Matrixyl® inserted in topical cream has significantly improved the penetration of the cream compared to a simple topical application (1).

Matrixyl® has been shown to stimulate the production of collagen by fibroblasts, in vitro (2) reducing facial wrinkles (3).

References________________________________

(1) Photopneumatic Technology in Acne Treatment and Skin Rejuvenation: Histological Assessment
Tokuya Omi
Laser Ther. 2012 Jul 3; 21(2): 113–123. doi: 10.5978/islsm.12-OR-07

(2) Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Jones R. R., Castelletto V., Connon C. J., Hamley I. W. Mol Pharm. 2013 Mar 4;10(3):1063-9. doi: 10.1021/mp300549d. Epub 2013 Feb 4.

(3) Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Lintner K., Peschard O. Int J Cosmet Sci. 2000 Jun;22(3):207-18. doi: 10.1046/j.1467-2494.2000.00010.x.

PalMitoyl Pentapeptide-4 is a peptide composed of 5 amino acids marketed and registered under the name Matrixyl® by the French company Sedema SAS. It is an anti-wrinkle for cosmetics.

PalMitoyl Pentapeptide-4 studies

Molecular Formula: C₃₉H₇₅N₇O₁₀

Molecular Weight: 802.068 g/mol

CAS: 214047-00-4

EC Number: 606-757-9

UNIII: KK181SM5JG

Synonyms:

• WSGCRSMLXFHGRM-DEVHWETNSA-N
• L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-
• Palmitoyl pentapeptide-3
• Palmitoyl-L-Lys-L-Thr-L-Thr-L-Lys-L-Ser-OH
• palmitoyl-L-lysyl-L-threonyl-L-threonyl-L-lysyl-L-serine
• Matrixyl Acetate (Palmitoy Pentapeptide)
• Matrixyl|||N-(1-Oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-L-serine