VLDL lipoproteins are synthesized in hepatocytes. After chylomicrons have been digested, after a meal, lipids carried by remnant chylomicrons along with newly synthesized lipids are used to produce VLDLs.
Apoproteins E, C, and B100 are found on VLDL.
The size of a VLDL is significantly smaller than a chylomicron but the structure is the same.
VLDLs are synthesized in hepatocytes, and their pathway is similar to that of chylomicrons.
The key difference with the chylomicron is that VLDL carries lipids neosynthesized by hepatocytes, whereas the chylomicron carries lipids taken in after a meal. Thus, VLDL serves the replenishment of extrahepatic tissues away from meals.
