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Scutellaria Baicalensis (Scullcap) Root Powder
Rating : 7
| Evaluation | N. Experts | Evaluation | N. Experts |
|---|---|---|---|
| 1 | 6 | ||
| 2 | 7 | ||
| 3 | 8 | ||
| 4 | 9 | ||
| 5 | 10 |
0 pts from Al222
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 | "Descrizione" about Scutellaria Baicalensis (Scullcap) Root Powder by Al222 (23433 pt) | 2025-Jan-14 19:01 |  |
| Read the full Tiiip | (Send your comment) |
Scutellaria Baicalensis Root Powder is derived from the roots of Scutellaria baicalensis, a plant known for its medicinal properties and long use in traditional herbal medicine. This powder is valued for its antioxidant, anti-inflammatory, and antimicrobial properties, making it an ideal ingredient in cosmetics to soothe irritated skin, protect against environmental damage, and promote skin health. It is particularly effective for sensitive, aging, and acne-prone skin.
Chemical Composition and Structure
Scutellaria Baicalensis Root Powder contains several bioactive compounds, including:
- Flavonoids: Baicalin, baicalein, and wogonin, which provide potent antioxidant, anti-inflammatory, and anti-aging effects.
- Triterpenoids: Contribute to the anti-inflammatory and skin-soothing properties of the extract.
- Phenolic Acids: Help provide protective and rejuvenating effects on the skin.
- Polysaccharides: Support hydration and reinforce the skin barrier.
Physical Properties
- Appearance: Fine powder, light yellow or amber in color.
- Odor: Herbal, slightly bitter.
- Solubility: Insoluble in water but may be used in combination with other ingredients in formulations.
- Stability: Stable under neutral to slightly acidic pH conditions; sensitive to light and heat.
Production Process
- Harvesting: The roots of Scutellaria baicalensis are harvested during the plant's optimal growth period to ensure the highest concentration of bioactive compounds.
- Drying and Grinding: The plant material is dried and then finely ground into powder form.
- Filtration and Purification: The powder is purified to remove impurities, ensuring a high-quality product.
- Standardization: The final powder is standardized to ensure consistent levels of key bioactives, such as flavonoids and triterpenoids.
Applications
Medical Applications
- Anti-inflammatory Treatments: Used in traditional remedies to reduce swelling and irritation.
- Antimicrobial Action: Helps prevent infections and promote skin healing.
- Antioxidant Protection: Protects the skin from oxidative stress, supporting the skin’s natural defenses against aging.
Cosmetics
- Soothing and Calming: Reduces redness and discomfort in sensitive or irritated skin.
- Anti-aging: Helps combat signs of aging by reducing oxidative stress and stimulating collagen production.
- Antioxidant Protection: Shields the skin from environmental aggressors and oxidative damage, promoting a youthful appearance.
- Hydration: Enhances moisture retention and strengthens the skin’s protective barrier.
CAS 94279-99-9 EC number 304-845-9
Industrial Applications
- Used in natural and organic skincare products for its antioxidant, anti-inflammatory, and antimicrobial properties.
- Found in masks, toners, serums, and creams targeting aging, acne, and sensitive skin concerns.
Environmental and Safety Considerations
- Biodegradability: As a natural plant-derived extract, it is biodegradable and environmentally friendly.
- Safety Profile: Safe for cosmetic use within regulated concentrations. As with all plant-based ingredients, individuals with sensitivities to Lamiaceae family plants should use caution.
- Sustainability: Cultivated and harvested responsibly to minimize environmental impact.
References__________________________________________________________________________
Chmiel M, Stompor-Gorący M. Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases. Int J Mol Sci. 2023 Mar 1;24(5):4732. doi: 10.3390/ijms24054732.
Abstract. Plant roots, due to a high content of natural antioxidants for many years, have been used in herbal medicine. It has been documented that the extract of Baikal skullcap (Scutellaria baicalensis) has hepatoprotective, calming, antiallergic, and anti-inflammatory properties. Flavonoid compounds found in the extract, including baicalein, have strong antiradical activity, which improves overall health and increases feelings of well-being. Plant-derived bioactive compounds with antioxidant activity have for a long time been used as an alternative source of medicines to treat oxidative stress-related diseases. In this review, we summarized the latest reports on one of the most important aglycones with respect to the pharmacological activity and high content in Baikal skullcap, which is 5,6,7-trihydroxyflavone (baicalein).
Wen Y, Wang Y, Zhao C, Zhao B, Wang J. The Pharmacological Efficacy of Baicalin in Inflammatory Diseases. Int J Mol Sci. 2023 May 26;24(11):9317. doi: 10.3390/ijms24119317.
Abstract. Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity and lipophilicity limit the bioavailability and pharmacological functions. Therefore, an in-depth study of baicalin's bioavailability and pharmacokinetics contributes to laying the theoretical foundation for applied research in disease treatment. In this view, the physicochemical properties and anti-inflammatory activity of baicalin are summarized in terms of bioavailability, drug interaction, and inflammatory conditions.
Yu P, Li J, Luo Y, Sun J, Hu Y, Lin B, Meng X, Xiang L. Mechanistic Role of Scutellaria baicalensis Georgi in Breast Cancer Therapy. Am J Chin Med. 2023;51(2):279-308. doi: 10.1142/S0192415X23500155.
Abstract. Breast cancer is one of the most common malignancies in women, and exhibits high metastasis, recurrence and fatality rates. Novel therapies for breast cancer are constantly emerging, such as targeted therapy, oncolytic virotherapy, and immunotherapy. Despite their potential, these new therapies are still in their infancy, and chemotherapy remains the standard treatment for breast cancer. Therefore, it is of great significance to develop safe and efficient treatment drugs or adjuvants for breast cancer treatment. Traditional Chinese medicine (TCM) has a long clinical history in China, in which Scutellaria baicalensis Georgi exhibits favorable antibreast cancer activities. We therefore conducted a systematic review of the available literature to better understand the molecular mechanisms of S. baicalensis in breast cancer treatment. S. baicalensis and its active components (baicalein, baicalin, wogonin, wogonoside, oroxylin A and scutellarin) exhibited promising antibreast cancer activity through proliferation inhibition, apoptosis induction, invasion and metastasis blockading, and drug-resistance and non-coding RNA regulation. Additionally, senescence, autophagy, angiogenesis, and glycolysis mechanisms were observed to play a role in their antibreast cancer activity. Furthermore, multiple signaling pathways contributed to the antitumor effects of S. baicalensi, such as the NF-[Formula: see text]B, Wnt/[Formula: see text]-catenin, SATB1, Bcl2 family proteins, Caspase, PI3K/Akt, mTOR, ERK, p38-MAPK, TGF-[Formula: see text]/Smad, and Hippo/YAP pathways. This review provides valuable insights into the role of S. baicalensis as a breast cancer treatment and acts as a foundation for further investigations in this field.
Wu TH, Lin TY, Yang PM, Li WT, Yeh CT, Pan TL. Scutellaria baicalensis Induces Cell Apoptosis and Elicits Mesenchymal-Epithelial Transition to Alleviate Metastatic Hepatocellular Carcinoma via Modulating HSP90β. Int J Mol Sci. 2024 Mar 6;25(5):3073. doi: 10.3390/ijms25053073.
Abstract. Hepatocellular carcinoma is one of the most common malignant tumors in the world and shows strong metastatic potential. Current medicine for hepatocellular carcinoma therapy is invalid, while Scutellaria baicalensis Georgi exhibits the pharmaceutical potential to treat liver diseases and liver cancer. Herein, we verified the inhibitory properties and the pivotal molecules regimented by Scutellaria baicalensis on advanced hepatocellular carcinoma. At first, the viability of SK-Hep-1 cells was significantly reduced under treatment of Scutellaria baicalensis extract in a dose-dependent manner without affecting the growth of normal hepatocyte. Scutellaria baicalensis extract application could remarkably cause apoptosis of SK-Hep-1 cells through p53/cytochrome C/poly-ADP ribose polymerase cascades and arrest the cell cycle at the G1/S phase by downregulating cyclin-dependent kinases. Meanwhile, administration of Scutellaria baicalensis extract remarkably attenuated the migration capability as well as suppressed matrix metalloproteinase activity of advanced hepatocellular carcinoma cells. The proteome profiles and network analysis particularly implied that exposure to Scutellaria baicalensis extract downregulated the expression of HSP90β, and the clinical stage of hepatocellular carcinoma is also positively correlated with the HSP90β level. Combined treatment of Scutellaria baicalensis extract and HSP90β siRNAs could markedly enhance the ubiquitination activity and the degradation of vimentin to subsequently inhibit the metastatic property of SK-Hep-1 cells. Moreover, application of Scutellaria baicalensis extract and HSP90β siRNAs depleted phosphorylation of AKT, which stimulated the expression of p53 and consecutively triggered cell apoptosis. These findings suggest that HSP90β may be a prospective target for the effective therapy of advanced hepatocellular carcinoma via accelerating apoptosis of hepatocellular carcinoma cells and eliciting mesenchymal-epithelial transition with the administration of Scutellaria baicalensis extract.
Jo HG, Baek CY, Song HS, Lee D. Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis. Int J Mol Sci. 2024 Feb 9;25(4):2127. doi: 10.3390/ijms25042127.
Abstract. Osteoarthritis is the most common type of arthritis, characterized by joint pain and a decline in physiological function. Scutellaria baicalensis Georgi (SB) is potentially effective against osteoarthritis because of its wide range of anti-inflammatory pharmacological activities. This study aimed to identify the mode of action of SB against osteoarthritis using network pharmacology prediction and experimental verification. Networks were constructed to key compounds, hub targets, and pathways essential for SB's effectiveness against osteoarthritis. Additionally, in vivo and in vitro tests were performed, including investigations on weight bearing in hind limbs, the acetic acid-induced writhing response, lipopolysaccharide-stimulated RAW264.7 cells, and serum cytokine responses. We identified 15 active compounds and 14 hub targets, supporting the anti-osteoarthritis effects of SB. The Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that fluid shear stress, atherosclerosis, phosphatidylinositol 3-kinase-Akt signaling, and cellular senescence pathways were important. SB showed substantial anti-inflammatory, analgesic, and joint tissue-protective effects against osteoarthritis. Our study shows that SB has the potential value to be further investigated as a candidate material for the treatment of osteoarthritis in the future.
Wang PW, Lin TY, Yang PM, Fang JY, Li WT, Pan TL. Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage. Biomed Pharmacother. 2022 Nov;155:113798. doi: 10.1016/j.biopha.2022.113798.
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| "Descrizione" about Scutellaria Baicalensis (Scullcap) Root Powder by Al222 (23433 pt) | 2025-Jan-14 18:59 | |
| Read the full Tiiip | (Send your comment) |
Scutellaria Baicalensis Root Powder è ricavata dalla radice della pianta Scutellaria baicalensis, conosciuta per le sue proprietà medicinali e il suo utilizzo nella medicina tradizionale. Questa polvere è apprezzata per le sue proprietà antiossidanti, anti-infiammatorie e antimicrobiche, un ingrediente ideale nei cosmetici per lenire la pelle irritata, proteggere dai danni ambientali e promuovere la salute della pelle. È efficace per pelli sensibili, mature e inclini ad acne.
Composizione Chimica e Struttura
La polvere di radice di Scutellaria Baicalensis contiene vari composti bioattivi, tra cui:
- Flavonoidi: Baicalina, baicaleina e wogonina, che offrono potenti effetti antiossidanti, anti-infiammatori e anti-invecchiamento.
- Triterpenoidi: Contribuiscono alle proprietà anti-infiammatorie e lenitive dell'estratto.
- Acidi Fenolici: Aiutano a conferire gli effetti protettivi e rigeneranti sulla pelle.
- Polisaccaridi: Supportano l’idratazione e rinforzano la barriera cutanea.
Proprietà Fisiche
- Aspetto: Polvere fine di colore giallo chiaro o ambrato.
- Odore: Erbaceo, leggermente amaro.
- Solubilità: Insolubile in acqua, ma può essere utilizzata in combinazione con altri ingredienti nelle formulazioni.
- Stabilità: Stabile in condizioni di pH neutro o leggermente acido; sensibile alla luce e al calore.
Processo di Produzione
- Raccolta: Le radici di Scutellaria baicalensis vengono raccolte durante il periodo di crescita ottimale della pianta per garantire un massimo contenuto di composti bioattivi.
- Essiccazione e Macinatura: Il materiale vegetale viene essiccato e successivamente finemente macinato per ottenere la polvere.
- Filtrazione e Purificazione: La polvere viene purificata per rimuovere le impurità, garantendo un prodotto di alta qualità.
- Standardizzazione: La polvere finale viene standardizzata per garantire livelli costanti di bioattivi chiave, come flavonoidi e triterpenoidi.
Applicazioni
Applicazioni Mediche
- Trattamenti Anti-infiammatori: Utilizzata nei rimedi tradizionali per ridurre gonfiori e irritazioni.
- Azione Antimicrobica: Aiuta a prevenire infezioni e a favorire la guarigione delle ferite cutanee.
- Protezione Antiossidante: Protegge la pelle dallo stress ossidativo, supportando le difese naturali contro l'invecchiamento.
Cosmetici
- Lenitiva e Calmanante: Riduce il rossore e il disagio nelle pelli sensibili o irritate.
- Anti-invecchiamento: Aiuta a contrastare i segni dell'invecchiamento riducendo lo stress ossidativo e stimolando la produzione di collagene.
- Protezione Antiossidante: Protegge la pelle dagli aggressori ambientali e dai danni ossidativi, favorendo un aspetto giovane.
- Idratazione: Migliora la ritenzione dell'umidità e rinforza la barriera protettiva della pelle.
CAS 94279-99-9 EC number 304-845-9
Applicazioni Industriali
- Utilizzata in prodotti per la cura della pelle naturali e biologici per le sue proprietà antiossidanti, anti-infiammatorie e antimicrobiche.
- Presente in maschere, tonici, sieri e creme destinati a trattare i problemi legati all'invecchiamento, all'acne e alla pelle sensibile.
Considerazioni Ambientali e di Sicurezza
- Biodegradabilità: Essendo un estratto naturale derivato dalla pianta, è biodegradabile e rispettoso dell'ambiente.
- Profilo di Sicurezza: Sicura per l'uso cosmetico nelle concentrazioni regolate. Come con tutti gli ingredienti di origine vegetale, le persone sensibili a piante della famiglia delle Lamiaceae dovrebbero usare cautela.
- Sostenibilità: Coltivata e raccolta in modo responsabile per ridurre l'impatto ambientale.
References__________________________________________________________________________
Chmiel M, Stompor-Gorący M. Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases. Int J Mol Sci. 2023 Mar 1;24(5):4732. doi: 10.3390/ijms24054732.
Abstract. Plant roots, due to a high content of natural antioxidants for many years, have been used in herbal medicine. It has been documented that the extract of Baikal skullcap (Scutellaria baicalensis) has hepatoprotective, calming, antiallergic, and anti-inflammatory properties. Flavonoid compounds found in the extract, including baicalein, have strong antiradical activity, which improves overall health and increases feelings of well-being. Plant-derived bioactive compounds with antioxidant activity have for a long time been used as an alternative source of medicines to treat oxidative stress-related diseases. In this review, we summarized the latest reports on one of the most important aglycones with respect to the pharmacological activity and high content in Baikal skullcap, which is 5,6,7-trihydroxyflavone (baicalein).
Wen Y, Wang Y, Zhao C, Zhao B, Wang J. The Pharmacological Efficacy of Baicalin in Inflammatory Diseases. Int J Mol Sci. 2023 May 26;24(11):9317. doi: 10.3390/ijms24119317.
Abstract. Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity and lipophilicity limit the bioavailability and pharmacological functions. Therefore, an in-depth study of baicalin's bioavailability and pharmacokinetics contributes to laying the theoretical foundation for applied research in disease treatment. In this view, the physicochemical properties and anti-inflammatory activity of baicalin are summarized in terms of bioavailability, drug interaction, and inflammatory conditions.
Yu P, Li J, Luo Y, Sun J, Hu Y, Lin B, Meng X, Xiang L. Mechanistic Role of Scutellaria baicalensis Georgi in Breast Cancer Therapy. Am J Chin Med. 2023;51(2):279-308. doi: 10.1142/S0192415X23500155.
Abstract. Breast cancer is one of the most common malignancies in women, and exhibits high metastasis, recurrence and fatality rates. Novel therapies for breast cancer are constantly emerging, such as targeted therapy, oncolytic virotherapy, and immunotherapy. Despite their potential, these new therapies are still in their infancy, and chemotherapy remains the standard treatment for breast cancer. Therefore, it is of great significance to develop safe and efficient treatment drugs or adjuvants for breast cancer treatment. Traditional Chinese medicine (TCM) has a long clinical history in China, in which Scutellaria baicalensis Georgi exhibits favorable antibreast cancer activities. We therefore conducted a systematic review of the available literature to better understand the molecular mechanisms of S. baicalensis in breast cancer treatment. S. baicalensis and its active components (baicalein, baicalin, wogonin, wogonoside, oroxylin A and scutellarin) exhibited promising antibreast cancer activity through proliferation inhibition, apoptosis induction, invasion and metastasis blockading, and drug-resistance and non-coding RNA regulation. Additionally, senescence, autophagy, angiogenesis, and glycolysis mechanisms were observed to play a role in their antibreast cancer activity. Furthermore, multiple signaling pathways contributed to the antitumor effects of S. baicalensi, such as the NF-[Formula: see text]B, Wnt/[Formula: see text]-catenin, SATB1, Bcl2 family proteins, Caspase, PI3K/Akt, mTOR, ERK, p38-MAPK, TGF-[Formula: see text]/Smad, and Hippo/YAP pathways. This review provides valuable insights into the role of S. baicalensis as a breast cancer treatment and acts as a foundation for further investigations in this field.
Wu TH, Lin TY, Yang PM, Li WT, Yeh CT, Pan TL. Scutellaria baicalensis Induces Cell Apoptosis and Elicits Mesenchymal-Epithelial Transition to Alleviate Metastatic Hepatocellular Carcinoma via Modulating HSP90β. Int J Mol Sci. 2024 Mar 6;25(5):3073. doi: 10.3390/ijms25053073.
Abstract. Hepatocellular carcinoma is one of the most common malignant tumors in the world and shows strong metastatic potential. Current medicine for hepatocellular carcinoma therapy is invalid, while Scutellaria baicalensis Georgi exhibits the pharmaceutical potential to treat liver diseases and liver cancer. Herein, we verified the inhibitory properties and the pivotal molecules regimented by Scutellaria baicalensis on advanced hepatocellular carcinoma. At first, the viability of SK-Hep-1 cells was significantly reduced under treatment of Scutellaria baicalensis extract in a dose-dependent manner without affecting the growth of normal hepatocyte. Scutellaria baicalensis extract application could remarkably cause apoptosis of SK-Hep-1 cells through p53/cytochrome C/poly-ADP ribose polymerase cascades and arrest the cell cycle at the G1/S phase by downregulating cyclin-dependent kinases. Meanwhile, administration of Scutellaria baicalensis extract remarkably attenuated the migration capability as well as suppressed matrix metalloproteinase activity of advanced hepatocellular carcinoma cells. The proteome profiles and network analysis particularly implied that exposure to Scutellaria baicalensis extract downregulated the expression of HSP90β, and the clinical stage of hepatocellular carcinoma is also positively correlated with the HSP90β level. Combined treatment of Scutellaria baicalensis extract and HSP90β siRNAs could markedly enhance the ubiquitination activity and the degradation of vimentin to subsequently inhibit the metastatic property of SK-Hep-1 cells. Moreover, application of Scutellaria baicalensis extract and HSP90β siRNAs depleted phosphorylation of AKT, which stimulated the expression of p53 and consecutively triggered cell apoptosis. These findings suggest that HSP90β may be a prospective target for the effective therapy of advanced hepatocellular carcinoma via accelerating apoptosis of hepatocellular carcinoma cells and eliciting mesenchymal-epithelial transition with the administration of Scutellaria baicalensis extract.
Jo HG, Baek CY, Song HS, Lee D. Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis. Int J Mol Sci. 2024 Feb 9;25(4):2127. doi: 10.3390/ijms25042127.
Abstract. Osteoarthritis is the most common type of arthritis, characterized by joint pain and a decline in physiological function. Scutellaria baicalensis Georgi (SB) is potentially effective against osteoarthritis because of its wide range of anti-inflammatory pharmacological activities. This study aimed to identify the mode of action of SB against osteoarthritis using network pharmacology prediction and experimental verification. Networks were constructed to key compounds, hub targets, and pathways essential for SB's effectiveness against osteoarthritis. Additionally, in vivo and in vitro tests were performed, including investigations on weight bearing in hind limbs, the acetic acid-induced writhing response, lipopolysaccharide-stimulated RAW264.7 cells, and serum cytokine responses. We identified 15 active compounds and 14 hub targets, supporting the anti-osteoarthritis effects of SB. The Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that fluid shear stress, atherosclerosis, phosphatidylinositol 3-kinase-Akt signaling, and cellular senescence pathways were important. SB showed substantial anti-inflammatory, analgesic, and joint tissue-protective effects against osteoarthritis. Our study shows that SB has the potential value to be further investigated as a candidate material for the treatment of osteoarthritis in the future.
Wang PW, Lin TY, Yang PM, Fang JY, Li WT, Pan TL. Therapeutic efficacy of Scutellaria baicalensis Georgi against psoriasis-like lesions via regulating the responses of keratinocyte and macrophage. Biomed Pharmacother. 2022 Nov;155:113798. doi: 10.1016/j.biopha.2022.113798.
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Component type: Natural Main substances: Last update: 2025-01-14 18:28:19 | Chemical Risk: |
