Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application.
Jaiswal L, Shankar S, Rhim JW.
Carbohydr Polym. 2019 Nov 15;224:115191. doi: 10.1016/j.carbpol.2019.115191

Anti-Biofilm Activity of Grapefruit Seed Extract against Staphylococcus aureus and Escherichia coli.
Song YJ, Yu HH, Kim YJ, Lee NK, Paik HD.
J Microbiol Biotechnol. 2019 Aug 28;29(8):1177-1183. doi: 10.1041/jmb.1905.05022.

Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.
Chorin E, Hochstadt A, Granot Y, Khoury S, Schwartz AL, Margolis G, Barashi R, Viskin D, Ghantous E, Schnapper M, Mekori T, Fourey D, Guevara-Valdivia ME, Marquez MF, Zeltzer D, Rosso R, Viskin S.
Heart Rhythm. 2019 Aug;16(8):1141-1148. doi: 10.1016/j.hrthm.2019.04.039.

Bioactivity-guided isolation of potent anxiolytic compounds from leaves of Citrus paradisi.
Gupta V, Sharma R, Bansal P, Kaur G.
Ayu. 2018 Jan-Mar;39(1):21-28. doi: 10.4103/ayu.AYU_173_17.

Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors.
Yan W, Tao M, Jiang B, Yao M, Jun Y, Dai W, Tang Z, Gao Y, Zhang L, Chen X, Wang QL.
Cell Physiol Biochem. 2018;50(1):79-91. doi: 10.1159/000493960.

Preparation of antibacterial poly(lactide)/poly(butylene adipate-co-terephthalate) composite films incorporated with grapefruit seed extract.
Shankar S, Rhim JW.
Int J Biol Macromol. 2018 Dec;120(Pt A):846-852. doi: 10.1016/j.ijbiomac.2018.09.004.

Antimicrobial wrapping paper coated with a ternary blend of carbohydrates (alginate, carboxymethyl cellulose, carrageenan) and grapefruit seed extract.
Shankar S, Rhim JW.
Carbohydr Polym. 2018 Sep 15;196:92-101. doi: 10.1016/j.carbpol.2018.04.128.

Safety

Ciprofloxacin-induced Stevens-Johnson Syndrome with Grapefruit Juice Consumption: A Case Report.
Cravens MG, Sherman N, Sawaya J.
Cureus. 2019 Jan 4;11(1):e3827. doi: 10.7759/cureus.3827.

Grapefruit is harvested from the homonymous plant, the evergreen Citrus paradisi native to the Caribbean and then spread to many countries with a temperate climate.

The main producers are the United States (Florida), California and Israel.

White varieties: Marsh, Oroblanco, Duncan,  Golden, Wheeney, Melogold, Sweetie. 

Pink varieties: Marsh Pink, Ray Ruby, Redblush, Shambar, Foster, Henderson.

Red varieties: Star Ruby, Flame, Rio Red

It has a good content of citric acid, potassium, magnesium, vitamin C (1).

Grapefruit juice is one of the relatively low-calorie fruit juices, only 39 calories.

Grapefruit has a high content of polyphenols among which the class of flavonoids counts for 80% (1).  Grapefruit seed extract has demonstrated antibacterial efficacy in disinfecting denture surfaces and removing biofilms without causing deterioration on the surface of the resins (2).

Grapefruit studies

Contraindications: If grapefruit is taken in combination with certain drugs (statins, calcium blockers and others) it may cause allergies. Consult your doctor.

References_______________________________________________

(1) Grapefruit juice nutritional profile. Ivanova NN, Khomich LM, Perova IB, Eller KI.  Vopr Pitan. 2018;87(5):85-94. doi: 10.24411/0042-8833-2018-10057.

(2) Grapefruit seed extract effectively inhibits the Candida albicans biofilms development on polymethyl methacrylate denture-base resin.  Tsutsumi-Arai C, Takakusaki K, Arai Y, Terada-Ito C, Takebe Y, Imamura T, Ide S, Tatehara S, Tokuyama-Toda R, Wakabayashi N, Satomura K.  PLoS One. 2019 May 28;14(5):e0217496. doi: 10.1371/journal.pone.0217496.