Propane-1,2-diol esters of fatty acids is a chemical compound, obtained by the esterification reaction of 1,2-propanediol with food fatty acids (palm, coconut, tallow).
What it is used for and where
Food
Ingredient on the European food additives list as E477, emulsifier.
Sicurezza
The EFSA Panel on Food Additives and Flavourings (FAF) onsidered that E 477 did not raise a concern for genotoxicity. No chronic toxicity, carcinogenicity, reproductive and developmental toxicity studies with propane-1,2-diol esters of fatty acids were available to the Panel. The Panel considered that any potential adverse effect of propane-1,2-diol ester of fatty acids would be due to propane-1,2-diol, previously re-evaluated as a food additive and for which an ADI of 25 mg/kg bw per day was established. Considering the overall metabolic and toxicity database, the Panel confirmed the previously established ADI for propane-1,2-diol esters of fatty acids (E 477) of 25 mg/kg bw per day expressed as propane 1,2 diol. This corresponds to an ADI for E 477 of 80 mg/kg bw per day, based on the concentration of free and bound propane-1,2-diol amounting to a maximum of 31% as laid down in the EU specification. The Panel concluded that there would not be a safety concern at the reported use levels for E 477 because exposure estimates from the refined non-brand loyal scenario did not exceed the ADI for E 477 in any of the population groups. However, the Panel aims to explore the feasibility of establishing a group ADI for those food additives that result in an exposure to propane-1,2-diol, such as E 477, E 1520 and E 405. Additionally, the Panel will also consider performing a combined exposure assessment to propane-1,2-diol resulting from the use of these food additives. The Panel also recommended some modifications of the EU specifications for E 477. (1).
References_____________________________________________________________________
(1) EFSA Panel on Food Additives and Flavourings (FAF), Younes, M., Aquilina, G., Castle, L., Engel, K.H., Fowler, P., Frutos Fernandez, M.J., Fürst, P., Gürtler, R., Gundert‐Remy, U. and Husøy, T., 2018. Re‐evaluation of propane‐1, 2‐diol esters of fatty acids (E 477) as a food additive. EFSA Journal, 16(12), p.e05497.