelate, and decursinol a decade ago in 2012 and updated their anticancer activities in 2015. In the last decade, significant progress has been made for understanding the pharmacokinetics (PK) and metabolism of these compounds in animal models and single dose human PK studies have been published by us and others. In addition to increased knowledge of the known bioactivities, new bioactivities with potential novel health benefits have been reported in animal models of cerebral ischemia/stroke, anxiety, sleep disorder, epilepsy, inflammatory bowel disease, sepsis, metabolic disorders, osteoporosis, osteoarthritis, and even male infertility. Herein, we will update PK and metabolism of pyranocoumarins, review in vivo bioactivities from animal models and human studies, and critically appraise the relevant active compounds, the cellular and molecular pharmacodynamic targets, and pertinent mechanisms of action. Knowledge gaps include whether human pyranocoumarin PK metrics are AGN dose dependent and subjected to metabolic ceiling, or metabolic adaptation after repeated use. Critical clinical translation challenges include sourcing of AGN extracts, product consistency and quality control, and AGN dose optimization for different health conditions and disease indications. Future research directions are articulated to fill knowledge gaps and address these challenges.
Kweon B, Han YH, Kee JY, Mun JG, Jeon HD, Yoon DH, Choi BM, Hong SH. Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells. Molecules. 2020 Apr 27;25(9):2028. doi: 10.3390/molecules25092028. PMID: 32349276; PMCID: PMC7249139.
Abstract. Pancreatic cancer (PC) is one of the most severe cancers, and its incidence and mortality rates have steadily increased in the past decade. In this study, we demonstrate the effect of Angelica gigas Nakai extract on pancreatic ductal adenocarcinoma cells. We prepared A. gigas Nakai ethanol extract (AGE) using roots of A. gigas Nakai and detected its active compound decursin from AGE by ultra-performance liquid chromatography analysis. AGE and decursin significantly decreased viability and colony formation of PANC-1 and MIA PaCa-2 cells. AGE and decursin induced G0/G1 phase arrest through downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Caspase-3-dependent apoptosis of PANC-1 cells was promoted by AGE and decursin. Additionally, nontoxic concentrations of AGE and decursin treatment could suppress matrix metalloproteinase (MMP)-2 and MMP-9 expression and activity by inhibiting p38 phosphorylation. Taken together, this study demonstrates that AGE and decursin have potential properties to be considered in PC treatment.
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