Thiamine Hydrochloride
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![]() | "Descrizione" about Thiamine Hydrochloride by Al222 (21074 pt) | 2024-Mar-28 08:05 | ![]() |
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Thiamine Hydrochloride, also known as Vitamin B1 Hydrochloride, is a water-soluble vitamin that plays a crucial role in energy metabolism and nervous system function. It is the hydrochloride salt form of thiamine (Vitamin B1) and is commonly used in dietary supplements, food fortification, and medical treatments due to its stability and solubility.
The name describes the structure of the molecule:
Chemical Industrial Synthesis Process
Industrially it appears in the form of a white powder, is soluble in water and is characterised by a sharp odour.
It is found in bran, cereal products, potatoes, rice and vegetables.
What it is used for and where
Cosmetics INCI Functions
Fragrance. It plays a very important role in the formulation of cosmetic products as it allows perfume to be enhanced, masked or added to the final product, improving its commercial viability. The consumer always expects to find a pleasant scent in a cosmetic product.
Skin conditioning agent - Miscellaneous. This ingredient has the task of modifying the condition of the skin when it is damaged or dry by reducing its flakiness and restoring its elasticity.
Medical
It has the function of burning sugar. Those who use sugar and alcohol excessively suffer from a deficiency of this vitamin (1).
Many studies have focused on the possibility of its metabolic benefits on diabetes mellitus (2).
It is used to treat a disease of the nerve endings called Beri Beri.
Benefits:
The most relevant studies on this vitamin have been selected with a summary of their contents:
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Synonyms:
References_____________________________________________________________________
(1) Sutherland GT, Sheedy D, Kril JJ. Neuropathology of alcoholism. Handb Clin Neurol. 2014;125:603-15. doi: 10.1016/B978-0-444-62619-6.00035-5.
(2) Al-Attas O, Al-Daghri N, Alokail M, Abd-Alrahman S, Vinodson B, Sabico S. Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2.
Clin Med Insights Endocrinol Diabetes. 2014 Jan 23;7:1-6. doi: 10.4137/CMED.S13573. eCollection 2014.
Abstract. Thiamine deficiency has been documented to be prevalent in patients with diabetes mellitus, and correction of thiamine deficiency in this population may provide beneficial effects in several cardiometabolic parameters, including prevention of impending complications secondary to chronic hyperglycemia. In this interventional study, we aim to determine whether thiamine supplementation is associated with cardiometabolic improvements in patients with diabetes mellitus type 2 (DMT2). A total of 86 subjects (60 DMT2 and 26 age- and BMI-matched controls) were included and were given thiamine supplements (100 mg/day) for six months. Anthropometrics and metabolic profiles were measured routinely. Serum thiamine and its derivatives were measured using high performance liquid chromatography. In all groups, there was a significant decrease in total cholesterol after three months (p = 0.03) as well as in HDL cholesterol after six months of thiamine supplementation (p = 0.009). Significant improvements were also observed in the mean serum levels of creatinine (p = 0.001), as well as thiamine and its derivatives in both serum and urinary levels across follow-up visits (p-values 0.002 and <0.001, respectively). In the DMT2 group, improvements were observed in lipid profile (mean serum LDL and total cholesterol with p-values 0.008 and 0.006, respectively), serum thiamine (p < 0.001), TMP (p < 0.001), TDP (p < 0.001), urinary thiamine (p < 0.001) and serum creatinine (p < 0.001). Thiamine supplementation is a promising adjuvant therapy for patients with DMT2. Longer clinical trials are needed to determine its protective effect in DMT2 complications.
Nacitarhan C, Minareci E, Sadan G. The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes. Exp Clin Endocrinol Diabetes. 2014 Mar;122(3):173-8. doi: 10.1055/s-0033-1363977.
Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial.
Eur J Nutr. 2013 Oct;52(7):1821-4. doi: 10.1007/s00394-013-0534-6.
Abstract. Purpose: To assess the effect of high-dose oral thiamine supplements on glucose tolerance in patients with impaired glucose metabolism.Methods: Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, where all participants received both placebo and thiamine capsules (3 × 100 mg/day) for 6 weeks in a cross-over manner. The main endpoint was changes in 2-h plasma glucose. Fasting plasma glucose and insulin, 2-h plasma insulin, the hemostatic model assessment of insulin resistance (HOMA-IR), renal function measurement and thiamin status were also evaluated at the commencement and completion of each treatment period.....Conclusion/interpretation: Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation.
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Component type: Chemical Main substances: Last update: 2024-03-28 07:29:50 | Chemical Risk: |