App Tiiips monitors calories, dangerous ingredients
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"Descrizione" by Al222 (18103 pt) | 2023-Dec-30 21:20 |
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Il cancro al colon è una delle malattie più diffuse al mondo, la seconda più letale e la terza più diagnosticata al mondo. Il cancro al colon, come molte altre forme di cancro, è prevedibile, soprattutto perché la dieta e l'alimentazione sono fattori chiave nella modulazione del rischio di cancro (1).
Componenti che aiutano nella protezione del colon sono sostanze che possono contribuire a mantenere la salute del colon e prevenire problemi intestinali. Ecco alcuni esempi
L'effetto protettivo è attribuibile ad una dieta che includa alimenti contenenti un alto contenuto di polifenoli come frutta e verdura (3).
Componenti che possono contribuire o esacerbare le malattie del colon includono vari fattori che possono aumentare il rischio di problemi intestinali. Ecco alcuni esempi:
Le notizie fornite sul sito Tiiips sono solo a scopo informativo e non devono sostituire il parere del medico che occorre sempre consultare prima di prendere decisioni relative alla salute.
Bibliografia________________________________________________________________________
(1) Forman MR, Hursting SD, Umar A, Barrett JC. Nutrition and cancer prevention: a multidisciplinary perspective on human trials. Annu Rev Nutr. 2004;24:223-54. doi: 10.1146/annurev.nutr.24.012003.132315. PMID: 15189120.
Abstract. More than one million Americans were expected to be diagnosed with cancer in 2003 (7a). Compelling experimental, epidemiological, and clinical evidence indicates that many cancers are preventable, especially because diet and nutrition are key factors in the modulation of cancer risk. The road to nutritional intervention in cancer prevention has led to successful trials as well as trials that did not reach their intended endpoints. This chapter reviews four case studies of trials, with two ending in success and two ending in null findings or adverse effects. The goal is to identify lessons learned from all four case studies and from the investigations of the complexities inherent to nutritional intervention trials. Additional insights are presented by the research addressing potential mechanisms underlying the endpoints of human trials. Future progress in nutrition and cancer prevention will require expertise from multidisciplinary teams to develop new knowledge about specific nutrients and dietary modifications within a framework of interaction between animal and human research.
(2) Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr. 2001 Feb;73(2 Suppl):451S-455S. doi: 10.1093/ajcn/73.2.451s.
Abstract. Ingestion of viable probiotics or prebiotics is associated with anticarcinogenic effects, one mechanism of which is the detoxification of genotoxins in the gut. This mechanism was shown experimentally in animals with use of the rat colon carcinogen 1,2-dimethylhydrazine and by determining endpoints that range from tumorigenesis to induction of DNA damage. Because of the complexity of cancer initiation, cancer progression, and the exposure of cancer in the gut, many types of interactions may be envisaged. Notably, some of our newer studies showed that short-lived metabolite mixtures isolated from milk that was fermented with strains of Lactobacillus bulgaricus and Streptococcus thermophilus are more effective in deactivating etiologic risk factors of colon carcinogenesis than are cellular components of microorganisms. Ingestion of prebiotics results in a different spectrum of fermentation products, including the production of high concentrations of short-chain fatty acids. Gut flora, especially after the ingestion of resistant starch, induces the chemopreventive enzyme glutathione transferase pi in the colon of the rat. Together, these factors lead to a reduced load of genotoxic agents in the gut and to an increased production of agents that deactivate toxic components. Butyrate is one such protective agent and is associated with lowering cancer risk. It was recently shown that buytrate may inhibit the genotoxic activity of nitrosamides and hydrogen peroxide in human colon cells. In humans, the ingestion of probiotics leads to the excretion of urine with low concentrations of components that are genotoxic in human colon cells and high concentrations of components that induce oxidized DNA bases.
(3) Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Araújo JR, Gonçalves P, Martel F. Nutr Res. 2011 Feb;31(2):77-87. doi: 10.1016/j.nutres.2011.01.006.
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