Carboxymethyl starch sodium
Sodium carboxymethyl starch / sodium starch glycolate – (carboxymethylated starch polymer, sodium salt)

Synonyms: sodium carboxymethyl starch, sodium starch glycolate, carboxymethyl starch sodium salt, Explotab, Primojel
INCI / functions: binder, emulsion stabilizer, film former, viscosity controlling (thickener/consistency regulator)

Definition

An anionic derivative of starch (a plant polysaccharide), obtained by introducing carboxymethyl groups onto the glucidic backbone and neutralizing them as a sodium salt. Structurally, it is mainly composed of a starch polymer (glucose units linked in polysaccharide chains) bearing carboxymethyl substituents and associated sodium counter-ions. In water it tends to hydrate and swell rapidly, increasing viscosity and supporting the physical stability of dispersions and emulsions. In the pharmaceutical field it is widely used as a superdisintegrant (promotes rapid disintegration of tablets/capsules). In cosmetics it is used as a thickener/consistency regulator, binder, and stability aid in rinse-off products and in appropriately balanced aqueous or hydroalcoholic systems.

Calories (energy value)

Identification data and specifications

Functional role and clarification “thickener / stabilizer / superdisintegrant”

Formulation compatibility

Use guidelines (indicative)

Typical applications

Cosmetics

Binder agent. Ingredient that is used in cosmetic, food and pharmaceutical products as an anti-caking agent with the function of making the product in which it is incorporated silky, compact and homogenous. The binder, either natural such as mucilage, gums and starches or chemical, may be in the form of a powder or liquid.

Emulsion stabiliser. Emulsions are thermodynamically unstable. Emulsion stabilisers improve the formation and stability of single and double emulsions. as well as their shelf-life. It should be noted that in the structure-function relationship, the molar mass of the ingredient used plays an important role.

Film-forming agent. It produces, upon application, a very thin continuous film with an optimal balance of cohesion, adhesion and stickiness on skin, hair or nails to counteract or limit damage from external phenomena such as chemicals, UV rays and pollution.

Viscosity control agent. It controls and adapts, Increasing or decreasing, viscosity to the required level for optimal chemical and physical stability of the product and dosage in gels, suspensions, emulsions, solutions. 

• Cleansers and cleansing: viscosity adjustment and support to stability of surfactant systems.

• O/W emulsions and lotions: rheology aid and stabilizer.

• Film-forming products: contribution to film formation and sensory profile (in synergy with other polymers).

• Pharmaceutical: superdisintegrant for rapid disintegration and release in solid dosage forms.

Quality, grades and specifications

Safety, regulation and environment

Formulation troubleshooting

Conclusion

Carboxymethyl starch sodium is a modified polysaccharide with strong formulation utility: in cosmetics it mainly provides viscosity control, binding, and stability support; in pharmaceuticals it is a benchmark superdisintegrant. Performance depends materially on grade/quality, particle profile, electrolytes, and hydration conditions: a robust dispersion strategy and rheology checks after rest are the key levers to achieve repeatable results.

Studies

 Resists amylase in vitro In the small intestine it is not hydrolyzed by D-glucose in the small intestine, but can be fermented in the colon by anaerobic bacteria (1).

Electrolyte soluble in cold water. Insoluble in ethanol, ether, chloroform and other organic solvents. In aqueous solution above 80°C there is a decrease in viscosity.

It is most commonly called in its abbreviated form CMS-Na. 

Carboxymethyl starch ether was first produced in 1924 and as an industrial product in 1940.

Commercially it is a modified starch that is produced in two types: carboxymethyl starch (CMS) and pregelatinized starch. Depending on the raw materials used for preparation, it is marketed as pregelatinized corn starch and pregelatinized tapioca/cassava starch.

Sodium carboxymethyl starch studies

What it is used for

• Detergents and cleaners.  It has the ability to improve suspension dispersion and prevents dirt particles or pollutants from entering the suspension.
• Construction. Stucco powder, waterproof wall stucco, cement plastering mortar, cement insulation cracking mortar, tile adhesives, drywall. In cement and gypsum processing, it is used with hydroxypropylmethylcellulose as a thickener, resists cracking, improves the workability of raw materials, and can reduce the content of hydroxypropylmethylcellulose.
• Paper. Has the function of sizing, coagulating to improve tear strength.
• Textile. Finishing agent, sizing agent.
• Petroleum. Has good rheological properties that improve stability, water retention, flow and liquid loss.
• Paints. Anti-suspension agent, emulsifying dispersant, filmogen, thickener and binder.
• Feed. Embedded in formula with carboxymethylcellulose and sodium alginate offers good compatibility with Xanthan gum.
• Pharmaceutical. It functions as a superdisintegrator for all solid oral dosage forms. It has an ability to swell up to 280 - 320 times its original granule volume. It is an excipient especially used for wet or dry granulation and direct compression and can be incorporated in intra- or extra-granular mode. or both. It generally has a potato starch base. It is produced in two types: Type A with low viscosity and low residual solvent and Type B particularly suitable in strongly acidic drug formulations to maintain stability and resist acidic pH.
• PVA. In some sectors it is a good substitute for polyvinyl alcohol.
• Medicine. Sodium carboxymethyl starch (CMS-Na), is a type of food additive with high degree of substitution and is also known as a prebiotic. This study finds that it can be used as an adjuvant in constipation (2).

Where to buy

• Molecular Formula: [C₆H₇O₂(OH)₂OCH₂COONa]n     [C₁₀H₁₉O₈Na]n
• Linear Formula  (C₂H₄O₃)x · (Na)x
• PMolecular Weight:     290.243
• Exact Mass   290.097748
• CAS: 9063-38-1
• UNII 5856J3G2A2
• EC Number: 1308068-626-2
• DSSTox Substance ID: 
• MDL number  MFCD00217761
• PubChem Substance ID 
• InChI Key    MOSFIJXAXDLOML-UHFFFAOYSA-N
• SMILES    
• IUPAC 
• ChEBI    

Synonyms: 

• CMS-Na
• Carboxymethyl starch sodium
•  Sodium starch glycolate
• Sodium starch glycolate type B
• Sodium carboxyl methylstarch
• Sodium [(3R,4S,5R)-4,5-dihydroxy-6-methoxy-3-methyltetrahydro-2H-pyran-2-yl]methanolate - hydroxyacetic acid (1:1:1)

References______________________________________________________________

(1) Edwards CA, Xie C, Garcia AL. Dietary fibre and health in children and adolescents. Proc Nutr Soc. 2015 Aug;74(3):292-302. doi: 10.1017/S0029665115002335. 

Abstract. The role of dietary fibre in promoting sustained health has been studied for several decades and in adults there is good evidence that diets rich in high-fibre foods reduce the risk of chronic diseases, including CVD and cancer. Research in this area, however, has been hampered by uncertainties about the definition of dietary fibre which has resulted in many studies measuring fibre in different ways. There is also a wide range of properties and actions of different fibres in the human body, depending on their solubility, viscosity and fermentability by the colonic microbiota. This review considers the epidemiological evidence for dietary fibre and health in children and the current dietary recommendations and measured intakes in several countries using national surveys. In children and adolescents, there is a particular lack of relevant research on which to formulate appropriate dietary fibre recommendations and these are often based on extrapolation from adult data. However, children are not little adults and have differing physiology and nutritional needs as they grow. The dietary recommendations in different countries are based on varying premises and daily amounts. Intakes vary from country to country and on the whole do not meet recommendations. Much more research is needed in children to fully understand the impact of dietary fibre on growth and health in the young to allow more appropriate recommendations to be made.

(2) Lu WD, Wu ML, Zhang JX, Huang TT, Du SS, Cao YX. The effect of sodium carboxymethyl starch with high degree of substitution on defecation. PLoS One. 2021 Sep 3;16(9):e0257012. doi: 10.1371/journal.pone.0257012. 

Abstract. Sodium carboxymethyl starch (CMS-Na), a kind of food additive with high degree of substitution, is also known as a prebiotic. The aim of this study was to determine the effect of CMS-Na on defecation. Constipated mouse model was prepared by loperamide. Normal rats were also used in the study. Short-chain fatty acids in rat feces were detected by gas chromatography. The bacterial communities in rat feces were identified by 16S rDNA gene sequencing. 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase 1 (Tph1) were measured by ELISA. The results showed that CMS-Na increased the fecal granule counts and intestinal propulsion rate in constipated mice. The contents of water, acetic acid, propionic acid and n-butyrate in feces, Tph1 in colon and 5-HT in serum of rats were increased. In addition, CMS-Na shortened the colonic transport time in rats. The 16S rDNA gene sequencing results indicated that CMS-Na increased the relative abundance of Alloprevotella and decreased the proportion of Lactobacillus. However, the biodiversity of the normal intestinal flora was not altered. In conclusion, CMS-Na can promote defecation in constipated mice. The mechanism may be related to the regulation of Alloprevotella and Lactobacillus in colon, the increase of short-chain fatty acids, and the promotion of the synthesis of Tph1 and 5-HT.

Lemieux M, Gosselin P, Mateescu MA. Carboxymethyl starch mucoadhesive microspheres as gastroretentive dosage form. Int J Pharm. 2015 Dec 30;496(2):497-508. doi: 10.1016/j.ijpharm.2015.10.027.