Compendium of the most significant studies with reference to properties, intake, effects.

Neto, H., Novák, C., & Matos, J. (2009). Thermal analysis and compatibility studies of prednicarbate with excipients used in semi solid pharmaceutical form. Journal of thermal analysis and calorimetry, 97(1), 367-374.

Abstract. Differential Scanning Calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG) and infrared spectroscopy (IR) techniques were used to investigate the compatibility between prednicarbate and several excipients commonly used in semi solid pharmaceutical form.

A. Tai,R. Bianchini,J. Jachowicz Texture analysis of cosmetic/pharmaceutical raw materials and formulations 27 February 2014 https://doi.org/10.1111/ics.12125

Abstract. The purpose of this work was to quantify textural properties of cosmetic and pharmaceutical raw materials.

Buraczewska, I., Berne, B., Lindberg, M., Törmä, H., & Lodén, M. (2007). Changes in skin barrier function following long‐term treatment with moisturizers, a randomized controlled trial. British Journal of Dermatology, 156(3), 492-498.

Abstract. To investigate the impact of long-term treatment with moisturizers on the barrier function of normal skin, as measured by transepidermal water loss (TEWL) and susceptibility to an irritant, and to relate those effects to the composition of the designed experimental moisturizers.

Gregolin, M. T., Chiari, B. G., Ribeiro, H. M., & Isaac, V. L. B. (2010). Rheological characterization of hydrophylic gels. Journal of dispersion science and technology, 31(6), 820-825.

Abstract. Rheological characteristics of gels were studied, with the focus on their use as a cosmetic base. Some ideal characteristics can be predicted by the rheological characterization, such as the performance, with easy application and without dripping or forming lumps and bubbles.

‎Parco Seung-han. (2014). Effect of Rheological Properties on the Yield Value in an Aqueous Polymer solution system 110-110, ‎‎Abstract Book of Research Papers, Korean Society of Polymers‎‎.‎

Abstract. An aim of this study is to study the correlation between rheological properties and yield value in low viscosity polymer aqueous solution.

Lam, H. T., Zupančič, O., Laffleur, F., & Bernkop-Schnürch, A. (2021). Mucoadhesive properties of polyacrylates: Structure–Function relationship. International Journal of Adhesion and Adhesives, 107, 102857.

Abstract. The objective of this study was to evaluate and compare the mucoadhesive properties of ten commercially available polyacrylates including linear polyacrylic acid of 100 and 450 kDa (PAA 100 and 450), with allyl pentaerythritol, allyl sucrose and divinyl glycol cross-linked PAAs (PAA AP, PAA AS/AP, PAA DG) as well as hydrophobically modified cross-linked PAAs (PAA C10-30).

A Study on the Rheological Behavior of Detergents for Powders 2011 https://ir.cnu.edu.tw/handle/310902800/24484

Abstract. With the increase in living standards, there has been an increase in the variety of detergents available in the market today. It is not only demanded that these products be sanitary and safe, but that they should also be effective in improving the appearance of our skin. For years, manufacturers have added powders, which are able to exfoliate the stratum corneum, to have anti-aging effects, and to give an appearance of beauty. However, if the powders are not evenly dispersed within the detergent, the efficacy and the appearance of the product is affected. This paper examined the proper way to disperse powders effectively in the detergents.

Bährle-Rapp M. (2007) Acrylates/C10–30 Alkyl Acrylate Crosspolymer. In: Springer Lexikon Kosmetik und Körperpflege. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71095-0_155

C10-30 alkyl acrylate crosspolymer: properties, uses, pros, cons, safety

C10-30 alkyl acrylate crosspolymer is a chemical compound, a cross-linked copolymer.

It appears as a soft white powder, soluble in water in its raw form, but in cosmetics and personal care products it is usually included in a solution or emulsion. The properties of the final product may vary depending on the specific formulation.

C10-30 alkyl acrylate crosspolymer is a term used in the cosmetics industry to refer to a class of copolymers formed from various C10-30 alkyl acrylates (esters of acrylic acid), cross-linked with an allyl pentaerythritol ether or an allyl sucrose ether.

They are broken down as follows:

• C10-30 Alkyl Acrylates are acrylic acid esters with an alkyl group containing 10 to 30 carbon atoms. The specific alkyl group can vary, resulting in a range of different acrylates.
• Crosspolymer refers to polymer chains linked together, forming a three-dimensional network. This cross-linking process can improve the properties of the polymer, making it more resistant to chemicals, heat and mechanical stress.
• Allyl Ether of Pentaerythritol or Allyl Ether of Sucrose are the cross-linking agents used to form the cross-linked polymer. They react with acrylate monomers to link the polymer chains together.

Description of the raw materials used in its production:

• C10-30 Fatty Alcohols are alcohols derived from natural fats or synthesized industrially. These alcohols consist of carbon chains of varying lengths, ranging from C10 to C30.
• Alkyl Acrylates are compounds obtained from the reaction of acrylic acid with fatty alcohols. In the synthesis of C10-30 Alkyl Acrylate Crosspolymer, a mixture of alkyl acrylates derived from C10 to C30 fatty alcohols is used.

Industrial chemical synthesis step-by-step:

• Preparation of Alkyl Acrylates - Alkyl acrylates are prepared by reacting acrylic acid with C10-30 fatty alcohols. This reaction involves the bonding of the acrylates with the carbon chains of the alcohols, forming the desired alkyl acrylates.
• Polymerization - The alkyl acrylates are then subjected to a polymerization process to form C10-30 Alkyl Acrylate Crosspolymer. During polymerization, the alkyl acrylate units bond together through covalent linkages, forming a three-dimensional network.
• Purification - The polymer obtained from the polymerization is purified to remove any impurities and by-products. This can be done through filtration and washing processes.
• Drying and Packaging - The purified C10-30 Alkyl Acrylate Crosspolymer is dried to remove residual moisture and then packaged for distribution and use in the cosmetic industry.

What it is used for and where

Polymeric thickeners have been used in pharmaceutical and cosmetic products for decades. They are primarily rheological modifiers, which change the physical properties of a system and, in suspension components, the rate of migration.

C10-30 alkyl acrylate crosspolymer has an excellent electrolyte tolerance, which allows high surfactants to be stabilised and insoluble ingredients to be suspended.

Pharmaceuticals

The inclusion of C10-30 alkyl acrylate crosspolymer in pharmaceutical formulations makes oil-in-water emulsions of organic oils more stable where emulsion stability is a product quality priority. It has been observed that the inclusion of this chemical compound in pharmaceutical emulsions containing a limited number of additives influences and improves the droplet size distribution in oil/water emulsions (1). 

Cosmetics

• Emulsion stabiliser. Emulsions are thermodynamically unstable. Emulsion stabilisers improve the formation and stability of single and double emulsions. as well as their shelf-life. It should be noted that in the structure-function relationship, the molar mass of the ingredient used plays an important role.
• Film-forming agent. It produces, upon application, a very thin continuous film with an optimal balance of cohesion, adhesion and stickiness on skin, hair or nails to counteract or limit damage from external phenomena such as chemicals, UV rays and pollution.
• Viscosity control agent. It controls and adapts, Increasing or decreasing, viscosity to the required level for optimal chemical and physical stability of the product and dosage in gels, suspensions, emulsions, solutions. 

C10-30 alkyl acrylate crosspolymer is predominantly used as a thickener, co-thickener or polymeric emulsifier in facial and body cleansing cosmetics to improve viscosity at pH 5.5. The amount included in the formula is typically 0.2% w/w in emulsions It usually interacts with non-ionic surfactants (2).

Commercial applications

Gelling Agent. C10-30 Alkyl Acrylate Crosspolymer is used in cosmetics and skincare products to create a gel-like consistency.

Emulsion Stabilizer. Used in creams and lotions to help stabilize emulsions and prevent components from separating.

Viscosity Enhancer. Increases the viscosity of products like lotions, creams, and gels, making them thicker.

Film Former. Can form a thin film on the skin or hair, helping to lock in moisture.

Suspending Agent. Helps to suspend solid particles in liquid or semi-liquid products.

The most relevant studies on this chemical compound have been selected with a summary of their contents:

C10-30 alkyl acrylate crosspolymer studies

Typical optimal commercial product characteristics C10-30 alkyl acrylate crosspolymer

Synonyms:

• Acrylates/C10-30 alkyl acrylate cross polymer
• Acrylates/C10-30 alkyl acrylate crosspolymer

References____________________________________________________________________

(1) Kizeviciene E, Jonaitiene L, Peciura R. EVALUATION OF ACRYLATES/C10-30 ALKYL ACRYLATE CROSS- POLYMER MIXTURE EFFECTIVENESS ON O/W TYPE EMULSION FORMULATION. Acta Pol Pharm. 2017 May;74(3):937-943. PMID: 29513964. 

Abstract. Acrylates/C1O-30 alkyl acrylate cross-polymer mixtures were used in order to prepare stable and oil-in-water (o/w) pharmaceutical emulsions of organic oils. The resulting o/w pre-emulsions, prepared with different alkyl acrylate cross-polymers were unequally stable. We observed a synergistic effect when a polymer mixture was used and-the resulting pre-emulsions were more stable for significant duration. The observed effect is confirmed by, statistical analysis, the feature is remarkably important when we look for more stable pharmaceutical emulsions formed with less additives.

(2) Simovic S, Tamburic S, Milic-Askrabic J, Rajic D. An investigation into interactions between polyacrylic polymers and a non-ionic surfactant: an emulsion preformulation study. Int J Pharm. 1999 Jul 20;184(2):207-17. doi: 10.1016/s0378-5173(99)00097-6. 

Abstract. The aim of this study was to investigate possible interactions between a polymeric emulsifier and a non-ionic surfactant, with a view of achieving better understanding of emulsion stabilisation mechanisms. The polymeric emulsifier used was acrylates/C10-30 alkyl acrylate crosspolymer (Pemulen TR-2(R)), while Polyoxyethylene 20 sorbitan mono-oleate (Polysorbate 80) has been chosen as a model surfactant. Both materials were used within the concentration range relevant for their practical application. A 0.2%w/w aqueous dispersion of polymeric emulsifier, containing various amounts of surfactant (from 0.01 to 1.0% w/w) was used throughout the study. Interfacial aspects of the proposed polymer/surfactant interactions were analysed by means of surface tension measurements. Changes in the network structure of the test dispersions were quantified by continuous shear rheometry, supported by the texture analysis. To analyse the influence of hydrophobic alkyl groups present on the Pemulen TR-2(R) chains, an unmodified, hydrophilic polyacrylic acid polymer, Carbopol 934P(R), was assessed under the same conditions. The results obtained by both surface tension and rheological studies have revealed large differences in behaviour of the two polymers in the presence of the model surfactant. Pemulen TR-2(R) was shown to desorb the surfactant from the surface, within the whole concentration range studied. Furthermore, an increase in viscosity and texture profile parameters with increasing Polysorbate 80 concentration up to 0.3% w/w was evident in the case of Pemulen TR-2(R) dispersions. This was followed by a decrease in the gel network strength at higher surfactant concentrations. On the other hand, Carbopol 934P(R) has shown no signs of surfactant desorption and only small changes in the network structure with the increasing concentration of surfactant. It is shown in this study that an interaction between a polymeric emulsifier Pemulen TR-2(R) and a non-ionic surfactant Polysorbate 80 does occur in their aqueous dispersion, and that it is: (a) hydrophobic in nature; (b) concentration-dependent; and (c) has an impact on the rheological properties of dispersion.