Sodium acid carbonate is commonly used as a leavening agent in baked products, but it has some very specific applications including the cases of glutathione synthetase deficiency, a rare congenital defect of glutathione metabolism. He demonstrated with effective results (1).
Also used as a bleach in various formulas, including those used in toothpaste (2).
Sodium carbonate and chitosan (3).
This randomized, examiner-blind, crossover clinical study compared the plaque removal efficacy of three experimental toothpastes containing 20%, 35%, and 50% w/w sodium bicarbonate (NaHCO3) with commercial toothpastes containing 67% and 0% w/w NaHCO3 (positive and negative controls, respectively). There was no statistically significant difference in change in mean Quigley-Hein Plaque Index score between toothpastes containing 67% w/w NaHCO3 and 0% w/w NaHCO3 following a single timed brushing. This unexpected observation may be attributed to lower than expected reduction in overall plaque and a possible Hawthorne effect. As study validation was not met, no further conclusions can be made. The study products were generally well tolerated (4).
