Acetyl hexapeptide-8 is a topical hexapeptide that inhibits the SNAP25 component (a protein) of another family of proteins, the SNARE. Being injectable, the concern was to investigate any significant adverse events. In a double-blind, placebo-controlled study, no adverse events were reported (1).
Pre-occupancy is that peptides in creams marketed as anti-aging can penetrate the deep layers of the skin and potentially stimulate biological activity. This other study did not detect peptide under the skin (2).
