Palmitoyl Tripeptide-38 is a synthetic peptide used in skincare products for its potential anti-aging and skin-rejuvenating properties. It is formed through the reaction of palmitic acid with Tripeptide-38, where palmitic acid is conjugated to the peptide to enhance its stability and efficacy in topical applications.

Chemical Composition and Structure

Palmitoyl Tripeptide-38 consists of:

Tripeptide Sequence: A chain of three amino acids that make up Tripeptide-38, chosen for their specific biological activities.
Palmitoyl Group: A fatty acid chain (palmitic acid) attached to the peptide via a chemical bond, which enhances the peptide’s ability to penetrate the skin and adhere to skin cells.
Peptide Bond: The bond formed between palmitic acid and Tripeptide-38, which stabilizes the peptide and extends its activity.

Physical Properties

Palmitoyl Tripeptide-38 is characterized by:

Appearance: Typically a white or off-white powder, or it can be in solution depending on the formulation.
Solubility: Soluble in both water and oil due to the palmitoyl modification, facilitating its integration into various cosmetic formulations.
Stability: The palmitoyl modification contributes to the peptide's stability and prolonged effectiveness in cosmetic products.

Production Process

The production process for Palmitoyl Tripeptide-38 includes:

Reaction: Palmitic acid is reacted with Tripeptide-38 to create Palmitoyl Tripeptide-38. This reaction involves attaching the fatty acid to the peptide through a chemical bond.
Purification: The product is purified to remove any residual reagents or impurities, ensuring high purity and effectiveness.
Formulation: The purified Palmitoyl Tripeptide-38 is incorporated into skincare products, such as serums and creams, during the formulation process.
Quality Control: The final product undergoes rigorous testing for purity, potency, and stability to ensure it meets safety and efficacy standards.

Applications

Medical: Palmitoyl Tripeptide-38 is primarily used in cosmetic applications rather than medical ones, with its benefits focused on improving skin health and appearance.
Cosmetic: Used in anti-aging products to stimulate collagen production, improve skin elasticity, and reduce the appearance of wrinkles and fine lines. It is commonly found in facial serums, moisturizers, and creams.
Other: Occasionally used in other personal care products aimed at enhancing skin texture and reducing signs of aging.

Environmental and Safety Considerations

Palmitoyl Tripeptide-38 is considered safe for use in cosmetic formulations when applied according to guidelines. The production process is managed to minimize environmental impact, and the final product is subjected to strict quality controls to ensure safety and efficacy. Proper disposal and handling practices are followed to maintain environmental safety.

INCI


Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.
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