Sucrose Cocoate is a chemical compound, an aliphatic carboxylic ester of sucrose, a mixture of sucrose esters of coconut fatty acids in an aqueous ethanol solution.

It occurs as an odourless white powder or white to yellowish paste.

Incompatible with strong oxidising agents

What it is used for and where

Medical

Transdermal administration of nasal and ocular drugs.

Cosmetics

Non-ionic surfactant, emollient and moisturising agent, PEG-free, increases viscosity and foaming density in liquid soaps with slight thickening effect.

Skin conditioning agent - Emollient. Emollients have the characteristic of enhancing the skin barrier through a source of exogenous lipids that adhere to the skin, improving barrier properties by filling gaps in intercorneocyte clusters to improve hydration while protecting against inflammation. In practice, they have the ability to create a barrier that prevents transepidermal water loss.  Emollients are described as degreasing or refreshing additives that improve the lipid content of the upper layers of the skin by preventing degreasing and drying of the skin. The problem with emollients is that many have a strong lipophilic character and are identified as occlusive ingredients; they are oily and fatty materials that remain on the skin surface and reduce transepidermal water loss. In cosmetics, emollients and moisturisers are often considered synonymous with humectants and occlusives.

Surfactant - Emulsifying agent. Emulsions are thermodynamically unstable. Emulsifiers have the property to reduce the oil/water or water/oil interfacial tension, improve emulsion stability and also directly influence the stability, sensory properties and surface tension of sunscreens by modulating their filmometric performance.

Improves and amalgamates the mixture in lotions and creams.

Percentages in formulations: detergents 0.7 - 4%, emulsions, creams 3 -5%.

Data sheet:   https://www.makingcosmetics.us/msds/sds-sucrose-cocoate.pdf

Sucrose Cocoate studies

Typical optimal commercial product characteristics  Sucrose Cocoate

Appearance	White fine powder
Density 20°C	1.07 g/cm3
pH  (20oC) 50g/l water	7.0
Flash Point	180°C
Specific Gravity	1.0 g/cm3
Assay	99.0%~101.0% anhydrous
Purity	≥99.0%
Sulphated ash	≤0.1%/g
Residue on ignition	≤0.03%
Heavy metals	≤10 ppm
Total Impurities	≤0.5%
Water	≤1.0%
Storage	Cool and dry area, preventing sunlight, air-flowing
Safety

• Molecular Formula  
• Molecular Weight     
• CAS  91031-88-8
• UNII    3H18P0UK73
• EC Number   292-993-4
• DSSTox Substance ID  
• IUPAC  
• InChI=1S// 
• InChl Key      MOSFIJXAXDLOML-UHFFFAOYSA-N
• SMILES   
• MDL number  

Synonyms:

• alpha-D-Glucopyranoside, beta-D-fructofuranosyl, cocoate
• Fatty acids, coco, esters with sucrose
• TEGOSOFT® LSE 65 K Soft

Compendium of the most significant studies with reference to properties, intake, effects.

Tavano L, Muzzalupo R, Cassano R, Trombino S, Ferrarelli T, Picci N. New sucrose cocoate based vesicles: Preparation, characterization and skin permeation studies. Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):319-22. doi: 10.1016/j.colsurfb.2009.09.003.

Abstract. A commercial sucrose cocoate surfactant was used to obtain a new vesicular system for transdermal drug delivery. The preparation, the dimensional and morphological characterizations and the skin permeation profile of these new niosomes were evaluated.

Vucinić-Milanković N, Savić S, Vuleta G, Vucinić S. The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. Drug Dev Ind Pharm. 2007 Mar;33(3):221-34. doi: 10.1080/03639040601150179.

Abstract. Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. 

Ahsan F, Arnold JJ, Meezan E, Pillion DJ. Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption. Int J Pharm. 2003 Jan 30;251(1-2):195-203. doi: 10.1016/s0378-5173(02)00597-5.

Abstract. In order to determine its potential utility in enhancing nasal and ocular drug delivery, absorption studies were performed in anesthetized Sprague-Dawley male rats with calcitonin and insulin, two distinct therapeutic peptides.