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 | "Descrizione" di Al222 (24092 pt) | 27-gen-2026 09:31 |
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Opaspray M-1-711 1B: properties, uses, pros, cons, safety, alternatives
Opaspray M-1-711 1B is a chemical compound used in the film coating of tablets as a colouring agent. Various other chemical compounds are found in its composition: Water, Titanium Dioxide, Hydroxypropyl Methylcellulose are generally always present. An alcohol is also included, which may be methylated ethyl alcohol or SDA Specially Denatured Alcohol CAS 64-17-5, as well as a colouring lacquer.
The name describes the structure of the molecule
- "Opaspray" i is typically a trade name indicating a coating or colorant used in the pharmaceutical industry, especially for tablet coatings.
- "M-1-711 1B" refers to a specific formula or variant of the Opaspray product
Description of raw materials used in production
- Water. Serves as a solvent or vehicle in many coating formulations.
- Titanium Dioxide. A white pigment used to provide opacity and color to the coating.
- Hydroxypropyl Methylcellulose (HPMC). A water-soluble polymer used as a film-former in the coating.
- Methylated ethyl alcohol. A volatile solvent used to aid in the dispersion of ingredients and in evaporation during the drying process.
The procedure of application on tablets takes place in several stages:
- Selection of ingredients. The first step in the preparation of a coating is the selection of ingredients. This includes a polymer (which forms the film), a plasticizer (which helps the film to remain flexible), a pigment (which provides the color) and other additives if necessary.
- Preparation. The ingredients are mixed to form a coating solution that leads to the dissolution of the polymer and other ingredients in a suitable solvent to form a homogeneous solution.
- Application of the coating. The coating solution is then applied to the tablets or other dosage forms using a fluidized coating medium. The coating solution is sprayed onto the tablets as they are produced and the solvent is then evaporated to leave a thin film of the coating.
- Drying and curing. After application of the coating, the tablets are dried. Curing involves heating the tablets to a specific temperature for a certain period of time to ensure that the coating is fully adapted.
- Quality control. The final product is tested to ensure it meets the required specifications. This may involve testing for parameters such as coating thickness, color and gloss.
Alternatives
| Option | Product type | Key advantages |
|---|---|---|
| Opadry® TF (TiO₂-free) | Ready-to-use film coating system without titanium dioxide | The simplest “drop-in” commercial route to qualify; available with different polymers/opacifiers, with a good balance of performance and processability. |
| VIVACOAT® free (TiO₂-free) | Ready-to-use HPMC-based system, TiO₂-free | Eco-positioned (ready-to-use, water-based) and free from TiO₂; useful when you want a pre-formulated solution with clear specifications. |
| HPMC + calcium carbonate opacifier | Custom TiO₂-free coating | Calcium carbonate is one of the most used opacity substitutes; often more eco-friendly and widely available, though achieving the same whiteness may require higher weight gain. |
| PVA-based TiO₂-free (with mineral opacifier) | Alternative film former system (TiO₂-free) | Good film robustness and uniform finish; optimized systems exist to improve opacity/whiteness without TiO₂. |
| TiO₂-free starch-based systems (e.g., rice starch) | Coating with bio-based opacifier | Strong “natural/bio-based” positioning; useful when the goal is lowering overall footprint (always validate processability and aesthetic outcome). |
Opaspray is responsible for the significant change in the thermomechanical behaviour of hydroxypropyl methylcellulose (1).
For more information: Opaspray studies
References_________________________________________________________________________
(1) Masilungan, F. C., & Lordi, N. G. (1984). Evaluation of film coating compositions by thermomechanical analysis. I. Penetration mode. International journal of pharmaceutics, 20(3), 295-305.
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