Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro.
Ribeiro DL, Machado ART, da Silva Machado C, Santos PWDS, Aissa AF, Barcelos GRM, Antunes LMG.
Toxicology. 2019 Apr 17;422:25-34. doi: 10.1016/j.tox.2019.04.010.
Review of Published Bitter Orange Extract and p-Synephrine Adverse Event Clinical Study Case Reports.
Stohs SJ, Ray SD.
J Diet Suppl. 2019 Mar 5:1-9. doi: 10.1080/19390211.2019.1577936.
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
Xu WW, Zheng CC, Huang YN, Chen WY, Yang QS, Ren JY, Wang YM, He QY, Liao HX, Li B.
J Agric Food Chem. 2018 Sep 5;66(35):9248-9258. doi: 10.1021/acs.jafc.8b04020
STEMI in a Young Male after Use of Synephrine-Containing Dietary Supplement.
Unnikrishnan D, Annam R, Jacob A, Thyagarajan B, Farrugia P.
Case Rep Cardiol. 2018 Apr 1;2018:7074104. doi: 10.1155/2018/7074104.
Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise.
Gutiérrez-Hellín J, Del Coso J.
Med Sci Sports Exerc. 2018 Sep;50(9):1899-1906. doi: 10.1249/MSS.0000000000001653.
Safety evaluation of p-synephrine following 15 days of oral administration to healthy subjects: A clinical study.
Shara M, Stohs SJ, Smadi MM.
Phytother Res. 2018 Jan;32(1):125-131. doi: 10.1002/ptr.5956.
Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study.
Ratamess NA, Bush JA, Stohs SJ, Ellis NL, Vought IT, O'Grady EA, Kuper JD, Hasan SB, Kang J, Faigenbaum AD.
Phytother Res. 2018 Jan;32(1):94-102. doi: 10.1002/ptr.5953.
Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine.
Stohs SJ.
Phytother Res. 2017 Oct;31(10):1463-1474. doi: 10.1002/ptr.5879. Epub 2017
Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks.
Bakhiya N, Ziegenhagen R, Hirsch-Ernst KI, Dusemund B, Richter K, Schultrich K, Pevny S, Schäfer B, Lampen A.
Mol Nutr Food Res. 2017 Jun;61(6). doi: 10.1002/mnfr.201601020
Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males.
Jung YP, Earnest CP, Koozehchian M, Cho M, Barringer N, Walker D, Rasmussen C, Greenwood M, Murano PS, Kreider RB.
J Int Soc Sports Nutr. 2017 Jan 3;14:1. doi: 10.1186/s12970-016-0158-3.
Risk assessment of synephrine in dietary supplements.
Bakhyia N, Dusemund B, Richter K, Lindtner O, Hirsch-Ernst KI, Schäfer B, Lampen A.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Mar;60(3):323-331. doi: 10.1007/s00103-016-2506-5.
Synephrine 
