Calcium carbonate inorganic compound, is one of the most common minerals found in rock agglomerates throughout the world and consists mainly of: calcium, carbon, oxygen. It is the primary component of eggshells, snails, pearls and marine organisms. Calcium carbonate is the active ingredient in agricultural lime and is created when calcium ions in hard water react with carbonate ions to create limescale.

Calcium carbonate in dietary supplements is mainly used as:

A concentrated source of calcium

A gastric buffering agent

A technological excipient

An indirect support for mineral metabolism

The name "calcium carbonate" is derived from its chemical composition: one calcium ion combined with one carbonate ion.

Calcium carbonate is not typically synthesized in a laboratory or industrial setting because it is readily available in nature. However, it can be synthesized by mixing solutions of calcium ions and carbonate ions. The resulting precipitate is calcium carbonate.

Here is a simple example of how this can be done:

• Preparation of solutions. A solution of calcium chloride (CaCl₂) and another solution of sodium carbonate (Na₂CO₃). These are the sources of the calcium ions and carbonate ions, respectively.
• Mixing of solutions. A sodium carbonate solution is added to the calcium chloride solution while the compounds are mixed.
• Formation of precipitate. As the solutions mix, a precipitate of calcium carbonate forms. The reaction is: CaCl₂ + Na₂CO₃ -> CaCO₃ + ₂NaCl.
• Isolation of product. The calcium carbonate precipitate can be collected by filtration, then washed and dried to obtain the pure compound.

It appears in the form of a white powder  insoluble in water colorless, odorless and tasteless.

What it is used for and where

Food

Ingredient included in the list of European food additives as  dye E170.

Constructions (cement, plasters, asphalt).

The use of calcium carbonate precipitate protect concrete surface against the ingress of harmful external agents (1).

Medical

The synthesised biobased Calcium carbonate nanocrystals had demonstrated to be an effective carrier for delivery of anticancer drug doxorubicin (DOX). Findings suggest that Calcium carbonate nanocrystals hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy (2).

Dentin hypersensitivity reduction in adults with a clinical diagnosis of dentin hypersensitivity (3).and indicated as a treatment in cases of calcium deficiency in elderly subjects and in combination with therapies for osteoporosis (4). Calcium carbonate is able to increase calcium levels and neutralise plaque acids (5).

Cosmetics

It is a restricted ingredient as IV/124  a Relevant Item in the Annexes of the European Cosmetics Regulation 1223/2009.

• Abrasive agent. It contains abrasive particles to remove stains or biofilm that accumulate on the stratum corneum or teeth. Baking soda, kieselguhr, silica and many others have abrasive properties. Peeling or exfoliating products used in dermatology or cosmetic applications contain abrasive agents in the form of synthetic microspheres, however these microspheres or abrasive particles are not biodegradable and create pollution in aquatic ecosystems.
• Buffering agent. It is an iingredient that can bring an alkaline or acid solution to a certain pH level and prevent it from changing, in practice a pH stabiliser that can effectively resist instability and pH change.
• Bulking agent. It regulates the water content, dilutes other solids, can increase the volume of a product for better flow, acts as a buffer against organic acids, helps to keep the pH of the mixture within a certain level.
• Opacifying agent. It is useful into formulations that may be translucent or transparent to make them opaque and less permeable to light.
• Oral care agent. This ingredient can be placed in the oral cavity to improve and/or maintain oral hygiene and health, to prevent or improve a disorder of the teeth, gums, mucous membrane. It provides cosmetic effects to the oral cavity as a protector, cleanser, deodorant.

Safety. It is an ingredient that has no particular health warnings and can therefore be used in all cosmetic products.

and is widely used by industries:

• Adhesives, sealants
• Rugs
• Environment (process of desulfurization of combustion gases)
• Fertilizers
• Food and pharmaceutical
• Glass and ceramics
• Products for the home
• Paints and surface coatings
• Paper
• Plastics and composites
• Rubber and elastomers

Calcium carbonate studies

Typical commercial product characteristics Calcium carbonate

Appearance	White powder
pH	9.0-10.5
Boiling Point	333.6ºC at 760mmHg
Melting Point	825°C
Flash Point	197ºC
Density	2.93 g/mL at 25 °C(lit.)
Refraction Index	1.6583
PSA	63.19000
HCL insoluble content	≤0.20%
Volatile content below 105℃	≤1.00
Free Alkali	≤0.10%
Whiteness degree	≥90%
Oil Absorption	50-60ml/g
Sedimentation volume	≥2.2-2.8 ml/g
Fe	≤0.12%
Mn	≤0.01%
Average Particle	0.5-15um
Mesh	400/800/1000/1250/1500
Safety

• Molecular Formula   CCaO₃  CaCO₃
• Molecular Weight  100.086 g/mol
• Exact Mass    101.962982
• CAS    471-34-1
• UNII    H0G9379FGK
• EC Number   207-439-9
• DSSTox Substance ID  DTXSID3036238    DTXSID9050486    DTXSID90109374    DTXSID80163829
• IUPAC  calcium;carbonate
• InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2 
• InChl Key      VTYYLEPIZMXCLO-UHFFFAOYSA-L
• SMILES   C(=O)([O-])[O-].[Ca+2]
• MDL number  MFCD00010906
• PubChem Substance ID    329749202
• ChEBI  3311
• ICSC    1193
• RXCUI    1897  
• RTECS   EV9580000    FF9335000
• Beilstein      8008338
• NCI  C332

Synonyms :

• CI 77220
• Calcite (Ca(Co3))
• Aragonite
• Cupric carbonate
• C50 (carbonate)
• Carbonic acid, calcium salt (1:1)

References____________________________________________________________________

(1) Van Tittelboom K, De Belie N, De Muynck W, Verstraete W. 2010. Use of bacteria to repair cracks in concrete. Cem. Concr. Res. 40:157–166. 10.1016/j.cemconres.2009.08.025

Abstract. As synthetic polymers, currently used for concrete repair, may be harmful to the environment, the use of a biological repair technique is investigated in this study. Ureolytic bacteria such as Bacillus sphaericus are able to precipitate CaCO3 in their micro-environment by conversion of urea into ammonium and carbonate. The bacterial degradation of urea locally increases the pH and promotes the microbial deposition of carbonate as calcium carbonate in a calcium rich environment. These precipitated crystals can thus fill the cracks. The crack healing potential of bacteria and traditional repair techniques are compared in this research by means of water permeability tests, ultrasound transmission measurements and visual examination. Thermogravimetric analysis showed that bacteria were able to precipitate CaCO3 crystals inside the cracks. It was seen that pure bacteria cultures were not able to bridge the cracks. However, when bacteria were protected in silica gel, cracks were filled completely.

(2) Shafiu Kamba A, Ismail M, Tengku Ibrahim TA, Zakaria ZA. A pH-sensitive, biobased calcium carbonate aragonite nanocrystal as a novel anticancer delivery system. Biomed Res Int. 2013;2013:587451. doi: 10.1155/2013/587451.

(3) Collins JR, Richardson D, Sotero K, Mateo LR, Mauriz I. Beneficial effects of an arginine-calcium carbonate desensitizing paste for treatment of dentin hypersensitivity. Am J Dent. 2013 Apr;26(2):63-7.

Abstract. Purpose: To evaluate the clinical efficacy of a single professional application of a Pro-Relief desensitizing fluoride-free paste containing 8% arginine and calcium as compared to a fluoride-free prophylaxis paste on dentin hypersensitivity reduction in adults with a clinical diagnosis of dentin hypersensitivity. Methods: This single-center, parallel group, double-blind and randomized clinical study conducted in Santo Domingo, Dominican Republic included 50 (25 per group) adult male and female subjects. Each study subject had two teeth hypersensitive to air blast stimuli when applied directly at its cervical surface (gingivo-facial 1/3). An air blast hypersensitivity score equal or greater to 2 (Schiff Cold Air Sensitivity Scale) was randomly assigned to one of two treatment groups (1) Pro-Relief in-office desensitizing fluoride-free paste containing 8% arginine and calcium carbonate (Test Paste group), and (2) a fluoride-free prophylaxis paste (Control Paste group). Prior to their baseline examination, subjects were instructed to return to the clinical facility having refrained from eating and drinking for 2 hours. An assessment of air blast hypersensitivity and examinations of oral soft and hard tissue were performed at the baseline. Subjects were provided a professional in-office prophylaxis with their assigned prophylaxis paste. A post hypersensitivity examination was performed immediately after the oral prophylaxis. Results: All subjects completed the study. At the post-hypersensitivity examination, subjects assigned to the Test Paste group and Control Paste group both exhibited statistically significant (P = 0000) reductions (compared to baseline), to air blast hypersensitivity of 44.7% and 25.6%, respectively. At the post-hypersensitivity examination, subjects in the Test Paste group exhibited a statistically significant (P = 0.005) reduction of 24.4% in mean air blast hypersensitivity scores as compared to the Control Paste group.

(4) Wang J, Tao S, Jin X, Song Y, Zhou W, Lou H, Zhao R, Wang C, Hu F, Yuan H. Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy. Theranostics. 2020 Jul 9;10(19):8591-8605. doi: 10.7150/thno.45142.

(5) Lynch RJ, ten Cate JM. The anti-caries efficacy of calcium carbonate-based fluoride toothpastes. Int Dent J. 2005;55(3 Suppl 1):175-8. doi: 10.1111/j.1875-595x.2005.tb00055.x.

Abstract. Aim: To summarise clinical support for the anti-caries efficacy of fluoride toothpastes containing sodium monofluorophosphate (SMFP) and to discuss the possible means by which the abrasive particles in calcium carbonate-based SMFP toothpastes might complement and/or enhance fluoride efficacy. Background: The anti-caries efficacy of fluoride has been proven beyond any reasonable doubt, and the efficacy of SMFP, when incorporated into a variety of compatible toothpaste formulations, has been established in numerous clinical trials. Calcium carbonate-based toothpastes may also influence caries by effecting an increase in plaque calcium levels; an inverse relationship between plaque calcium and caries is well-established. It has also been reported that plaque fluoride levels are dependent on plaque calcium levels. Hence elevated plaque calcium resulting from the use of calcium carbonate-based toothpastes has the potential to elevate plaque fluoride, itself linked to reduced caries experience. It has been shown that calcium carbonate particles are retained by plaque and this may also influence caries by neutralising harmful plaque acids and concurrently liberating calcium. Conclusion: Fluoride delivered from calcium carbonate-based SMFP toothpastes is an effective means of reducing caries. Further, calcium carbonate may confer additional benefits through elevation of oral calcium levels and neutralisation of plaque-acids.