2-Oleamido-1,3-Octadecanediol is a chemical compound, an oleic acid derivative, a lipid molecule belonging to the specific species of ceramides, the main constituents of the human skin's defence barrier and lipids in the stratum corneum where it has the ability to form stable lamellar structures.
2-Oleamido-1,3-Octadecanediol is a fatty acid-derived compound that acts as a skin-conditioning agent and emulsifier in cosmetic formulations. This compound is recognized for its emollient properties, helping to enhance skin texture and hydration. Due to its ability to form stable emulsions, it is commonly used in lotions, creams, and hair care products. Additionally, 2-Oleamido-1,3-Octadecanediol contributes to the overall stability and performance of cosmetic products.
Chemical Composition and Structure
2-Oleamido-1,3-Octadecanediol consists of:
- Oleamide: A long-chain fatty acid amide derived from oleic acid, known for its emollient and skin-conditioning properties.
- Octadecanediol: A diol with a long hydrocarbon chain that enhances the emulsifying properties of the compound.
The structure features a hydrophilic head from the diol and a hydrophobic tail from the oleamide, allowing it to effectively stabilize oil-in-water emulsions and improve the sensory experience of cosmetic products.
Physical Properties
Appearance: Typically a white to light yellow solid or semi-solid at room temperature.
Solubility: Soluble in oils and organic solvents; has limited solubility in water.
pH: Generally neutral, around 6-7, depending on the formulation.
Odor: Mild, characteristic of fatty acid derivatives.
Stability: Stable under normal storage conditions; should be kept away from extreme temperatures and light.
Production Process
Synthesis: 2-Oleamido-1,3-Octadecanediol is synthesized through the reaction of oleic acid with a suitable amine under controlled conditions, followed by the introduction of the diol component.
Purification: The resulting compound undergoes purification to remove any unreacted materials and by-products, ensuring a high-quality ingredient.
Formulation: Purified 2-Oleamido-1,3-Octadecanediol is incorporated into various cosmetic formulations to enhance texture and stability.
Applications
Medical: Limited use in topical formulations requiring moisturizing or emollient properties.
Cosmetics: Commonly found in creams, lotions, and hair conditioners for its emulsifying and skin-conditioning benefits.
INCI Functions:
Hair conditioning agent. A large number of ingredients with specific purposes can co-exist in a hair shampoo: cleansers, conditioners, thickeners, mattifying agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersing agents that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioners includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners.
Skin conditioning agent - Miscellaneous. This ingredient has the task of modifying the condition of the skin when it is damaged or dry by reducing its flakiness and restoring its elasticity.
Environmental and Safety Considerations
2-Oleamido-1,3-Octadecanediol is generally regarded as safe for use in cosmetics when applied according to recommended guidelines.
It is well-tolerated by most skin types, including sensitive skin.
Responsible sourcing and formulation practices are essential to ensure that the ingredient is free from harmful contaminants and produced sustainably.
References__________________________________________________________________________
Bährle-Rapp, M., & Bährle-Rapp, M. (2007). 2-Oleamido-1, 3-Octadecanediol. Springer Lexikon Kosmetik und Körperpflege, 386-386.
Dal Belo, Susi Elaine, et al. "Efficacy of a multitargeted, salicylic acid‐based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: results from a randomized study." Journal of Cosmetic Dermatology 23.3 (2024): 891-897.
Abstract. Introduction. Acne vulgaris (acne) is characterized by both inflammatory and non-inflammatory lesions. Benzoyl peroxide (BPO) 5% is approved to treat acne but may cause skin irritation and/or contact allergy.. Objectives. To compare the benefit in acne of a multitargeted dermocosmetic cream containing salicylic acid, lipohydroxy acid, niacinamide, 2-oleamido-1,3-octadecanediol, piroctone olamine, zinc, Aqua posae filiformis, and thermal spring water (DC-Eff) to BPO 5% gel....Conclusions. DC-Eff applied twice daily is as beneficial as BPO in improving mild-to-moderate acne. DC-Eff was better tolerated than BPO and highly appreciated.
Luengo, G. S., Galliano, A., & Dubief, C. (2014). Aqueous lubrication in cosmetics. World Scientific Publishing Co Pte Ltd.: Singapore, 103-144.
2-Oleamido-1,3-Octadecanediol 
