Coenzyme Q10 studies

Fillp (3336 pt) • 2019-Nov-08 16:50

Coenzyme Q10 can, in part, improve the inflammatory process. Chronic inflammation contributes to the appearance and development of metabolic diseases. Clinical evidence has suggested that coenzyme Q10 has some effects on inflammatory markers (1).

High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary heart disease. Cardiovascular diseases are the leading cause of death in the world and hyperlipidemia is an important risk factor for these diseases. Higher levels of low-density lipoprotein cholesterol (LDL-C) may increase the incidence of cardiovascular disease (2).

Recently, coenzyme Q10 has been shown to have a cardio-protective impact on these diseases. A higher level of coenzyme Q10 in the plasma (≥ 0.52 mmol / l) was significantly associated with a reduced risk (3).

It is found, together with alpha tocopherol, in royal jelly of bees (4).

Other studies

Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study.

Derosa G, D'Angelo A, Maffioli P.

Drug Des Devel Ther. 2019 Oct 21;13:3647-3655. doi: 10.2147/DDDT.S223153.

Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells.

Mizobuti DS, Fogaça AR, Moraes FDSR, Moraes LHR, Mâncio RD, Hermes TA, Macedo AB, Valduga AH, de Lourenço CC, Pereira ECL, Minatel E.

Cell Stress Chaperones. 2019 Oct 16. doi: 10.1007/s12192-019-01039-2

Coenzyme Q10 Supplementation in Fibrosis and Aging.

Hargreaves IP, Mantle D.

Adv Exp Med Biol. 2019;1178:103-112. doi: 10.1007/978-3-030-25650-0_6.

Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis.

Moccia M, Capacchione A, Lanzillo R, Carbone F, Micillo T, Perna F, De Rosa A, Carotenuto A, Albero R, Matarese G, Palladino R, Brescia Morra V.

Ther Adv Neurol Disord. 2019 Feb 18;12:1756286418819074. doi: 10.1177/1756286418819074.

The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.

Jorat MV, Tabrizi R, Kolahdooz F, Akbari M, Salami M, Heydari ST, Asemi Z.

Inflammopharmacology. 2019 Apr;27(2):233-248. doi: 10.1007/s10787-019-00572-x.

References_________________________________

(1) Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis
Junya Zhai, Yacong Bo, Yan Lu, Chunli Liu, Lishi Zhang
PLoS One. 2017; 12(1): e0170172. Published online 2017 Jan 26. doi: 10.1371/journal.pone.0170172

(2) Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial
Bor-Jen Lee, Yu-Fen Tseng, Chi-Hua Yen, Ping-Ting Lin
Nutr J. 2013; 12: 142. Published online 2013 Nov 6. doi: 10.1186/1475-2891-12-142

(3) Lee BJ, Lin YC, Huang YC, Ko YW, Hsia S, Lin PT. The relationship between coenzyme Q10 and oxidative stress, antioxidant enzymes activities and coronary artery disease. ScientificWorldJournal. 2012;2012:792756.

(4) LC/MS/MS analysis of α-tocopherol and coenzyme Q₁₀ content in lyophilized royal jelly, beebread and drone homogenate.
Hryniewicka M, Karpinska A, Kijewska M, Turkowicz MJ, Karpinska J.
J Mass Spectrom. 2016 Nov;51(11):1023-1029. doi: 10.1002/jms.3821.

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