E100 Curcumin - Descrizione

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2023-Dec-28 16:33

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Curcumin is a yellow-orange polyphenolic flavonoid and is the main constituent of the rhizome of the spice turmeric (Curcuma longa L. family Zingiberaceae).

It is used as a spice in the kitchen especially in India.

Used in medicine as an anti-inflammatory.

Labeled as E100 in the list of food additives as dye.

There is a lot of positive scientific literature on Curcumin. It has anti-inflammatory effects that retard liver fibrosis and cirrhosis at the indicated doses (experiments on laboratory animals) (1) and in vivo (2).

Curcumin has known and explicit biological antitumor properties. It exerts an anti-proliferative and pro-apoptotic effect in tumor cells (3).

In healthy middle-aged and elderly adults, 12 weeks of curcumin supplementation (2000 mg / day Longvida®; n = 20) improved the endothelial function of the artery by increasing the vascular bioavailability of nitric oxide and reduced oxidative stress (4 ).

Curcumin exercises neuroprotective actions, in a model of cerebral ischemia, which are probably related to its anti-inflammatory activity (5).

It also protects against the neurotoxicity of aluminium (6).

Safety

Be careful not to exceed the doses recommended by your doctor.

Molecular formula: C₂₁H₂₀O₆

Molecular weight: 368.38

CAS: 458-37-7

References_____________________________________________________________________

(1) Fu, Y.; Zheng, S.; Lin, J.; Ryerse, J.; Chen, A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol. Pharmacol. 2008

(2) Ameliorative Effect of Curcumin-Encapsulated Hyaluronic Acid-PLA Nanoparticles on Thioacetamide-Induced Murine Hepatic Fibrosis.
Chen YN, Hsu SL, Liao MY, Liu YT, Lai CH, Chen JF, Nguyen MT, Su YH, Chen ST, Wu LC. - Int J Environ Res Public Health. 2016 Dec

(3) Curcumin Inhibits Gastric Carcinoma Cell Growth and Induces Apoptosis by Suppressing the Wnt/β-Catenin Signaling Pathway.
Zheng R, Deng Q, Liu Y, Zhao P.
Med Sci Monit. 2017 Jan

Zhang N, Gao M, Wang Z, Zhang J, Cui W, Li J, Zhu X, Zhang H, Yang DH, Xu X. Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level. J Pharm Biomed Anal. 2021 May 7;201:114129. doi: 10.1016/j.jpba.2021.114129.

(4) Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.
Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR.
Aging (Albany NY). 2017 Jan

(5) Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.
de Alcântara GF, Simões-Neto E, da Cruz GM, Nobre ME, Neves KR, de Andrade GM, Brito GA, Viana GS.
J Tradit Complement Med. 2016 Feb

(6) Efficacy of Curcumin in Ameliorating Aluminum- Induced Neurotoxicity.
Zhang H, Zhao W, Malhotra A.
J Environ Pathol Toxicol Oncol. 2018;37(2):163-172. doi: 10.1615/JEnvironPatholToxicolOncol.2018026437.

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