Magnesium nitrate studies

The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries. The rats were injected with one of examined magnesium preparations (5 mg/1 kg body weight) 1 h prior to or 1-2 sec after occlusion. The control group rats were treated with physiological saline at the same terms. Irrespective of the moment of injection, magnesium nitrate demonstrated significant protective effect on dynamics of neurological disorders and mortality, while similar effects of magnesium sulfate and magnesium chloride were insignificant (1).

The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension at the age of 12-13 weeks were allocated to two groups according to their arterial blood pressure. Rats from the control group received purified water, while the experimental animals from the second group received magnesium nitrate dissolved in purified water at a dose of 50 mg/kg. After four weeks of treatment, blood pressure was measured, the anatomical and functional parameters of the heart were recorded using an ultrasonograph, vascular reactivity was assayed in organ bath experiments and the cardioprotective effects of magnesium nitrate administration was assayed in an ex vivo experimental heart infarction model. Treatment with magnesium nitrate significantly increased the nitrate concentration in the plasma (from 62 ± 8 μmol/l to 111 ± 8 μmol/L), and attenuated the increase in the arterial blood pressure. In the control and magnesium nitrate groups, the blood pressure rose by 21 ± 3 mmHg and 6 ± 4 mmHg, respectively. The administration of magnesium nitrate had no effect on the altered vasoreactivity, heart function or the size of the heart infarction. In conclusion, our results demonstrate that magnesium nitrate effectively attenuates the rise in arterial blood pressure. However, a longer period of administration or earlier onset of treatment might be needed to delay the development of complications due to hypertension (2).

Magnesium nitrate is used in animal feed and in agriculture (3). 

References______________________________________________________________________

(1) Kuzenkov VS, Krushinskii AL. Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats.   Bull Exp Biol Med. 2014 Oct;157(6):721-3. doi: 10.1007/s10517-014-2651-5. Epub 2014 Oct 24.

(2) Vilskersts R, Kuka J, Liepinsh E, Cirule H, Gulbe A, Kalvinsh I, Dambrova M.  Magnesium nitrate attenuates blood pressure rise in SHR rats.   Magnes Res. 2014 Jan-Mar;27(1):16-24. doi: 10.1684/mrh.2014.0358.

(3) Sowande, O. S., & Aina, A. B. J. (2001). Magnesium nitrate as dietary additive in the nutrition of West African Dwarf goat. Archivos de zootecnia, 50(191), 335-341.

Abstract. Twelve female West African Dwarf (WAD)goats were used in an 8 weeks feeding trial toinvestigate magnesium nitrate as a dietary additivein goats’ nutrition. Four treatment levels (0, 0.5,1.0and 1.5 p.100) of magnesium nitrate were used toobtain four diets containing 0.21, 0.32, 0.45 and0.65 p.100 magnesium. Results indicated thatanimals on diet 4, though consumed the lowestdry matter (0.282 kgDM/day), promoted the bestaverage daily gain (39.00 g/d), feed conversionratio (8.28), serum magnesium (3.10 mg/100ml)and magnesium retention (0.160 g/kgBW). Theperformance and magnesium retention of goatson other diets were significantly lower. Magnesiumnitrate can therefore, be used up to 1.5 p.100 0f diets to increase magnesium intake, without anyadverse effect, for a better performance in WAD goats.

Chakraborty, P., & Bose, B. (2020). Effects of magnesium nitrate and boric acid on germination and seedling growth parameters of wheat (Triticum aestivum L.) var. HUW-468. Journal of Pharmacognosy and Phytochemistry, 9(4), 804-808.

Abstract. Plant requires both macro and micronutrients for regulating their metabolic process throughout different phases of growth and development. Magnesium and Boron as a part of macro and micronutrient respectively perform specific function inside plant body. Here, to find out the effect of these two nutrients as seed priming agent, an experiment was conducted. In the present piece of experiment wheat seeds of variety HUW -468 were soaked for 12 hours in solutions of Mg(NO3)2 (macro nitropriming, C1), H3BO3 (micro nutripriming, C2), combination of Mg(NO3)2 + H3BO3 (combined nutripriming C3), distilled water (hydropriming, C4) for priming purpose. Thereafter all the four sets are dehydrated under forced air and used for experimentation. Various parameters like germination percentage, germination parameters includes: FGP, MGT, GI, GRI, CVG, MGR, plumule, radicle and seedling lengths, fresh and dry weights of radicle & plumule, alpha amylase activity, soluble sugar contents and seedling vigour (index I and II) were determined at 3, 5, 7 and 9th days of seed germination and seedling growth and were compared with non- primed control sets (C0). Result concluded that magnesium nitrate primed seeds (C1) showed better result for all the parameters mentioned except alpha amylase activity & soluble sugar content, later two parameters were best in boric acid (C2) primed one. However, seeds primed with combination of magnesium nitrate and boric acid (C3) showed best result in radicle length and fresh & dry weights of it. In all the observed parameters it was noted that macro and micro primed sets performed better alone or in combination than hydro primed and non-primed control sets.