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Al222
Al222 (24918 pt) 2026-Aug-05 14:55

Vitis vinifera seed oil: properties, uses, pros, cons, safety

Vitis Vinifera Seed Oil, commonly known as grape seed oil, is the fixed oil obtained from the seeds of Vitis vinifera (Vitaceae). In cosmetics it is used mainly as an emollient and skin conditioning ingredient, as also reported in the attached CosIng screenshot. It is a light vegetable oil, rich in fatty acid triglycerides, particularly appreciated in skin care, hair care, massage oils, body products, emulsions, facial oils, balms, and formulas where a not-too-heavy skin feel is desired.

Description

Grape seed oil is a plant-derived raw material obtained from grape seeds, often as a valorization of by-products from the wine industry. From a chemical standpoint, it is not a single molecule, but a natural mixture of triglycerides, with a very high proportion of unsaturated fatty acids, especially linoleic acid, and smaller amounts of oleic, palmitic, stearic, and other minor components.

In cosmetics, its main role is emollient: it helps make the skin softer, reduces the feeling of superficial dryness, and improves formula spreadability. Compared with heavier oils or oils very rich in saturated fatty acids, it tends to be perceived as lighter and less greasy, although the real sensory profile depends on refining grade, quality, oil blend, and percentage of use.

It is important to distinguish grape seed oil from grape seed extract. The oil is mainly lipidic; the extract may instead be richer in polyphenols, procyanidins, and water-soluble or hydroalcohol-soluble compounds. Many strong antioxidant claims referring to “grape seed extract” cannot be automatically transferred to the simple oil.

Production process

Production starts from grape seeds. After separation from grape pomace, the seeds are cleaned, dried, and subjected to mechanical pressing or solvent extraction, possibly followed by refining. Some technical sheets describe refined grape seed oil as a fatty oil obtained from the seeds of Vitis vinifera by extraction or expression and subsequent refining.

Cold pressing is more valued commercially because it limits solvent use and may better preserve some minor fractions, but it often provides lower yields. Solvent extraction can increase yield, but requires strict control of residues. Refining can improve color, odor, stability, and purity, but may reduce some naturally occurring minor compounds.

After extraction, the usual steps include filtration, possible neutralization, bleaching, deodorization, and control of acidity, peroxide value, iodine value, fatty acid profile, solvent residues, pesticides, heavy metals, and oxidative stability.

Main compounds present

Vitis Vinifera Seed Oil consists mainly of triglycerides containing fatty acids:

  • linoleic acid, normally the main one;

  • oleic acid;

  • palmitic acid;

  • stearic acid;

  • small amounts of linolenic acid and other minor fatty acids;

  • unsaponifiable fraction with tocopherols, phytosterols, and minor compounds in variable amounts.

The literature reports that grape seed oil is rich in unsaturated fatty acids and that its content may vary depending on grape variety and growing conditions. A 2022 paper indicates, as approximate ranges, about 61-73% linoleic acid, 14-25% oleic acid, and a very low proportion of linolenic acid, with about 85-90% total unsaturated fatty acids.

Identification data and specifications

CharacteristicValueNote
INCI nameVitis Vinifera Seed Oilcosmetic designation
Common namegrape seed oilcommon designation
Botanical nameVitis viniferaEuropean grapevine
Botanical familyVitaceaebotanical family
Part usedseedsgrape seeds
Chemical categoryvegetable oil / fatty acid triglyceridesnatural mixture, not a single molecule
CAS85594-37-2 / 84929-27-1 / 8024-22-4from the attached CosIng screenshot and technical sheets
EC287-896-9 / 284-511-6 / -from the attached CosIng screenshot and technical sheets
CosIng Ref.80653reported by INCI databases
CosIng functionsskin conditioning - emollient; skin conditioningfrom the attached CosIng screenshot
INCI descriptionfixed oil consisting mainly of fatty acid glycerides, obtained by pressing grape seedsdescription reported in INCI databases
Food useedible oil, if food gradenutritional/culinary use, distinct from cosmetic grade
Visible specific cosmetic restrictionsnone in the attached screenshotfinished product assessment remains necessary


Indicative physicochemical and compositional properties

CharacteristicIndicative valueNote
Appearanceclear oily liquidtypical of vegetable oils
Colorpale yellow to green-yellow or light yellowdepends on refining and batch
Odormild, characteristic, oilymore neutral in refined grades
Water solubilityinsolublerequires emulsion or oil phase
Oil solubilitymiscible with vegetable oils and lipophilic estersuseful in fatty phases
Densityabout 0.91-0.93 g/mLtypical indicative value for vegetable oils
Acidityvariablecheck acid value/FFA
Peroxide valuecritical parameterindicates oil oxidation
Main profilerich in linoleic acidvariable by origin and grade
Oxidative stabilitymoderate, to be controlledhigh proportion of polyunsaturated fatty acids
Cosmetic skin feellight, emollient, spreadabledepends on formula and refining
Main technical riskrancidity/oxidationprotect from air, light, and heat


Food

In the food sector, grape seed oil may be used as an edible oil, if produced and marketed as food grade. It is rich in unsaturated fatty acids, especially linoleic acid, and may be used in dressings, cold preparations, and some culinary applications. However, food grade must be distinguished from cosmetic grade: the same botanical designation is not enough to guarantee suitability for consumption.

From a nutritional standpoint, the favorable profile is mainly linked to the presence of unsaturated fatty acids. However, like all oils, it remains a very calorie-dense food and should be used in reasonable amounts. The high proportion of polyunsaturated fatty acids also requires attention to storage, because oxidation can worsen sensory and nutritional quality.

The benefits of grape seed extracts should not be automatically attributed to grape seed oil. The extract may be much richer in procyanidins and polyphenols, whereas the oil is mainly a lipid fraction. Some reviews indicate interest in grape seed oil in food and cosmetic contexts, but many biological activities are observed mainly in in vitro or experimental studies and should not automatically become health claims for the finished product.

Cosmetics

In cosmetics, Vitis Vinifera Seed Oil is used as an emollient and skin conditioning agent. It may appear in face creams, body lotions, massage oils, oil serums, lip balms, hair products, masks, cleansing oils, body butters, make-up, and products for skin requiring a relatively light oil.

The emollient function consists of improving softness, spreadability, and superficial comfort. It can also help reduce the feeling of dryness and improve the distribution of other lipophilic ingredients. In hair products it can help make the fiber softer and shinier, especially in leave-on products or nourishing masks.

Vitis Vinifera Seed Oil is not a fragrance and is not among fragrance allergens. The main issue is therefore not allergen labeling, but oxidative quality: an old, oxidized, or poorly stored oil may have an unpleasant odor and a higher irritant potential.

Pros

  • It is a light and versatile vegetable oil.

  • It works well as an emollient and skin conditioning ingredient.

  • It has a good linoleic acid content, useful for the cosmetic profile of light oils.

  • It can improve skin softness, spreadability, and comfort.

  • It can be used in skin care, body care, hair care, make-up, and massage oils.

  • It derives from grape seeds, often as a valorization of by-products from the wine industry.

  • It is not a fragrance allergen and has no perfuming function.

  • CIR indicated that Vitis Vinifera Seed Oil and Hydrogenated Grapeseed Oil had been assessed and concluded safe as used in cosmetics.

Cons

  • It is not a strong dermatological active: its function is mainly emollient and formulation-related.

  • Its high proportion of unsaturated fatty acids makes it more sensitive to oxidation than more saturated oils.

  • It may become rancid if exposed to light, air, heat, or prolonged storage.

  • Quality varies greatly between refined, virgin, cold-pressed, or solvent-extracted oil.

  • Antioxidant claims should not be overstated: the oil is not equivalent to grape seed extract.

  • On very sensitive or acne-prone skin, as with any oil, tolerability must be verified in the finished product.

  • If intended for food use, food grade is required; cosmetic grade must not be consumed.

  • Plant origin does not automatically guarantee sustainability, absence of pesticides, or high quality.

Safety, regulatory aspects, and environment

From a cosmetic standpoint, Vitis Vinifera Seed Oil is generally considered a low-concern ingredient when fresh, well stored, compliant with cosmetic grade, and used in properly assessed formulas. CIR reports that the safety of Vitis Vinifera Seed Oil and Hydrogenated Grapeseed Oil had already been assessed in 2011, with a conclusion of safety as used in cosmetics. A later CIR publication on Vitis vinifera derivatives also reports that the evaluated grape-derived ingredients function mainly as skin-conditioning agents and were considered safe under the assessed cosmetic practices of use and concentration.

The most important practical risk is oxidation. An oxidized oil can worsen odor, color, formula stability, and skin tolerability. For this reason, peroxide value, acid value, storage in tightly closed containers, protection from light and heat, use within shelf life, and, where appropriate, formulation antioxidants such as tocopherol are important.

No specific cosmetic provisions are shown in the “Cosmetics Regulation provisions” section of the attached CosIng screenshot. This does not remove the obligation to perform a safety assessment of the finished cosmetic product: concentration, oil quality, possible impurities, product category, application area, stability, and compatibility with the rest of the formula must always be considered.

From an environmental standpoint, grape seed oil is interesting because it may valorize seeds obtained as a by-product of grape and wine processing. However, the real profile depends on grape cultivation, pesticide use, drying/extraction energy, extraction method, refining, transport, packaging, and waste management. Origin as a by-product is favorable, but not sufficient on its own to demonstrate overall sustainability.

For correct cosmetic use, it is advisable to request from the supplier:

  • updated SDS;

  • certificate of analysis;

  • fatty acid profile;

  • acid value / free fatty acids;

  • peroxide value;

  • iodine value;

  • color and odor;

  • possible solvent residues;

  • pesticides and heavy metals, when relevant;

  • geographical origin and extraction method;

  • cosmetic-grade declaration;

  • possible organic, COSMOS, vegan, or palm-free certification, if claimed;

  • shelf life and storage conditions.

Conclusion

Vitis Vinifera Seed Oil is a very useful cosmetic vegetable oil as an emollient and skin conditioning agent. Its main value is formulation-related and sensory: it makes the skin softer, improves spreadability, and allows the creation of oil-based or emulsified formulas with a relatively light touch.

Professional assessment must avoid two simplifications: not all benefits of grape seed extracts automatically apply to the oil, and not all grape seed oils have the same quality. The decisive points are extraction method, refining, fatty acid profile, peroxide value, acidity, freshness, storage, origin, and supplier documentation.

In a well-designed formula, with fresh and controlled oil, Vitis Vinifera Seed Oil is generally a favorable and versatile ingredient. The points to control are oxidation, purity, stability, SDS, COA, formulation compatibility, concentration in the finished product, and consistency between cosmetic or food grade and intended use.

References


(1) Chuang CC, McIntosh MK. Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. 2011 Aug 21;31:155-76. doi: 10.1146/annurev-nutr-072610-145149. 

Abstract. Obesity and metabolic disease-related health problems (e.g., type 2 diabetes, atherosclerosis, and hypertension) are the most prevalent nutrition-related issues in the United States. An emerging feature of obesity and type 2 diabetes is their linkage with chronic inflammation that begins in white adipose tissue and eventually becomes systemic. One potential strategy to reduce inflammation and insulin resistance is consumption of polyphenol-rich foods like grapes or their by-products, which have anti-inflammatory properties. Polyphenols commonly found in grape products have been reported to reduce inflammation by (a) acting as an antioxidant or increasing antioxidant gene or protein expression, (b) attenuating endoplasmic reticulum stress signaling, (c) blocking proinflammatory cytokines or endotoxin-mediated kinases and transcription factors involved in metabolic disease, (d) suppressing inflammatory- or inducing metabolic-gene expression via increasing histone deacetylase activity, or (e) activating transcription factors that antagonize chronic inflammation. Thus, polyphenol-rich grape products may reduce obesity-mediated chronic inflammation by multiple mechanisms, thereby preventing metabolic diseases.

(2) Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010 Mar;103(5):730-4. doi: 10.1017/S0007114509992364. 

Abstract. Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomised, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action.

(3) PKwon GT, Jung JI, Song HR, Woo EY, Jun JG, Kim JK, Her S, Park JH. Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 2012 Mar;23(3):228-38. doi: 10.1016/j.jnutbio.2010.11.019. Epub 2011 Apr 15. PMID: 21497499.

(4) Darwish AG, El-Sharkawy I, Tang C, Rao Q, Tan J. Investigation of Antioxidant and Cytotoxicity Activities of Chocolate Fortified with Muscadine Grape Pomace. Foods. 2023 Aug 22;12(17):3153. doi: 10.3390/foods12173153. 

Abstract. Muscadine grape pomace and mixed products with chocolate extracts from three muscadine genotypes exhibiting different berry skin colors (black and bronze) were investigated for total phenolic content (TPC), total flavonoid content (TFC), DPPH, FRAP antioxidant activity, and anticancer activity using MDA-MB-468 (MM-468; African American) breast cancer cells. Muscadine berry extracts and mixed products showed cytotoxicity activities of up to 70% against MM-468 breast cancer cells. Cell growth inhibition was higher in 'macerated Floriana' with an IC50 value of 20.70 ± 2.43 followed by 'Alachua' with an IC50 value of 22.25 ± 2.47. TPC and TFC in macerated MGP powder were (1.4 ± 0.14 and 0.45 ± 0.01 GAE/g FW, respectively), which was significantly higher than those in cocoa powder. Data analysis showed a high association between DPPH, FRAP antioxidant activities, and TPC content and a positive high correlation between anticancer activity and antioxidant capacity and between TPC and anticancer activity. The anticancer and antioxidant effects of muscadine grape pomace and chocolate extracts are attributed to the TPC of extracts, which showed a stronger positive correlation with growth inhibition of African American breast cancer cells. This study would be of great value for food industries as well as other manufacturers who are interested in new food blends.

(5) Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019 Feb 28;66(1):13-21. doi: 10.18388/abp.2018_2749. PMID: 30816367.

 Abstract. Resveratrol is a polyphenol that is abundant in grape skin and seeds. Food sources of resveratrol include wine, berries, and peanuts. This compound has many properties, including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, and aging. Because resveratrol is generally welltolerated, it is believed to be a promising compound in preventing many diseases, such as diabetes and its complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize the latest information on the multiple effects of resveratrol on health and the benefits of its intake, based on in vitro and in vivo studies in animals and humans.

 de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005 May;49(5):405-30. doi: 10.1002/mnfr.200500022. 

  Abstract. Resveratrol is a phytoalexin polyphenolic compound found in various plants, including grapes, berries, and peanuts. Multiple lines of compelling evidence indicate its beneficial effects on neurological, hepatic, and cardiovascular systems. Also one of the most striking biological activities of resveratrol soundly investigated during the late years has been its cancer-chemopreventive potential. In fact, recently it has been demonstrated that this stilbene blocks the multistep process of carcinogenesis at various stages: tumor initiation, promotion, and progression. One of the possible mechanisms for its biological activities involves downregulation of the inflammatory response through inhibition of synthesis and release of pro-inflammatory mediators, modification of eicosanoid synthesis, inhibition of activated immune cells, or inhibiting such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via its inhibitory effects on nuclear factor (kappa)B (NF-(kappa)B) or the activator protein-1 (AP-1). More recent data provide interesting insights into the effect of this compound on the lifespan of yeast and flies, implicating the potential of resveratrol as an anti-aging agent in treating age-related human diseases. It is worthy to note that the phenolic compound possesses a low bioavailability and rapid clearance from the plasma. As the positive effects of resveratrol on inflammatory response regulation may comprise relevant clinical implications, the purpose of this article is to review its strong anti-inflammatory activity and the plausible mechanisms of these effects. Also, this review is intended to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan.