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admin (19653 pt) 2024-Oct-18 09:11

Saccharomyces/Hippophae Rhamnoides Fruit Ferment Filtrate is a filtrate obtained from the fermentation of Hippophae rhamnoides (sea buckthorn) fruit with Saccharomyces yeast. This bioactive fermentation process enriches the filtrate with fermented nutrients, antioxidants, vitamins, and regenerative compounds that promote skin health. Thanks to its regenerative, moisturizing, and protective properties, the filtrate is widely used in cosmetic formulations to improve skin elasticity and radiance.

Chemical Composition and Structure

The fermentation filtrate contains a combination of amino acids, peptides, vitamins (particularly vitamin C and E), antioxidants, and bioactive compounds derived from sea buckthorn fruit and the fermentation process. Fermentation enhances the bioavailability of these nutrients, allowing for better skin absorption. The enzymes and peptides contribute to cellular renewal and protection against oxidative damage.

Physical Properties

Saccharomyces/Hippophae Rhamnoides Fruit Ferment Filtrate is a clear or slightly cloudy liquid, pale yellow in color, with a faint natural fragrance. It is water-soluble and easily used in serums, lotions, creams, and other cosmetic products. With its lightweight texture, it absorbs quickly into the skin, delivering hydration without leaving an oily residue.

Production Process

The filtrate is obtained through controlled fermentation of sea buckthorn fruit using Saccharomyces yeast. During the fermentation process, the nutrients and antioxidants in the fruit are transformed into more bioavailable compounds that are more easily absorbed by the skin. The final product is a nutrient-rich filtrate that is purified to ensure high quality.

  • Cultivation of Saccharomyces: Saccharomyces strains are cultivated in a specific growth medium optimized for the proliferation of yeast. This phase is crucial to ensure adequate production of active metabolites during the fermentation process.

  • Preparation of Hippophae Rhamnoides: The fruits of Hippophae rhamnoides are harvested and cleaned to remove dirt and impurities. This step is essential to ensure the quality of the final extract.

  • Fermentation: The fruits of Hippophae rhamnoides are added to the growth medium containing Saccharomyces. The mixture is incubated under controlled temperature and pH conditions to promote the fermentation process. During this process, the yeast converts the nutrients present in the fruits into beneficial metabolites.

  • Filtration: After the fermentation period, the mixture is filtered to remove undissolved solids, resulting in a liquid filtrate rich in nutrients and bioactive compounds derived from the fermentation.

  • Concentration (If Necessary): The filtrate may be further concentrated through evaporation or other techniques to obtain a product with a higher concentration of active ingredients.

  • Quality Control and Packaging: Finally, the Saccharomyces/Hippophae rhamnoides fruit ferment filtrate undergoes quality control checks to verify its purity, efficacy, and compliance with standards. After analysis, it is packaged for distribution and use in cosmetic products and dietary supplements.

Applications

  • Regenerative Skincare: With the presence of enzymes and peptides, this filtrate is ideal for promoting cell renewal and improving the regeneration of damaged or mature skin.

  • Moisturizing Products: Its moisturizing properties help keep the skin soft and smooth, making it an excellent ingredient in serums and creams for dry or dehydrated skin.

  • Anti-aging Products: The antioxidant and vitamin content helps protect against environmental damage and reduces the appearance of aging signs such as wrinkles and fine lines.

INCI Functions:

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Health and Safety Considerations

Safety in Use
Saccharomyces/Hippophae Rhamnoides Fruit Ferment Filtrate is considered safe for use in cosmetics. No significant side effects or irritations have been reported. Major regulatory authorities, such as the European Union and the FDA, approve its use in cosmetic formulations.

Allergic Reactions
Allergic reactions to this filtrate are rare, but it is always advisable to perform a patch test before use, especially on sensitive or allergy-prone skin.

Toxicity and Carcinogenicity
It is considered safe and beneficial for skin health due to its nourishing and protective properties.

Environmental Considerations
The fermentation process is sustainable and eco-friendly, requiring low energy and producing minimal waste. The filtrate is derived from natural sources, and the fermentation process increases the efficiency of ingredient use.

Regulatory Status
The filtrate is approved for use in cosmetics by major regulatory authorities, including the European Union and the FDA in the United States.


Sea buckthorn (Hippophae rhamnoides) Studies

From the leaves and berries of the sea buckthorn (Hippophae rhamnoides) is extracted chloroform and n-hexane, components with intense antibacterial activity (1).

It is a rich source of vitamins C and E, carotenoids, flavonoids, anthocyanins, organic acids, amino acids, sterols, triterpenols and isoprenols (2) with an antioxidant activity.

The berries produce an oil containing carotenoids, palmitic, palmitolic and oleic acid, while the seed oil is composed of linoleic, linolenic and oleic acid as main components (3) .

This oil has traditionally been used to improve blood circulation and for the treatment of dermatological problems including wounds, gastritis, peptic ulcers, uterine erosion and inflammatory disorders of the genital organs (4).

Sea buckthorn has significant cardioprotective activity and a positive effects on the healing of the cardiovascular system, including inhibition of platelet activation (in particular platelet aggregation), reduction of cholesterol concentration, blood pressure and antioxidant action (5).

In this study, a positive evaluation of the topical effects on atopic lesions as it improved the severity of dermatitis by reducing epidermal thickness (6).

The results of this study on the extract of Sea buckthorn, provide a basis for affordable, low side-effect therapy for the treatment of psoriasis (7).

Cosmetics

It produces a regenerating effect on the skin produced by carotenoids, vitamin E and unsaturated fats contained in the pulp and seeds.

Other applications

It is placed in foods, candies, to give a particular taste.

Sea buckthorn studies

References_______________________________________________________________________

(1) Qadir MI, Abbas K, Younus A, Shaikh RS. Report - Antibacterial activity of sea buckthorn (Hippophae rhamnoides L.) against methicillin resistant Staphylococcus aureus (MRSA). Pak J Pharm Sci. 2016 Sep;29(5):1711-1713. 

Abstract. Objective of the present study was to investigate the antibacterial activity of Sea buckthorn (Hippophae rhamnoides L.) berries and leaves against methicillin resistant Staphylococcus aureus (MRSA) by using the standard disc diffusion method. Chloroform, n-hexane and aqueous extract of the plant parts were used. Doses of 2mg/ml, 4 mg/ml and 6mg/ml were tested against the microorganism, and the zone of inhibition was compared against the standard drug vancomycin. Results indicated that n-hexane and chloroform extracts of berries and n-hexane extract leaves showed significant (p<0.05) antibacterial activity comparable with vancomycin. It was concluded from the study that extracts berries and leaves of Hippophae rhamnoides have antibacterial activity against MRSA.

(2) Yang B, Kallio H. Supercritical CO2-extracted sea buckthorn (Hippophae rhamnoides) oils as new food ingredients for cardiovascular health. In: Proceedings of Health Ingredients of Europe, Paris; 2002, p. 17–19.

(3) Süleyman, Z., Erdemoğlu, N., Küsmenoğlu, Ş., Gürbüz, İ., Yesilada, E., and Çalış, İ. Fatty acid composition and anti-ulcerogenic activity of Hippophae rhamnoides fruit oil. J Fac Pharm Gazi Univ. 1998; 15: 11–17

(4) Li, T.S.C. and Wang, L.C.H. Physiological components and health effects of ginseng, echinacea and sea buckthorn. in: G. Mazza (Ed.) Functional foods, biochemical and processing aspects. Technomic Publishing Company, Lancaster, PA; 1998: 329–356

Abstract. Background: Increased consumer´s interest in health has driven the development of foods that offer specific beneficial effects. The list of foods and ingredients includes essential and non-essential nutrients, plant and marine components, whole foods, microorganisms, microalgae and technological approaches. Traditionally, health outcomes focussed on the prevention of chronic diseases but health targets have expanded to cover areas such as brain health, inflammation, eye health, women´s health, healthy ageing and beauty. Objective: This review highlights, from a nutritional biochemistry perspective, differential aspects on designing and interpreting human studies to support the health effects of functional foods. Results: Despite the available evidence from in vitro, animal and observational studies, welldesigned human studies are necessary to support the health effects of functional foods. Intervention trials with foods are complex as they imply limitations due to methodological, food-related and host-related factors. The use of responsive, validated and clinically relevant markers becomes essential even though there is a lack of reliable biomarkers of exposure for many bioactives. Furthermore, the effect of modulating factors such as subclinical inflammation, gut microbiota and genetic variability should be taken into account. Multiple indicators may provide a more reliable alternative to assess physiological processes while emerging biomarkers (microRNAs, epigenetic changes) constitute a promising approach. Additionally, the magnitude of the change is critical to support any health effect although interventions may have a limited clinical impact but be epidemiologically relevant. Also, based on the available data, the premise that bioactivescontaining foods are safe may be questionable. Conclusion: An integrated approach including multiple biomarkers, genetic variability, effect of gut microbiota and risk/benefit assessment should be used to support the potential health effects of functional foods.

(5) Olas B. Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases. Food Chem Toxicol. 2016 Nov;97:199-204. doi: 10.1016/j.fct.2016.09.008. Epub 2016 Sep 9. PMID: 27616182.

(6) Hou DD, Di ZH, Qi RQ, Wang HX, Zheng S, Hong YX, Guo H, Chen HD, Gao XH. Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation. Skin Pharmacol Physiol. 2017;30(5):268-276. doi: 10.1159/000479528. Epub 2017 Sep 6. PMID: 28873377.

(7) Boca AN, Ilies RF, Saccomanno J, Pop R, Vesa S, Tataru AD, Buzoianu AD. Sea buckthorn extract in the treatment of psoriasis. Exp Ther Med. 2019 Feb;17(2):1020-1023. doi: 10.3892/etm.2018.6983.

Abstract. Psoriasis is one of the most common chronic dermatological conditions, with a strong impact on patients' quality of life. Currently, psoriasis benefits from conventional therapy with a high rate of adverse effects and an increase in non-compliance and self-medication of patients. As such, there is a need to pinpoint low-adverse effects and accessible remedies for this condition. Our single-blind, placebo-controlled study assessed the effect of sea buckthorn extract on psoriasis lesions in previously untreated patients. Our results showed an improvement in Psoriasis Area Severity Index (PASI) scores and in Dermatology Life Quality Index (DLQI) scores when compared to the baseline values, as well as at the 4- and 8-week time marks for the lesions treated with sea buckthorn extract. By contrast, the measurements for the placebo treated lesions showed no alteration at the 4-week mark, and significant worsening at the end of the trial. These findings provide a solid, optimistic base for the in-depth research of sea buckthorn as an adjuvant or a component in psoriasis care protocols.