Laurus nobilis leaf extract controls inflammation by suppressing NLRP3 inflammasome activation.
Lee EH, Shin JH, Kim SS, Lee H, Yang SR, Seo SR.
J Cell Physiol. 2019 May;234(5):6854-6864. doi: 10.1002/jcp.27434

The effect of Laurus nobilis L. essential oil and different packaging systems on the photo-oxidative stability of Chemlal extra-virgin olive oil.
Taoudiat A, Djenane D, Ferhat Z, Spigno G.
J Food Sci Technol. 2018 Oct;55(10):4212-4222. doi: 10.1007/s13197-018-3357-x.

Effect of chitosan edible coating with Laurus nobilis extract on shelf life of cashew.
Azimzadeh B, Jahadi M.
Food Sci Nutr. 2018 Mar 23;6(4):871-877. doi: 10.1002/fsn3.630

Bioactive compounds from bay leaves (Laurus nobilis) extracted by microwave technology.
Muñiz-Márquez DB, Wong-Paz JE, Contreras-Esquivel JC, Rodríguez-Herrera R, Aguilar CN.
Z Naturforsch C. 2018 Sep 25;73(9-10):401-407. doi: 10.1515/znc-2018-0009.

Proton-independent activation of acid-sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis.
Osmakov DI, Koshelev SG, Andreev YA, Dubinnyi MA, Kublitski VS, Efremov RG, Sobolevsky AI, Kozlov SA.
Br J Pharmacol. 2018 Mar;175(6):924-937. doi: 10.1111/bph.14134.

Antibacterial and Antioxidant Activities of Essential Oils from Artemisia herba-alba Asso., Pelargonium capitatum × radens and Laurus nobilis L.
Rafiq R, Hayek SA, Anyanwu U, Hardy BI, Giddings VL, Ibrahim SA, Tahergorabi R, Kang HW.
Foods. 2016 Apr 11;5(2). pii: E28. doi: 10.3390/foods5020028.

The effect of Laurus nobilis on the blood and lenses antioxidant activity in rabbit under fat-enriched diet.
Casamassima D, Chiosi F, Vizzarri F, Palazzo M, Costagliola C.
Physiol Res. 2017 May 4;66(2):325-333.

Laurus nobilis, Zingiber officinale and Anethum graveolens Essential Oils: Composition, Antioxidant and Antibacterial Activities against Bacteria Isolated from Fish and Shellfish.
Snuossi M, Trabelsi N, Ben Taleb S, Dehmeni A, Flamini G, De Feo V.
Molecules. 2016 Oct 22;21(10). pii: E1414.

Bay laurel (Laurus nobilis) as potential antiviral treatment in naturally BQCV infected honeybees.
Aurori AC, Bobiş O, Dezmirean DS, Mărghitaş LA, Erler S.
Virus Res. 2016 Aug 15;222:29-33. doi: 10.1016/j.virusres.2016.05.024

Bay laurel (Laurus nobilis L.)

The term bay laurel refers to Laurus nobilis L., an evergreen shrub or small tree typical of warm temperate and Mediterranean climates, cultivated and naturalised in many countries of the Mediterranean area and introduced into other mild–climate regions. It prefers well-drained soils, from moderately fertile to calcareous, with good light exposure and low tolerance to waterlogging. The plant generally has a bushy or small–tree habit, with erect stems and a dense crown; the leaves are persistent, leathery, lanceolate, with entire margins and a glossy surface, and they are characterised by a typical balsamic–spicy aroma due to their volatile fraction. The flowers are small and yellowish, grouped in axillary umbels; the fruits are ovoid drupes that turn black–violet when ripe.

From a commercial standpoint, the main harvested organ is the leaf, used fresh or, more commonly, dried as an aromatic drug and spice for preparing savoury dishes, preserves, and stocks. Leaves may be marketed whole, crushed, or as part of aromatic blends; in industrial and artisanal contexts, extracts and essential oil obtained by steam distillation are also used. The quality of the raw material is influenced by factors such as origin, harvest time, drying conditions (temperature, air flow), and storage conditions (protection from light, excess humidity, and contamination).

The composition of bay laurel includes a significant fraction of essential oil (usually a few percent or less on a dry basis), a portion of fixed oil (lipids), carbohydrates, fibre, small amounts of proteins, minerals, and phenolic compounds. The essential oil is characterised by the presence of monoterpenes and their oxygenated derivatives (including 1,8–cineole, eugenol, linalool and other components that vary according to ecotype), which determine the typical aromatic profile. The leaves also contain tannins, flavonoids, and other secondary metabolites that contribute to their technological and sensory properties. The yield and composition of the essential oil are affected by pedoclimatic conditions, leaf maturity, and post–harvest handling.

From an application perspective, bay laurel is widely used in the food chain as a spice and aromatic plant, particularly in slow–cooked dishes, marinades, preserves, and meat- and legume–based products. It is also used for the production of infusions and extracts intended for herbal preparations and, to a lesser extent, cosmetic applications (traditional soaps, hygiene products, and formulations based on aromatic extracts). The quality and suitability for use depend on controlling compositional parameters (essential oil content, residual moisture, absence of contaminants) and on compliance with good manufacturing practices throughout processing and packaging.

Botanical classification (APG IV)

• Botanical name: Laurus nobilis L.

• Common name: bay laurel, sweet bay, laurel

• Family: Lauraceae

• Order: Laurales

Modern clades (phylogenetic):

• Angiosperms

• Magnoliids

• Domain: Eukaryota

• Kingdom: Plantae

Cultivation and growth conditions

Climate

Bay laurel is characteristic of Mediterranean climates, with mild, relatively wet winters and warm, dry summers. It tolerates brief cold spells, but severe or prolonged frost can damage leaves, buds, and young shoots. It performs best in coastal or temperate hilly areas with moderate air humidity and limited thermal extremes.

Exposure

The plant prefers full sun or bright partial shade. In full sun, foliage is typically denser and more aromatic; in shade, shoots may elongate more and aromatic intensity can be reduced. Sheltered positions, protected from strong, drying winds, help limit leaf scorch and branch breakage.

Soil

Bay laurel is fairly adaptable but grows best in soils that are:

• Well drained, without persistent waterlogging;

• Of loam or loam-sandy texture;

• With a slightly acidic to neutral pH (approx. 6.0–7.5).

Heavy, compacted, or constantly wet soils increase the risk of root rot and slow overall development. A good level of organic matter improves structure, water-holding capacity, and general vigour.

Irrigation

Water requirements are moderate:

• In typical Mediterranean conditions, established plants can often be grown with minimal or no irrigation.

• Young plants and container-grown specimens, however, need regular watering, especially in summer.

The goal is to keep the soil slightly moist, not saturated. Periods of complete drying-out in containers should be avoided, while sustained waterlogging must also be prevented.

Temperature

Bay laurel grows well with average temperatures between about 15 and 28 °C.

• Short dips below 0 °C may be tolerated by established plants, but

• Temperatures below about –6/–8 °C can cause leaf burn, dieback of shoots, or death of exposed parts.

In very hot, dry summers, growth may slow if root-zone moisture is inadequate.

Fertilization

Fertility management focuses mainly on:

• Organic matter (compost, well-rotted manure) to maintain soil structure and gradual nutrient release;

• Nitrogen (N) in moderate amounts, to support vegetative growth without causing excessively soft, disease-prone tissues;

• Phosphorus (P) to sustain root system efficiency and regrowth;

• Potassium (K) to improve hardiness, tissue robustness, and overall foliage quality.

Fertilization should be adjusted according to soil analysis, plant age, and production goals (ornamental use, leaf harvest, hedging, etc.).

Crop care

• Pruning:

  • Generally light but regular, to maintain a balanced, compact canopy, favour air circulation, and control plant size.

  • Removal of dead, diseased, or damaged branches is essential for plant health.

  • More substantial pruning can be used to rejuvenate old plants or to maintain formal hedges and topiary shapes.

• Weed management:

  • Especially important in the establishment phase, when young plants compete poorly with vigorous weeds.

  • Organic mulches (bark, compost, straw) help suppress weeds, conserve moisture, and improve soil structure over time.

• Plant health:

  • Bay laurel is generally robust, but in very humid conditions leaf spots, bacterial problems, or root rots may occur.

  • Good drainage, adequate spacing, and balanced nutrition are key preventive tools.

Harvest

Leaves can be harvested throughout the year, preferably from mature, healthy shoots away from sources of contamination. For technical or herbal uses, fully developed, undamaged leaves are selected. They are usually dried in thin layers in a well-ventilated, shaded place to preserve colour and aromatic quality.

Pruning cuts and hedge trimmings often provide additional material that can be sorted and used for leaf harvest.

Propagation

Bay laurel is propagated mainly by:

• Semi-hardwood or hardwood cuttings:

  • Taken in summer or early autumn from healthy, well-ripened shoots;

  • Rooted in light, well-drained substrates under controlled humidity.

• Suckers / division:

  • Where basal shoots are present, they can be separated and replanted.

• Seed:

  • Used less frequently because germination is slow and variable and offspring may not be uniform;

  • Mainly of interest for breeding or diversity conservation.

Vegetative propagation (cuttings, selected suckers) ensures greater uniformity in morphology, aroma, and growth habit.

Indicative nutritional values per 100 g (dried leaves)
Energy: approx. 300–330 kcal
Protein: approx. 6–8 g
Total carbohydrates: approx. 45–48 g
Dietary fibre: approx. 25–26 g
Total fat: approx. 8 g

• SFA

• MUFA

• PUFA
  Minerals: calcium, iron, magnesium, potassium
  Vitamins: vitamin A (as carotenoids), some B-group vitamins
  Sodium: low

(These values refer to 100 g dried leaves; typical culinary use is only a few grams or less per recipe.)

Key constituents

• Essential oil components

  • 1,8-cineole (eucalyptol), α-pinene, β-pinene, linalool, geraniol, and other mono- and sesquiterpenes

• Polyphenols and tannins

  • flavonoids and other antioxidant compounds

• Macronutrients

  • mainly carbohydrates and dietary fibre, with modest amounts of proteins and lipids

• Micronutrients

  • minerals (calcium, iron, magnesium, potassium)

  • carotenoids (provitamin A) and some B-group vitamins

Production process

• Harvesting

  • collection of healthy, mature leaves from Laurus nobilis plants

• Drying

  • low-temperature drying, protected from direct light, to preserve essential oil composition and colour

• Selection and packing

  • removal of damaged material, grading and packing as whole or broken leaves

• Essential oil extraction

  • steam distillation of leaves to obtain Laurus Nobilis Leaf Oil, used in food flavourings and cosmetics

• Standardisation (for extracts)

  • possible adjustment of composition to meet analytical specifications (e.g. minimum cineole content)

Physical properties
Elongated, leathery, aromatic leaves
Green to olive-green colour in dried form
Essential oil: clear, highly volatile, strongly aromatic liquid
High fibre content in the dried leaf matrix

Sensory and technological properties
Intense, warm, balsamic and slightly woody aroma
Spicy, slightly bitter and resinous flavour
High aromatic yield at very low doses
Good aroma stability in whole leaves when correctly dried and stored
Suitable for use in long cooking times (soups, stews, braises) as flavour develops in fat–water systems

Food applications
Aromatisation of soups, broths, stews, sauces, meat, fish, legumes and vegetable dishes
Use in pickles and preserved products (e.g. marinades, brines)
Ingredient in herb blends and ready-made seasoning mixes

Use of bay essential oil (within legal flavouring limits) in processed foods and beverages

Laurel oil has been subject to restrictions and, in some cases, bans for use in certain cosmetic products within the European Union due to its content of methyleugenol, which is classified as a sensitizing allergen and raises potential safety concerns at specific exposure levels.

Nutrition & health
Very low caloric contribution at normal use levels
Presence of polyphenols and other antioxidant compounds with potential health interest
Aromatic molecules that may contribute to digestive comfort in traditional usage
Bay leaves are considered safe for culinary use at typical doses; the leaf is often removed before serving, so actual ingestion of leaf tissue is minimal
Fibre intake from bay is negligible in real consumption scenarios, but the leaf structure is highly fibrous

Portion note
Typical use is 1–3 leaves per recipe (pot, stew, sauce), depending on volume and desired flavour intensity.
Due to the strong aroma, higher doses are rarely necessary and may lead to excessive bitterness.

Allergens & intolerances
Bay leaf is not among the major regulated food allergens
Rare individual sensitivities to aromatic components are possible
Concentrated essential oil can be irritating to skin and mucosae at high doses or undiluted use
Potential cross-reactions should be considered only in highly sensitive individuals with broad spice intolerance

Storage & shelf-life
Fresh leaves: best stored refrigerated and used within a relatively short time
Dried leaves:

• store in closed containers, protected from light, heat and humidity

• shelf-life of months to years, with gradual loss of aroma
  Essential oil:

• store in dark glass bottles, tightly closed

• protect from heat and air to limit oxidation and composition changes

Safety & regulatory
Bay leaves as a culinary herb fall under general food safety and hygiene requirements, including HACCP-based systems
Raw material must meet limits for contaminants, pesticide residues and microbiological quality
Bay essential oil used as a food flavouring must comply with flavourings regulations, purity criteria and specific restrictions where applicable
Safe-use levels must be respected, especially for concentrated extracts and essential oils

Labelling
For bay leaf products and bay-flavoured foods, the label should indicate:

• ingredient name (e.g. bay leaves, dried bay leaf, natural flavouring)

• full ingredient list for food products

• net weight, lot number, best-before date

• origin, where required or claimed

• storage conditions

• clear indication of any allergens present from other ingredients

Troubleshooting
Weak aroma in finished dishes

• possible causes: old or poorly stored leaves, low quality raw material

• corrective actions: use fresher, whole leaves, adjust dosage, review storage conditions

Excess bitterness or overpowering flavour

• possible causes: too many leaves or very long contact time in small-volume dishes

• corrective actions: reduce dose, remove leaves earlier during cooking

Loss of aroma during storage

• causes: exposure to light, heat, air and moisture

• corrective actions: use airtight containers, store in a cool, dark place, rotate stock more frequently

Sustainability & supply chain
Bay laurel is a typical Mediterranean species; cultivation or managed wild harvesting should aim to protect plant stands and local ecosystems
The high aromatic yield means that relatively small quantities can flavour large volumes of food, limiting resource use
A traced and controlled supply chain (good agricultural practices, correct drying and storage) supports sustainable and consistent-quality production
Certifications and quality schemes can enhance transparency and market value

Main INCI functions (cosmetics)
From bay leaves and their processing, typical cosmetic ingredients include:

• Laurus Nobilis Leaf Oil

  • fragrance component (spicy, herbal, balsamic note)

  • potential antioxidant contribution in some formulations

• Laurus Nobilis Leaf Extract

  • botanical extract used for its aromatic, toning and possible antioxidant properties

In cosmetics, use levels and purity must comply with safety assessments and cosmetic regulations, particularly regarding sensitisation and irritation potential.

Conclusion

Bay laurel (Laurus nobilis) is a high-impact aromatic ingredient rich in essential oil, polyphenols and volatile terpenes. At typical culinary doses it has a minimal nutritional impact but a very significant sensory and technological role.
Proper drying, selection and storage allow preservation of its aromatic profile and functional properties for use in both food and cosmetic applications. Compliance with hygiene, safety and labelling requirements ensures reliability and quality along the entire supply chain.

Mini-glossary
SFA – saturated fatty acids; excessive replacement of other fats by SFA may be less favourable for blood lipid balance.
MUFA – monounsaturated fatty acids; generally considered beneficial when replacing part of SFA in the diet.
PUFA – polyunsaturated fatty acids; include omega-3 and omega-6, essential for various physiological processes.
HACCP – Hazard Analysis and Critical Control Points; structured system used to manage food safety risks in production and processing environments.

Bay laurel studies

References__________________________________________________________________________

Caputo L, Nazzaro F, Souza LF, Aliberti L, De Martino L, Fratianni F, Coppola R, De Feo V. Laurus nobilis: Composition of Essential Oil and Its Biological Activities. Molecules. 2017 Jun 3;22(6):930. doi: 10.3390/molecules22060930. 

Abstract. Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible oil effects on the Central Nervous System.

Paparella A, Nawade B, Shaltiel-Harpaz L, Ibdah M. A Review of the Botany, Volatile Composition, Biochemical and Molecular Aspects, and Traditional Uses of Laurus nobilis. Plants (Basel). 2022 Apr 29;11(9):1209. doi: 10.3390/plants11091209. 

Abstract. Laurus nobilis L. is an aromatic medicinal plant widely cultivated in many world regions. L. nobilis has been increasingly acknowledged over the years as it provides an essential contribution to the food and pharmaceutical industries and cultural integrity. The commercial value of this species derives from its essential oil, whose application might be extended to various industries. The chemical composition of the essential oil depends on environmental conditions, location, and season during which the plants are collected, drying methods, extraction, and analytical conditions. The characterization and chemotyping of L. nobilis essential oil are extremely important because the changes in composition can affect biological activities. Several aspects of the plant's secondary metabolism, particularly volatile production in L. nobilis, are still unknown. However, understanding the molecular basis of flavor and aroma production is not an easy task to accomplish. Nevertheless, the time-limited efforts for conservation and the unavailability of knowledge about genetic diversity are probably the major reasons for the lack of breeding programs in L. nobilis. The present review gathers the scientific evidence on the research carried out on Laurus nobilis L., considering its cultivation, volatile composition, biochemical and molecular aspects, and antioxidant and antimicrobial activities.

Pilipović K, Jurišić Grubešić R, Dolenec P, Kučić N, Juretić L, Mršić-Pelčić J. Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol. Antioxidants (Basel). 2023 Mar 18;12(3):746. doi: 10.3390/antiox12030746. 

Abstract. With the progress of medicine, especially in the last century, life expectancy increased considerably. As a result, age-related diseases also increased, especially malignancies and degenerative diseases of the central nervous system. The incidence and prevalence of neurodegenerative diseases steadily increased over the years, but despite efforts to uncover the pathophysiological processes behind these conditions, they remain elusive. Among the many theories, oxidative stress was proposed to be involved in neurodegenerative processes and to play an important role in the morbidity and progression of various neurodegenerative disorders. Accordingly, a number of studies discovered the potential of natural plant constituents to have significant antioxidant activity. This review focused on several plant-based antioxidants that showed promising results in the prevention and treatment of neurodegenerative diseases. Laurus nobilis, Aronia melanocarpa, and celastrol, a chemical compound isolated from the root extracts of Tripterygium wilfordii and T. regelii, are all known to be rich in antioxidant polyphenols.

Fantasma F, Samukha V, Aliberti M, Colarusso E, Chini MG, Saviano G, De Felice V, Lauro G, Casapullo A, Bifulco G, Iorizzi M. Essential Oils of Laurus nobilis L.: From Chemical Analysis to In Silico Investigation of Anti-Inflammatory Activity by Soluble Epoxide Hydrolase (sEH) Inhibition. Foods. 2024 Jul 20;13(14):2282. doi: 10.3390/foods13142282. 

Abstract. Laurus nobilis L. is commonly used in folk medicine in the form of infusion or decoction to treat gastrointestinal diseases and flatulence as a carminative, antiseptic, and anti-inflammatory agent. In this study, the essential oil (EO) composition of wild-grown L. nobilis L. leaves collected from seven different altitudinal locations in the Molise region and adjacent regions (Abruzzo and Campania) was investigated. EOs from the leaves were obtained by hydrodistillation and analyzed by GC-FID and GC/MS, and 78 compounds were identified. The major oil components were 1,8-cineol (43.52-31.31%), methyl-eugenol (14.96-4.07%), α-terpinyl acetate (13.00-8.51%), linalool (11.72-1.08%), sabinene (10.57-4.85%), α-pinene (7.41-3.61%), eugenol (4.12-1.97%), and terpinen-4-ol (2.33-1.25%). Chemometric techniques have been applied to compare the chemical composition. To shed light on the nutraceutical properties of the main hydrophobic secondary metabolites (≥1.0%) of laurel EOs, we assessed the in vitro antioxidant activities based on 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging activity and the reducing antioxidant power by using a ferric reducing power (FRAP) assay. Furthermore, we highlighted the anti-inflammatory effects of seven EOs able to interfere with the enzyme soluble epoxide hydrolase (sEH), a key enzyme in the arachidonic acid cascade, in concentrations ranging from 16.5 ± 4.3 to 8062.3 ± 580.9 mg/mL. Thanks to in silico studies, we investigated and rationalized the observed anti-inflammatory properties, ascribing the inhibitory activity toward the disclosed target to the most abundant volatile phytochemicals (≥1.0%) of seven EOs.

Fernández NJ, Damiani N, Podaza EA, Martucci JF, Fasce D, Quiroz F, Meretta PE, Quintana S, Eguaras MJ, Gende LB. Laurus nobilis L. Extracts against Paenibacillus larvae: Antimicrobial activity, antioxidant capacity, hygienic behavior and colony strength. Saudi J Biol Sci. 2019 Jul;26(5):906-912. doi: 10.1016/j.sjbs.2018.04.008. 

Abstract. The aim of this work was to compare the antimicrobial activity against Paenibacillus larvae and the antioxidant capacity of two Laurus nobilis L. extracts obtained by different extraction methods. The hydroalcoholic extract was moreover added as supplementary diet to bees in field conditions to test behavioural effects and colony strength. Both laurel extracts were subjected to different phytochemical analysis to identify their bioactive compounds. Antimicrobial activity was analyzed by the minimal inhibitory concentration (MIC) determination by means the agar dilution method. The hydroalcoholic extract (HE) was able to inhibit the bacterial growth of all P. larvae strains, with 580 µg/mL mean value. This better antibacterial activity in relation to the essential oil (EO) could be explained by the presence of some phenolic compounds, such as flavonoids, evidenced by characteristic bands resulting from the Fourier Transform Infrared Spectroscopy (FTIR) analysis. Antioxidant activities of the extracts were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging ability and ferric reducing antioxidant power (FRAP) assays. The HE showed the highest antioxidant activity as measured by DPPH, with IC50 values of 257 ± 12 μg/mL. The FRAP assay method showed that the HE was 3-fold more effective reducing agent than the EO. When the bee colonies were supplied with laurel HE in sugar paste an improvement in their general condition was noticed, although neither the hygienic behavior nor the proportions of the breeding cells varied statistically due to the treatment. In conclusion, the inhibition power against P. larvae attributable to the phenolic compounds, the antioxidant capacity of the HE, and the non-lethal effects on adult honey bees on field trials suggest the HE of laurel as a promising substance for control American foulbrood disease.