Palmitamide MEA: what it is, cosmetic uses, safety and alternatives

Palmitamide MEA (Palmitoylethanolamide) is a chemical compound, ethanolamide of palmitic acid. Ethanolamides consist of carboxylic acid and amides.

Palmitamide MEA is a fatty acid amide derived from palmitic acid and monoethanolamine (MEA). It is primarily used in cosmetic and personal care products for its emollient, conditioning, and thickening properties. Palmitamide MEA is commonly found in shampoos, conditioners, lotions, and creams, where it helps improve the texture of the product and provides hydration and softness to the skin and hair.

Chemical Composition and Structure

Palmitamide MEA is an amide formed by the reaction between palmitic acid, a long-chain saturated fatty acid, and monoethanolamine. This chemical structure enables Palmitoyl ethanolamide to form a protective film on the skin or hair, helping to retain moisture and enhance the smoothness and softness of the skin and hair.

Physical Properties

It typically appears as a white or yellowish waxy solid, soluble in oils and partially soluble in water. Palmitoyl ethanolamide is stable and can be used in a wide range of cosmetic formulations due to its emollient and thickening properties.

Production Process

Palmitamide MEA (Palmitoyl ethanolamide) is produced through a condensation reaction between palmitic acid and monoethanolamine, followed by a purification process to obtain a stable and safe product for cosmetic use.

The name describes the structure of the molecule:

• Palmitamide refers to an amide derived from palmitic acid, a common saturated fatty acid. An amide is a functional group consisting of a carbonyl group (C=O) linked to a nitrogen atom (N).
• MEA (2-aminoethanol) or Monoethanolamine belongs to the first generation of ethanolamines, is a primary amine and is a strongly alkaline agent, corrosion inhibitor and chemical intermediate.

Description and function of the raw materials used in production

• Palmitic acid - A saturated fatty acid commonly found in fats and oils.
• Monoethanolamine (MEA) - An organic molecule used to produce amides and other compounds.

The synthesis process takes place in different steps:

• Production of palmitic acid from natural sources such as palm oil or animal fats. It can also be produced synthetically.
• Conversion. Palmitic acid is converted to palmitamide through a reaction with ammonia.
• Reaction with monoethanolamine. Palmitamide undergoes a reaction process with monoethanolamine to form palmitamide MEA.
• Purification.  The final product is purified to remove any unreacted materials and by-products from the reaction mixture to obtain pure Palmitamide MEA.

Safety 

MEA should not be included in products formulated as aerosols and in products containing N-nitroso. Scientific literature agrees that MEA can penetrate and absorb into the skin and cause skin irritation, particularly on the scalp.

What it is used for and where

Cosmetics

Antistatic agent. Static electricity build-up has a direct influence on products and causes electrostatic adsorption. The antistatic ingredient reduces static build-up and surface resistivity on the surface of the skin and hair.

Surfactant - Foam booster. Its function is to introduce gas bubbles into the water for a purely aesthetic factor, which does not affect the cleaning process, but only satisfies the commercial aspect of the detergent by helping to spread the detergent on the hair. This helps in the commercial success of a shampoo formulation. Since sebum has an inhibiting action on the bubble, more foam is produced in the second shampoo.

Viscosity Enhancing Agent - aqueous. Since viscosity is important for increasing the chemical and physical stability of the product, Viscosity Enhancing Agent acqueous is an important dosage factor in gels, suspensions, emulsions, solutions. Increasing viscosity makes formulations less sedimentary and more homogeneously thickened.

Alternatives

• Molecular Formula   C₁₈H₃₇NO₂  
• CAS  544-31-0
• UNII    6R8T1UDM3V
• EC Number    208-867-9

References__________________________________________________________________________

Belsito, M., Hill, R. A., Klaassen, C. D., Liebler, D., Marks Jr, J. G., & Ronald, C. (2012). On the Safety Assessment of Ethanolamides as Used in Cosmetics. Final Amended Report.

The CIR Expert Panel concluded that the ethanolamides listed below are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed. 

Corazza, M., Minghetti, S., Bianchi, A., Virgili, A., & Borghi, A. (2014). Barrier creams: facts and controversies. Dermatitis, 25(6), 327-333.

Abstract. Barrier creams (BCs) represent devices aiming to protect the skin from contact with exogenous hazardous substances, especially under working conditions. By preventing penetration and absorption of contaminants, BCs are designed to reduce the risk of developing both irritant and allergic contact dermatitis. In fact, BCs should improve stratum corneum hydration as well as provide emolliency to maintain skin integrity and to restore and repair the epidermis barrier function. The formulation and ingredients of the available BCs vary widely, and thus the choice of a BC should depend on the kind of contaminants, occupational conditions, and skin dysfunction. Although BCs are commonly recommended to prevent occupational contact dermatitis, their real benefit remains controversial. The aims of this review are to help the choice of appropriate BCs and to analyze the actual effectiveness in maintaining an intact skin barrier, preventing contact dermatitis, and speeding up the healing of barrier-impaired skin.....Palmitoyl ethanolamide (palmitamide MEA) is another lipidic active ingredient that decreases itching.