Hydrolyzed mangifera indica juice extract is the product obtained from the plant of the same name and is derived from the juice of mangoes through a hydrolysis process, which breaks down the juice into smaller, more bioavailable components. This extract is used in various cosmetic and skincare products for its beneficial properties, including moisturizing, soothing, and antioxidant effects.

Chemical Composition and Structure: Hydrolyzed Mango Juice Extract contains:

Vitamins: Rich in vitamins such as Vitamin C and Vitamin E, which provide antioxidant benefits and support skin health.

Sugars: Includes natural sugars that help in hydration and maintaining skin moisture levels.

Amino Acids: Contains amino acids that are essential for skin repair and regeneration.

Polyphenols: Rich in polyphenols, which offer antioxidant and anti-inflammatory benefits.

Minerals: Provides essential minerals like potassium and magnesium that contribute to skin hydration and overall health.

The hydrolysis process breaks down the larger molecules in mango juice into smaller fragments, making them easier for the skin to absorb and utilize.

Physical Properties:

• Color: Typically varies from light yellow to amber, depending on the concentration and processing method.
• Consistency: Usually appears as a liquid or gel-like substance, depending on the formulation and concentration.
• Odor: Has a mild, fruity aroma characteristic of mangoes.
• Solubility: Soluble in water and compatible with a wide range of cosmetic formulations.

Production Process:

1. Harvesting: Mangoes are collected when fully ripe.
2. Juicing: The mangoes are processed to extract the juice.
3. Hydrolysis: The juice undergoes hydrolysis to break down the complex molecules into smaller, more effective components.
4. Purification: The hydrolyzed extract is filtered and purified to remove impurities and concentrate the active ingredients.
5. Preservation: The extract is stored under controlled conditions to maintain its quality and efficacy.

Applications:

• Cosmetics: Used in serums, lotions, creams, and masks for its hydrating, soothing, and antioxidant properties. It helps improve skin texture and provide moisture.

INCI Functions:

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS: 90063-86-8

EC number 290-045-4

• Hair Care: Incorporated into shampoos and conditioners for its nourishing and moisturizing effects on hair.
• Skin Care: Utilized in various skincare products for its soothing, anti-inflammatory, and rejuvenating benefits.

Environmental and Safety Considerations:

• Sustainability: Sustainable practices should be employed in the cultivation and processing of mangoes to minimize environmental impact.
• Allergies: Generally regarded as safe for topical application. However, like all extracts, it should be used in accordance with established guidelines to minimize the risk of allergic reactions or skin irritations. Individuals with allergies or very sensitive skin should use caution.
• Storage: The extract should be stored in cool, dry conditions to maintain its quality and prevent degradation.

Studies

Main cultivars: Carrie, Keitt, Glenn, Manzanillo, Maya, Rosa, Osteen, Tommy Atkins and Kensington Pride
Main vitamins and minerals n 100 grams:

• Potassium, 100 mg
• Phosphorus, 11 mg
• Calcium, 10 mg
• Magnesium, 9 mg
• Choline, 7.5 mg
• Vitamin A, 760 IU
• Vitamin C, 27 mg

It also has a good content of carotenoids (Neoxanthin, beta carotene) that have antioxidant activity.

Tannin and vanillin are present with 20% each, while gallic acid, coumarin, caffeic acid, ferroic acid and cinnamic acid are present in low percentages (1).

Mango peel extract demonstrated anti-tumor efficacy on cell lines of colon cancer by influencing cell viability and  inhibited the colony formation trend  (2).

An extract is obtained from the mango leaves that has demonstrated antibacterial activity against Staphylococcus aureus, a Gram-positive bacterium responsible for biofilm formation and infections (3).

Mango oil derived from the kernel has lower free fatty acids, carotenoid content, and peroxide value, and is usually used without any processing, which is otherwise mandatory for commercial vegetable oils. Palmitic, stearic and oleic acids are the main fatty acids, and the triglyceride composition and fatty acid profile suggest a wide range of trans free options (4).

Mango studies

References________________________________________________________________________

(1) Sharma, D., Gupta, S., Kumar, R., Singh, P., Singh, A., & Khan, H. (2024). An ethnopharmacological, phytochemical and pharmacological review on Mangifera indica (Mango). Research Journal of Pharmacology and Pharmacodynamics, 16(1), 30-34.

Abstract. Traditional medicine is a body of knowledge, skills, and practices based on traditional cultures' presumptions, beliefs, and experiences in order to maintain their health. Traditional herbal treatments are highly valued among many rural or indigenous people in many underdeveloped nations. According to the World Health Organization, about 80% of the world's population relies on traditional medicine, with 60% of rural Indians using herbal treatments. During the previous five years, utilization of herbal supplements grew from 2.5 % to 12 percent. Mangifera indica, a plant that is frequently used in ayurvedic medicine. Although there have already been literature reviews on this plant, this one is presented to gather all the most recent data on its pharmacological and phytochemical activities, which have been widely studied using a variety of techniques. Mango is said to have antidiabetic, anti-oxidant, antiviral, cardiotonic, hypotensive, and anti-inflammatory properties, according to studies. Numerous effects have also been investigated, including hypolipidemia, antimicrobial, hepatoprotective, and gastroprotective properties. Other effects include antibacterial, antifungal, anthelmintic, antiparasitic, antitumor, anti-HIV, anti-bone demineralization, antispasmodic, antipyretic, antidiarrheal, and immunomodulatory properties. These studies are extremely positive and suggest that additional research on this herb is needed to confirm these findings and elucidate additional potential therapeutic effects. The use of mango in clinical trials for a range of ailments is also recommended.

(2) Lauricella M, Lo Galbo V, Cernigliaro C, Maggio A, Palumbo Piccionello A, Calvaruso G, Carlisi D, Emanuele S, Giuliano M, D'Anneo A. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells. Antioxidants (Basel). 2019 Sep 22;8(10):422. doi: 10.3390/antiox8100422. PMID: 31546694; PMCID: PMC6826946.

Abstract. Ethanolic extracts from Mangifera indica L. have been proved to possess anti-tumor properties in many cancer systems. However, although most effects have been demonstrated with fruit pulp extract, the underlying molecular mechanisms of mango peel are still unclear. This study was designed to explore the effects of mango peel extract (MPE) on colon cancer cell lines. MPE affected cell viability and inhibited the colony formation trend of tumor cells, while no effects were observed in human dermal fibroblasts used as a non-cancerous cell line model. These events were a consequence of the induction of apoptosis associated to reactive oxygen species (ROS) production, activation of players of the oxidative response such as JNK and ERK1/2, and the increase in Nrf2 and manganese superoxide dismutase (MnSOD). Significantly, mango peel-activated stress triggered a DNA damage response evidenced by the precocious phosphorylation of histone 2AX (γH2AX), as well as phosphorylated Ataxia telangiectasia-mutated (ATM) kinase and p53 upregulation. Mango peel extract was also characterized, and HPLC/MS (High Performance Liquid Chromatography/Mass Spectrometry) analysis unveiled the presence of some phenolic compounds that could be responsible for the anti-cancer effects. Collectively, these findings point out the importance of the genotoxic stress signaling pathway mediated by γH2AX in targeting colon tumor cells to apoptosis.

(3) Manzur AG, Sm Junior V, Morais-Costa F, Mariano EG, Careli RT, da Silva LM, Coelho SG, de Almeida AC, Duarte ER. Extract of Mangifera indica L. leaves may reduce biofilms of Staphylococcus spp. in stainless steel and teatcup rubbers. Food Sci Technol Int. 2020 Jan;26(1):11-20. doi: 10.1177/1082013219858529. 

Abstract. Human ingestion of antimicrobial residues in dairy products is a problem of public health. In this study we evaluated antibacterial effectiveness of aqueous and ethanolic leaf extracts of Mangifera indica L. as a natural alternative for reduction of Staphylococcus spp. biofilms. Eight Staphylococcus spp. strains from cows with mastitis and the Staphylococcus aureus strain (ATCC 25923) were evaluated. High performance liquid chromatography indicated the presence of phenolic compounds in the aqueous extract. Agilent Technologies gas chromatography revealed the presence of phenolic compounds, carbohydrates, and gallic acid in ethanolic extract. The tannin contents were 2.27 ± 0.01 and 2.67 ± 0.01% for ethanolic extract and aqueous extract, respectively. Extracts were evaluated in agar diffusion test and the size of inhibition zones were compared. The ethanolic extract was the most effective, showing minimum inhibitory concentrations and minimum bactericidal concentrations between 1.8-7.5 and 15.1-45.3 mg/ml, respectively. After tannin removal, the extracts were less effective, indicating these secondary metabolites as one of the main antibacterial compounds. The ethanolic extract at 45.3 mg/ml reduced mature biofilms in teat rubber (average: 3.91 log reduction) and stainless steel (average: 3.87 log reduction) after 5 min of contact. The extracts of M. indica leaves represent natural alternatives against Staphylococcus spp. strains and the ethanolic extract shows potential as a natural sanitizer.

(4) Nadeem M, Imran M, Khalique A. Promising features of mango (Mangifera indica L.) kernel oil: a review. J Food Sci Technol. 2016 May;53(5):2185-95. doi: 10.1007/s13197-015-2166-8. Epub 2016 Apr 29. PMID: 27407184; PMCID: PMC4921070. 

Abstract. Mango kernel contains about 15 % good quality edible oil, that is comparable to soybean and cottonseed, which contain about 18-20 % oil. Mango kernel oil (MKO) has lower free fatty acids, carotenoid content and peroxide value, and is usually used without any processing, which is otherwise mandatory for commercial vegetable oils. Palmitic, stearic and oleic acids are the major fatty acids, triglyceride composition and fatty acid profile suggest wide range of trans free options. With 32-36 °C melting point, MKO is solid at room temperature, thus, does not require partial hydrogenation for application in foods. MKO can be used as an alternative of cocoa butter, which is used in chocolates and confectionaries. Total phenolic contents and induction period of MKO is greater than many commercial vegetable oils; thus, it can be used as an alternative of synthetic antioxidants for the preservation of fats and oils. Mangiferin, chlorogenic acid, quercetin and caffeic acid are the major phenolic compounds present in MKO. Functional properties of MKO can be further improved through fractionation, transesterification and interesterification for increased industrial applications.