Bisabolol, a natural component is a commercially important aromatic chemical extracted from the Candeia plant (Vanillosmopsis erythropappa) (1).

It has anti-inflammatory properties.

"Bisabolol studies"

Molecular Formula: C₁₅H₂₆O

Molecular Weight: 222.372 g/mol

CAS: 515-69-5  23178-88-3  25428-43-7  23089-26-1

EC Number: 246-973-7 208-205-9

UNII: 105S6I733Z

FEMA Number: 4666

PubChem Substance ID 57647161

MDL number MFCD03412455

Synonyms:

• alpha-Bisabolol
• (+)-a-Bisabolol
• SCHEMBL24988
• (-)-a-Bisabolol
• (+)-(1'R,2R)-alpha-Bisabolol
• (+)-alpha-Bisabolol
• Camilol
• D-alpha-Bisabolol
• (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
• alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol
• 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)-
• .alpha.-Bisabolol

References__________________________

(1) An untargeted metabolomic approach in the chemotaxonomic assessment of two Salvia species as a potential source of α-bisabolol.
Sandasi M, Kamatou GP, Viljoen AM.
Phytochemistry. 2012 Dec;84:94-101. doi: 10.1016/j.phytochem.2012.08.009.

Bisabolol.
Fiume MM
Int J Toxicol. 2017 Sep/Oct;36(5_suppl2):24S-25S. doi: 10.1177/1091581817716644

α-bisabolol β-D-fucopyranoside as a potential modulator of β-amyloid peptide induced neurotoxicity: An in vitro &in silico study.
Jeyakumar M, Sathya S, Gandhi S, Tharra P, Suryanarayanan V, Singh SK, Baire B, Pandima Devi K.
Bioorg Chem. 2019 Apr 19;88:102935. doi: 10.1016/j.bioorg.2019.102935.

(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.
Melo LT, Panchalingam V, Cherkas P, Campos AR, Avivi-Arber L, Sessle BJ.
Life Sci. 2019 Apr 16. pii: S0024-3205(19)30288-7. doi: 10.1016/j.lfs.2019.04.032

Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway.
Wu S, Peng L, Sang H, Ping Li Q, Cheng S.
J BUON. 2018 Sep-Oct;23(5):1407-1412.

(-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice.
Fernandes MYD, Carmo MRSD, Fonteles AA, Neves JCS, Silva ATAD, Pereira JF, Ferreira EO, Lima NMR, Neves KRT, Andrade GM.
Eur J Pharmacol. 2019 Jan 5;842:270-280. doi: 10.1016/j.ejphar.2018.09.036. Epub 2018 Oct 1.

Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus.
Muñoz-Pérez VM, Ortiz MI, Ponce-Monter HA, Monter-Pérez V, Barragán-Ramírez G.
Korean J Physiol Pharmacol. 2018 Jul;22(4):391-398. doi: 10.4196/kjpp.2018.22.4.391. Epub 2018 Jun 25.

Clinical efficacy of new α-bisabolol mouthwashes in postoperative complications of maxillofacial surgeries: a randomized, controlled, triple-blind clinical trial.
Amora-Silva BF, Ribeiro SC, Vieira CL, Mendes FR, Vieira-Neto AE, Abdon APV, Costa FN, Campos AR.
Clin Oral Investig. 2019 Feb;23(2):577-584. doi: 10.1007/s00784-018-2464-4. Epub 2018 May 3.