Compendium of the most significant studies with reference to properties, intake, effects.

Angulo B, Fraile JM, Gil L, Herrerías CI. Comparison of Chemical and Enzymatic Methods for the Transesterification of Waste Fish Oil Fatty Ethyl Esters with Different Alcohols. ACS Omega. 2020 Jan 17;5(3):1479-1487. doi: 10.1021/acsomega.9b03147. PMID: 32010821;

Abstract. Fatty acid esters of 2-ethyl-1-hexanol (EH), 2-hexyl-1-decanol (HD), and isopropanol have been obtained from a mixture of ethyl esters obtained as a fish oil byproduct. Homogeneous base catalysis with alkaline hydroxides and alkoxides has been compared with the use of two commercially available immobilized lipases.

Tan DC, Kassim NK, Ismail IS, Hamid M, Ahamad Bustamam MS. Identification of Antidiabetic Metabolites from Paederia foetida L. Twigs by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Study. Biomed Res Int. 2019 May 29;2019:7603125. doi: 10.1155/2019/7603125.  

Abstract. This study is to evaluate the enzymatic inhibition activity of Paederia foetida twigs extracts and to identify the metabolites responsible for the bioactivity by gas chromatography-mass spectrometry (GC-MS) metabolomics profiling.  

Li ZQ, Zhang S, Luo JY, Wang SB, Dong SL, Cui JJ. Odorant-binding proteins display high affinities for behavioral attractants and repellents in the natural predator Chrysopa pallens. Comp Biochem Physiol A Mol Integr Physiol. 2015 Jul;185:51-7. doi: 10.1016/j.cbpa.2015.03.011.

Abstract.  In this study, we cloned five odorant-binding protein (OBP) genes from C. pallens (CpalOBPs).

Li ZQ, Zhang S, Cai XM, Luo JY, Dong SL, Cui JJ, Chen ZM. Three odorant binding proteins may regulate the behavioural response of Chrysopa pallens to plant volatiles and the aphid alarm pheromone (E)-β-farnesene. Insect Mol Biol. 2017 Jun;26(3):255-265. doi: 10.1111/imb.12295.

Abstract. Understanding the functions of C. pallens odorant-binding proteins (CpalOBPs) and behavioural responses of C. pallens to plant volatiles and aphid alarm pheromone (E)-ß-farnesene has important implications for population establishment after lacewing release.

Arrese-Igor S, Alegría A, Colmenero J. On the non-exponentiality of the dielectric Debye-like relaxation of monoalcohols. J Chem Phys. 2017 Mar 21;146(11):114502. doi: 10.1063/1.4978585.

Abstract. We have investigated the Debye-like relaxation in a series of monoalcohols (MAs) by broadband dielectric spectroscopy and thermally stimulated depolarization current techniques in order to get further insight on the time dispersion of this intriguing relaxation.

Hexyldecanol: : properties, uses, pros, cons, safety

Hexyldecanol is a chemical compound, aliphatic alcohol.

The name defines the structure of the molecule

• "Hexyl". Indicates the presence of a hexyl side chain, which is an alkyl group.
• "Decanol". Is a fatty alcohol with a chain of 10 carbon atoms.

Description of the raw materials used in its production.

• Fatty Aldehyde - For example, decanal, an aldehyde with a 10-carbon chain.
• Fatty Alcohol - For example, hexan-1-ol, an alcohol with a 6-carbon chain.
• Catalyst - For example, potassium hydroxide or sulfuric acid, used to catalyze the reaction.

Step-by-step summary of its industrial chemical synthesis process. 

• Preparation of Reagents - Decanal and hexan-1-ol are prepared or purchased as raw materials.
• Chain Extension Reaction - The fatty aldehyde (decanal) reacts with the fatty alcohol (hexan-1-ol) in the presence of a catalyst. This extends the carbon chain of the aldehyde.
• Reduction - The product formed in step 2 is reduced to an alcohol, which in this case is Hexyldecanol.
• Purification - The product is purified to remove impurities and unreacted reagents, e.g., by distillation.

It occurs as a red/amber liquid.

What it is used for and where

Raw material for the production of surfactants, perfumes, herbicides, plasticisers, synthetic fibres, defoamers, lubricant additives, etc.. 

Food

• Used in small quantities in the preparation of various fruit, cream, coconut etc. flavours.
• Ripening agent for green fruits 

Cosmetics

Dispersant and, in small amounts, incorporated into fragrances in scented soaps and as a mixing agent for linalool.

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Skin conditioning agent - Emollient. Emollients have the characteristic of enhancing the skin barrier through a source of exogenous lipids that adhere to the skin, improving barrier properties by filling gaps in intercorneocyte clusters to improve hydration while protecting against inflammation. In practice, they have the ability to create a barrier that prevents transepidermal water loss.  Emollients are described as degreasing or refreshing additives that improve the lipid content of the upper layers of the skin by preventing degreasing and drying of the skin. The problem with emollients is that many have a strong lipophilic character and are identified as occlusive ingredients; they are oily and fatty materials that remain on the skin surface and reduce transepidermal water loss. In cosmetics, emollients and moisturisers are often considered synonymous with humectants and occlusives.

Printing Industry

• Solvent for inks

Industry 

• Industrial deodorisation. To cover bad odours of industrial products.

PVC

•  Raw material for PVC yarn coating materials and plasticisers

Other applications

• Solvent and stabiliser for synthetic raw materials, pesticides, herbicides.
• Oil drilling and in secondary oil recovery.

Safety

Chemical compound generally considered safe for human health. Sporadphic episodes of specific allergy may occur, as with any chemical compound.

Hexyldecanol studies

Typical optimal commercial product characteristics 2-hexyldecan-1-ol

• Molecular Formula  C₁₆H₃₄O    C₁₀H₂₂O
• Linear Formula     CH₃(CH₂)₇CH[(CH₂)₅CH₃]CH₂OH
• Molecular Weight     242.44
• Exact Mass   242.260971
• CAS  2425-77-6     112-30-1
• UNII     151Z7P1317
• EC Number   219-370-1    203-956-9
• DSSTox Substance ID  DTXSID1041265
• IUPAC  2-hexyldecan-1-ol
• InChI=1S/C16H34O/c1-3-5-7-9-10-12-14-16(15-17)13-11-8-6-4-2/h16-17H,3-15H2,1-2H3 
• InChl Key      XULHFMYCBKQGEE-UHFFFAOYSA-N
• SMILES   CCCCCCCCC(CCCCCC)CO
• MDL number  MFCD00060903
• PubChem Substance ID    24870185
• ChEBI  183266
• NSC   2399

Synonyms:

• 2-Hexyl-1-decanol
• 1-Decanol, 2-hexyl-
• 2-Hexyldecanol

References__________________________________________________________________________

Bährle-Rapp, M. (2007). Hexyldecanol. In Springer Lexikon Kosmetik und Körperpflege (pp. 256-256). Berlin, Heidelberg: Springer Berlin Heidelberg.

Hakozaki, T., Laughlin, T., Zhao, S., Wang, J., Deng, D., Jewell‐Motz, E., & Elstun, L. (2013). A regulator of ubiquitin–proteasome activity, 2‐hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots. British Journal of Dermatology, 169, 39-44.

Abstract. Background. 2-Hexyldecanol has long been used in skin-care products, but has not previously been reported as an active ingredient for skin benefits. Objectives. To evaluate 2-hexyldecanol in in vitro and ex vivo systems and, if found to be active, progress it to topical clinical testing to determine effects on pigmentation in skin. Methods. 2-Hexyldecanol was tested in melanocyte cell culture systems (B16 mouse melanoma cells and normal human melanocytes) for its effect on proteolytic activity and melanin production, in the absence and presence of the proteasome-specific inhibitor, MG132. It was further tested in a human skin explant model for its effect on melanin production. Lastly, topically applied 2-hexyldecanol was evaluated for its effect on the appearance of facial pigmentation in an 8-week, randomized, double-blind, vehicle-controlled, split-face incomplete block design study in Chinese women. Results. In submerged cell culture, 2-hexyldecanol upregulated proteolytic activity and decreased melanin synthesis. These effects were antagonized by the proteasome-specific inhibitor MG132. MG132, tested in the absence of 2-hexyldecanol, increased melanin production. In a human skin explant model, topical 2-hexyldecanol suppressed the production of melanin vs. a vehicle control. In a human clinical study in Chinese women (n = 110 observations per test material), a 2-hexyldecanol-containing formulation significantly reduced the appearance of facial hyperpigmented spots vs. its control. Conclusions. These data indicate that regulation of proteasome activity is a viable target for control of melanin production, that 2-hexyldecanol upregulates proteasomal activity in melanocytes, and that topical 2-hexyldecanol reduces the appearance of hyperpigmentation.