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Al222
Al222 (25123 pt) 2025-Oct-22 15:36

Alpinia Galanga Rhizome Extract

Botanical source: rhizome of Alpinia galanga (family Zingiberaceae).
INCI name: Alpinia Galanga Rhizome Extract.
CAS #: 84625-26-3.
EC #: 283-399-6.
Primary cosmetic function: skin conditioning (conditioning agent).

Key constituents
Phenylpropanoids and diarylheptanoids (e.g., 1′-acetoxychavicol acetate), minor flavonoids, and phenolic acids.
Volatile co-constituents may include 1,8-cineole, bornyl acetate, camphor, methyl cinnamate, traces of eugenol; profiles vary by solvent and origin.

Production process
Plant material is washed, optionally peeled, dried, and milled.
Extraction is performed with water/EtOH, glycols/glycerol, or via SFE with supercritical CO₂; the extract is filtered, optionally low-temperature concentrated, standardized on markers, and quality-checked (GC–MS for volatiles; HPLC for non-volatiles).
Packing uses barrier containers under GMP/HACCP with defined CCPs.

Use levels and solubility
Typical use: 0.1–2.0% in leave-on or rinse-off formats, adjusted to formula and local rules.
Hydroalcoholic/glycolic grades disperse in aqueous phases with co-solvents; more lipophilic extracts require solubilizers or emulsification into the oil phase.

Stability and formulation notes
Protect from light, heat, and air to limit oxidation and color/odor shift.
Prefer addition at cool-down; consider antioxidants in oil-rich bases.
Check sensory impact in pale or lightly fragranced products.

Safety and regulatory
Patch-test the finished product.
Monitor potential fragrance allergens if the volatile fraction is significant.
Verify regional labeling and any category-specific restrictions before launch.

Storage and shelf life
Store tightly closed, cool, and dark, in low-permeability containers with minimal headspace.
Apply FIFO rotation.

Sustainability and supply chain
Good practices include heat-recovery in processing, recyclable packaging, and effluent management against BOD/COD targets.

Mini-glossary
INCI — International Nomenclature of Cosmetic Ingredients: standardized cosmetic labeling name.
CAS — Chemical Abstracts Service registry number: unique identifier for a substance.
EC — European Community number: EU substance inventory identifier.
EtOH — Ethanol: common hydroalcoholic co-solvent for extracts.
CO₂ — Carbon dioxide used as a supercritical solvent for selective extraction.
SFE — Supercritical fluid extraction: extraction using supercritical fluids (often CO₂).
GC–MS — Gas chromatography–mass spectrometry: analytical fingerprint for volatile composition.
HPLC — High-performance liquid chromatography: quantifies non-volatile markers in extracts.
GMP — Good manufacturing practice: hygiene and process controls for consistency and traceability.
HACCP — Hazard analysis and critical control points: preventive safety system with defined CCPs.
CCP — Critical control point: a step where control prevents, eliminates, or reduces a hazard.
FIFO — First in, first out: inventory rotation principle—use the oldest compliant lot first.
BOD/COD — Biochemical/chemical oxygen demand: indicators of organic load in effluents and environmental impact.

Greater galangal (Alpinia galanga)

Greater galangal is a rhizome of the Zingiberaceae family with a citrusy–camphoraceous aromatic profile accented by peppery and resinous notes. It is used fresh, dried, or ground throughout Southeast Asian cuisines (e.g., curry pastes and soups such as tom kha), and as a raw material for essential oils and extracts.

Caloric value (100 g)
Fresh rhizome: approximately 60–80 kcal/100 g.
Dried/ground: approximately 300–360 kcal/100 g (moisture dependent; contribution at flavoring doses is modest).

Key constituents
Total essential oil typically 0.4–1.5% in dried rhizome, featuring 1,8-cineole (eucalyptol), bornyl acetate, camphor, eugenol, α-pinene, methyl cinnamate, with traces of citral.
Characteristic phenylpropanoids/diarylheptanoids (notably 1′-acetoxychavicol acetate), plus minor flavonoids.
Nonvolatile matrix of starch, fibers, simple sugars, organic acids, and minerals (K, Mg).
Essential-oil identity and lot consistency are commonly checked by GC–MS.

Average composition (indicative, dried rhizome, per 100 g)
Moisture: ~8–12 g.
Total carbohydrate: ~55–70 g (starch predominant).
Dietary fiber: ~10–20 g.
Protein: ~5–9 g.
Fat: ~1–5 g.
Ash: ~4–6 g.
Typical aw: low in dried material; higher (perishable) when fresh.

Production process
Cultivation and harvest: Perennial stands in tropical climates; rhizomes harvested at ~8–12 months when aroma is developed.
Primary preparation: Washing, optional peeling, and controlled slicing.
Drying: Hot-air or assisted solar drying (≈45–60 °C) to a stable final moisture; managing RH and temperature limits volatile loss.
Milling and standardization: Grinding and sieving to specification; optional steam sterilization; volatile profile verification by GC–MS.
Extraction: Steam distillation for essential oil; hydroalcoholic extraction (EtOH) or SFE with supercritical CO₂ for selective extracts.
Packing: Moisture/oxygen-barrier packaging under GMP/HACCP with defined CCPs for hygiene, moisture, and foreign bodies.

Sensory and technological properties
Aroma and taste: Notes of pine/eucalyptus, citrus, gentle ginger-like warmth, and peppery spice; cleaner and more camphoraceous than ginger.
Functionality: Potent flavor at low dose; mild antioxidant–aromatic support in marinades and soups; good infusion and paste performance.
Stability: Volatiles are sensitive to light/heat/air; whole rhizomes retain aroma better than ground powder.

Food applications
Curry and chili pastes (typically 1–3% of paste mass), soups (tom kha, tom yum), stews and sauces, pickles and condiments, spice blends for meats/fish, and spiced beverages/infusions. For fresh use, bruised slices (~5–10 g/L stock) are simmered and removed before serving.

Nutrition and health
Culinary use levels yield negligible energy impact while delivering aromatic compounds. The essential oil contains eugenol and other bioactives that can be irritant at excess dose; food use should follow good practice without implying health claims.

Quality and specification themes
Verified botanical identity, purity, and moisture in range; free of molds and insects.
Essential-oil content and terpene composition consistent by GC–MS.
Cream–ocher color without undue browning; clean, non-earthy aroma.
Pesticides/metals within limits; compliant microbiology; full traceability under GMP/HACCP.

Storage and shelf life
Store cool, dry, and dark in well-sealed, low-permeability containers; control ambient RH to prevent caking and volatile loss.
Prefer whole rhizome for long storage; mill close to use.
Apply FIFO rotation; for essential oil, use dark glass, minimal headspace, and cool conditions.

Allergens and safety
Greater galangal is not a listed major allergen but may cause individual sensitization; essential oil is irritant to skin/mucosa if undiluted. Plant handling should limit dust, and CCPs should address foreign bodies.

Cosmetic (INCI) functions
Common listings: Alpinia Galanga Root Oil, Alpinia Galanga Root Extract. Reported roles: fragrance, masking, skin conditioning, supportive antioxidant, and mild antimicrobial functions in natural leave-on and rinse-off products.

Troubleshooting
Weak aroma: Over-hot drying or long storage → Reduce drying severity, improve barrier packaging, and grind on demand.
Excess bitter/camphor notes: Overdose or prolonged cooking → Lower inclusion and add nearer to end of cook.
Powder caking: High RH → Use better barrier packs and desiccants; improve logistics.
Darkening of slices: Enzymic/oxidative browning → Peel/slice and start drying promptly; consider mild antioxidant dips.

Sustainability and supply chain
Southeast Asian supply chains often involve smallholders; traceability programs and sustainable agronomy improve the ethical profile. Heat-recovery in drying, recyclable packaging, and effluent control to BOD/COD targets reduce environmental impact.

Conclusion
Greater galangal provides a distinctive, versatile flavor distinct from ginger, delivering camphoraceous citrus freshness across many dishes. Application quality hinges on rhizome maturity, gentle drying, protection of volatiles, and proper standardization of extracts.

Mini-glossary
GC–MS — Gas chromatography–mass spectrometry; used to fingerprint and verify essential-oil composition.
aw — Water activity; low aw in dried spices supports microbial and oxidative stability.
RH — Relative humidity; high RH promotes caking and volatile loss during storage.
EtOH — Ethanol; common hydroalcoholic solvent for food extracts/flavors.
SFE — Supercritical fluid extraction; CO₂-based process yielding selective aromatic extracts.
GMP — Good Manufacturing Practice; hygiene and process controls ensuring consistency and traceability.
HACCP — Hazard Analysis and Critical Control Points; preventive food-safety system with defined CCPs.
CCP — Critical control point; a step where control prevents, eliminates, or reduces a hazard to acceptable levels.
FIFO — First in, first out; inventory rotation principle—use the oldest lots first.
INCI — International Nomenclature of Cosmetic Ingredients; standardized cosmetic ingredient naming/functions.
BOD/COD — Biochemical/Chemical oxygen demand; indicators of organic load in effluents and environmental impact.
PV — Peroxide value; index of primary oxidation in oils and oleoresins.
AV — Anisidine value; index of secondary oxidation (aldehydes) in oils and oleoresins.

References__________________________________________________________________________

Kaushik D, Yadav J, Kaushik P, Sacher D, Rani R. Current pharmacological and phytochemical studies of the plant Alpinia galanga. Zhong Xi Yi Jie He Xue Bao. 2011 Oct;9(10):1061-5. doi: 10.3736/jcim20111004.

Abstract. Traditional medicine systems consist of large numbers of plants with medicinal and pharmacological importance and hence represent an invaluable reservoir of new bioactive molecules. Alpinia galanga (family Zingiberaceae) is commonly known as galangal and has been used for its emmenagogue, aphrodisiac, abortifacient, carminative, antipyretic and anti-inflammatory qualities and used in the treatment of various diseases such as bronchitis, heart diseases, chronic enteritis, renal calculus, diabetes, rheumatism and kidney disorders. It was reported to contain, among other components, essential oils, tannins, phenol, glycosides, monoterpenes and carbohydrates. In the last few years, new compounds such as gallic acid glycoside, galangoisoflavonoid,β-sitosterol, galangin, alpinin, zerumbone and kampferide have been isolated from various parts of A. galanga. Therefore, the present review is aimed to summarize the information regarding A. galanga concerning the new phytoconstituents and pharmacological uses that have appeared in recent years.

Ahlina FN, Nugraheni N, Salsabila IA, Haryanti S, Da'i M, Meiyanto E. Revealing the Reversal Effect of Galangal (Alpinia galanga L.) Extract Against Oxidative Stress in Metastatic Breast Cancer Cells and Normal Fibroblast Cells Intended as a Co- Chemotherapeutic and Anti-Ageing Agent. Asian Pac J Cancer Prev. 2020 Jan 1;21(1):107-117. doi: 10.31557/APJCP.2020.21.1.107. 

Abstract. Objective: This study intends to explore the potential of galangal extract as a co-chemotherapeutic agent through the analysis of its cytotoxic and migratory effects on metastatic breast cancer cells and as an anti-ageing agent through its senescence inhibitory effect on normal fibroblast cells. Methods: Galangal ethanolic extract (GE) was subjected to a cytotoxicity test with the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay alone or in combination with doxorubicin (Dox) against 4T1 cells but not in NIH-3T3 cells. Evidence of senescent cells was detected using a SA-β galactosidase based assay. In addition, the level of reactive oxygen species (ROS), apoptosis, and cell cycle were measured with a flow cytometry-based assay. Meanwhile, cell migration and matrix metalloproteinase (MMP)-9 expression after GE treatment on 4T1 cells were measured using the scratch wound healing assay and gelatin zymography assay, respectively. The metabolomic profiles of GE were traced using gas chromatography-mass spectrometry (GC-MS) analysis. Results: GE effectively inhibited the growth of 4T1 cells with an IC50 value of 135 µg/mL and increased the cytotoxic effect of Dox at concentrations of 50 and 100 µg/mL. GE increased the number of senescent cells arrested in the G2/M phase but did not cause apoptosis. This effect is compounded by increasing intracellular levels of ROS. However, GE reduced senescence to normal in fibroblast cells (NIH 3T3 cells) under oxidative stress by Dox without any changes in the ROS level. Moreover, GE also inhibited the migration of 4T1 cells and suppressed the expression of MMP-9 induced by Dox. Conclusion: Galangal has the potential for use as a co-chemotherapeutic agent by inducing senescence in correlation with increasing intracellular ROS toward metastatic breast cancer. However, the effect of GE in decreasing the senescence phenomena toward normal fibroblast cells illustrates its potential as a promising anti-ageing agent.

Lo CY, Liu PL, Lin LC, Chen YT, Hseu YC, Wen ZH, Wang HM. Antimelanoma and antityrosinase from Alpinia galangal constituents. ScientificWorldJournal. 2013 Aug 21;2013:186505. doi: 10.1155/2013/186505. 

Abstract. Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.

Rao K, Ch B, Narasu LM, Giri A. Antibacterial activity of Alpinia galanga (L) Willd crude extracts. Appl Biochem Biotechnol. 2010 Oct;162(3):871-84. doi: 10.1007/s12010-009-8900-9.

Abstract. Methanol, acetone and diethyl ether extracts of Alpinia galanga have been evaluated against pathogens viz. Bacillus subtilis MTCC 2391, Enterobacter aerogene, Enterobacter cloacae, Enterococcus faecalis, Escherichia coli MTCC 1563, Klebsiella pneumoniae, Pseudomonas aeruginosa MTCC 6642, Salmonella typhimurium, Staphylococcus aureus and Streptococcus epidermis using Agar well diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of all the extracts were determined using the macrodilution method. Methanol extracts have shown excellent activity towards all the pathogens with MIC and MBC values ranging from 0.04-1.28 mg/ml and 0.08-2.56 mg/ml, respectively. The GC-MS analysis of methanol extracts have yielded compounds like 5-hydroxymethyl furfural (59.9%), benzyl alcohol (57.6%), 1,8 cineole (15.65%), methylcinnamate (9.4%), 3-phenyl-2-butanone (8.5%) and 1,2 benzenedicarboxylic acid (8.9%), which could be responsible for its broad spectrum activity. So, A. galanga can be quite resourceful for the development of new generation drugs.

Ramanunny AK, Wadhwa S, Gulati M, Vishwas S, Khursheed R, Paudel KR, Gupta S, Porwal O, Alshahrani SM, Jha NK, Chellappan DK, Prasher P, Gupta G, Adams J, Dua K, Tewari D, Singh SK. Journey of Alpinia galanga from kitchen spice to nutraceutical to folk medicine to nanomedicine. J Ethnopharmacol. 2022 Jun 12;291:115144. doi: 10.1016/j.jep.2022.115144. 

Tang X, Xu C, Yagiz Y, Simonne A, Marshall MR. Phytochemical profiles, and antimicrobial and antioxidant activities of greater galangal [Alpinia galanga (Linn.) Swartz.] flowers. Food Chem. 2018 Jul 30;255:300-308. doi: 10.1016/j.foodchem.2018.02.027.

Ge X, Liang Q, Long Y, Shen H, Zhang Q, Sun Z, Li W. Assessment of fresh Alpinia galanga (A. galanga) drying techniques for the chemical composition of essential oil and its antioxidant and biological activity. Food Chem. 2022 Oct 30;392:133314. doi: 10.1016/j.foodchem.2022.133314. Epub 2022 May 26. PMID: 35636195.

Ramanunny AK, Wadhwa S, Kumar Singh S, Kumar B, Gulati M, Kumar A, Almawash S, Al Saqr A, Gowthamarajan K, Dua K, Singh H, Vishwas S, Khursheed R, Rahana Parveen S, Venkatesan A, Paudel KR, Hansbro PM, Kumar Chellappan D. Topical non-aqueous nanoemulsion of Alpinia galanga extract for effective treatment in psoriasis: In vitro and in vivo evaluation. Int J Pharm. 2022 Aug 25;624:121882. doi: 10.1016/j.ijpharm.2022.121882.

Kang MS, Park JH, Lee HS. Acaricidal potential of active components derived from Alpinia galanga rhizome oils and their derivatives against Haemaphysalis longicornis (Acari: Ixodidae). Exp Appl Acarol. 2022 Feb;86(2):313-326. doi: 10.1007/s10493-022-00685-z.