"Descrizione" by daybreak88 (271 pt) | 2024-Oct-02 21:30 |
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Il lattato di zinco è un composto composto chimico formato dal sale di acido lattico e zinco.
Il nome definisce la struttura della molecola:
Descrizione delle materie prime utilizzate nella sua produzione:
Il processo di sintesi avviene in diverse fasi.
Si presenta in forma di polvere bianca.
A cosa serve e dove si usa
Cosmetica
E' un ingrediente soggetto a restrizioni III/24 come Voce pertinente negli allegati del regolamento europeo sui cosmetici n. 1223/2009. Regolamentato dalla direttiva 82/368/CEE. Concentrazione massima nella preparazione pronta all'uso 1% (come zinco). Precauzioni: Water-soluble zinc salts with the exception of zinc 4- hydroxy-benzenesulphonate (entry 25) and zinc pyrithione (Annex II, entry 1670)
Alimentazione
Il lattato di zinco è spesso utilizzato come integratore alimentare e additivo alimentare. Serve come fonte di zinco, un minerale necessario che supporta varie funzioni biologiche, tra cui la funzione immunitaria, la sintesi proteica, la sintesi del DNA e la divisione cellulare. Viene anche utilizzato come esaltatore di sapidità in alcuni alimenti.
Medicina
Il lattato di zinco è utilizzato in alcuni prodotti medicinali per le sue capacità di cicatrizzare le ferite. Può contribuire alla guarigione di tagli minori, ustioni e altre irritazioni della pelle.
Alimentazione animale.
Si usa anche come integratore di zinco nei mangimi per animali, per fornire al bestiame la quantità necessaria di questo minerale essenziale.
Studi
Lo zinco è un oligoelemento essenziale per tutti gli organismi eucarioti. È richiesto per l'attività catalitica o l'integrità strutturale di oltre 300 enzimi (1).
Il lattato di zinco è un sale dell'acido lattico, che è un importante prodotto fermentativo dei batteri dell'acido lattico. I lattati sono usati come conservanti alimentari. Diversi meccanismi sono responsabili delle proprietà antimicrobiche dell'acido lattico e dei suoi sali (2).
Il lattato di zinco è stato usato per ridurre alcune infezioni del tratto respiratorio (3).
Lattato di zinco e alluminio, zinco e cloruro di alluminio (0,1%), hanno lavorato in sinergia con 100 UI di nisina per ml per controllare la crescita di L. monocytogenes (4).
Il lattato di zinco viene usato nei dentifrici come antibatterico (5).
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Sinonimi :
Bibliografia_____________________________________________________________________
(1) Berg JM, Shi Y The galvanization of biology: a growing appreciation for the roles of zinc. Science. 1996 Feb 23; 271(5252):1081-5.
Abstract. Zinc ions are key structural components of a large number of proteins. The binding of zinc stabilizes the folded conformations of domains so that they may facilitate interactions between the proteins and other macromolecules such as DNA. The modular nature of some of these zinc-containing proteins has allowed the rational design of site-specific DNA binding proteins. The ability of zinc to be bound specifically within a range of tetrahedral sites appears to be responsible for the evolution of the side range of zinc-stabilized structural domains now known to exist. The lack of redox activity for the zinc ion and its binding and exchange kinetics also may be important in the use of zinc for specific functional roles.
(2) Turovskiy Y, Chikindas ML. Zinc Lactate and Sapindin Act Synergistically with Lactocin 160 Against Gardnerella vaginalis. Probiotics Antimicrob Proteins. 2011 Jun 1;3(2):144-9. doi: 10.1007/s12602-011-9068-5
Abstract. Lactocin 160 is a vaginal probiotic-derived bacteriocin shown to selectively inhibit the growth of Gardenerella vaginalis and some other pathogens commonly associated with bacterial vaginosis. The natural origin of this peptide, its safety, and selective antimicrobial properties make it a promising candidate for successful treatment and prophylaxis of bacterial vaginosis (BV). This study evaluated interactions between lactocin 160 and four other natural antimicrobials in the ability to inhibit G. vaginalis. We report that zinc lactate and soapnut extract act synergistically with lactocin 160 against this pathogen and therefore have a potential to be successfully used as the components of the multiple-hurdle antimicrobial formulation for the treatment of BV.
(3) Suara RO, Crowe JE Jr. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother. 2004 Mar;48(3):783-90.
Abstract. Zinc supplementation decreases the morbidity of lower respiratory tract infection in pediatric patients in the developing world. We sought to determine if zinc mediates a specific inhibitory effect against the major cause of pediatric lower respiratory tract disease, respiratory syncytial virus (RSV). We determined the in vitro inhibitory effect of three zinc salts (zinc acetate, lactate, and sulfate) on the replication of RSV at various concentrations of 10 and 1 mM and 100 and 10 microM. The degree of inhibition of RSV replication was examined in the presence of zinc during preincubation, adsorption, or penetration and was compared with that caused by salts of other divalent cations. Complete inhibition of RSV plaque formation was observed at 1 and 10 mM, representing reductions that were >or=10(6)-fold. At the lowest concentration tested, 10 microM, we observed >or=1000-fold reductions in RSV yield when zinc was present during preincubation, adsorption, penetration, or egress of virus. The therapeutic indices, determined as ratios of 50% toxicity concentration to 50% inhibitory concentration, were 100, 150, and 120 for zinc acetate, zinc lactate, and zinc sulfate, respectively. The inhibitory effect of zinc salts on RSV was concentration dependent and was not observed with other salts containing divalent cations such as calcium, magnesium, and manganese. RSV plaque formation was prevented by pretreatment of HEp-2 cell monolayer cultures with zinc or by addition of zinc to methylcellulose overlay media after infection. The results of this study suggest that zinc mediates antiviral activity on RSV by altering the ability of the cell to support RSV replication.
(4) McEntire JC, Montville TJ, Chikindas ML. Synergy between nisin and select lactates against Listeria monocytogenes is due to the metal cations. J Food Prot. 2003 Sep;66(9):1631-6.
Abstract. Listeria monocytogenes, a major foodborne pathogen, has been responsible for many outbreaks and recalls. Organic acids and antimicrobial peptides (bacteriocins) such as nisin are produced by lactic acid bacteria and are commercially used to control pathogens in some foods. This study examined the effects of lactic acid (LA) and its salts in combination with a commercial nisin preparation on the growth of L. monocytogenes Scott A and its nisin-resistant mutant. Because of an increase in its activity at a lower pH, nisin was more active against L. monocytogenes when used in combination with LA. Most of the salts of LA, including potassium lactate, at up to 5% partially inhibited the growth of L. monocytogenes and had no synergy with nisin. Zinc and aluminum lactate, as well as zinc and aluminum chloride (0.1%), worked synergistically with 100 IU of nisin per ml to control the growth of L. monocytogenes Scott A. No synergy was observed when zinc or aluminum lactate was used with nisin against nisin-resistant L. monocytogenes. The nisin-resistant strain was more sensitive to Zn lactate than was wild-type L. monocytogenes Scott A; however, the cellular ATP levels of the nisin-resistant strain were not significantly affected. Changes in the intracellular ATP levels of the wild-type strain support our hypothesis that pretreatment with zinc lactate sensitizes cells to nisin. The similar effects of thesalts of hydrochloric and lactic acids support the hypothesis that metal cations are responsible for synergy with nisin.
(5) Ledder RG, McBain AJ. An in vitro comparison of dentifrice formulations in three distinct oral microbiotas. Arch Oral Biol. 2012 Feb;57(2):139-47. doi: 10.1016/j.archoralbio.2011.08.004. Epub 2011 Sep 7.
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