Hemp hearts (Hulled Hemp Seed)
Synonyms/labeling: shelled hemp seeds; dehulled hemp kernels; “hemp hearts”
Botanical source: Cannabis sativa L., edible inner kernel of the achene (hull removed), food-type cultivars with very low cannabinoids
Definition
Hemp hearts seeds are the dehulled kernels of industrial hemp. Removal of the fibrous hull concentrates lipids and proteins, yielding a tender, pale cream–green kernel with a nutty, sesame–pine-nut-like flavor. From food-type cultivars, they contain only trace cannabinoids (typically non-detectable in finished foods when properly processed).
Caloric value
~600 kcal per 100 g (typical range 570–630 kcal/100 g, varying with fat and moisture).
Indicative composition (per 100 g)
Fat: ~48–55 g
Fatty-acid profile (of total fat): linoleic acid (LA, ω-6) ~50–60%; α-linolenic acid (ALA, ω-3) ~15–25%; γ-linolenic acid (GLA, ω-6) ~2–4%; oleic ~10–15%; small stearidonic acid (SDA, ω-3) traces.
ω-6 : ω-3 ratio ≈ 3 : 1 (favorable among culinary seeds).
Protein: ~30–33 g (rich in edestin and albumin; highly digestible; lysine is the most limiting essential amino acid).
Carbohydrates: ~8–12 g
Moisture: ~3–6%
Ash (minerals): ~4–6%
Micronutrients (typical, per 100 g): Mg, P, K, Fe, Zn, Mn in meaningful amounts; vitamin E (tocopherols) and phytosterols in the unsaponifiable fraction.
Bioactive and functional components
Tocopherols (α, γ) and phytosterols support oxidative stability and nutrition.
GLA and traces of SDA provide uncommon ω-6/ω-3 intermediates in human diets.
Arginine-rich proteins (high Arg/Lys ratio) support a heart-healthy profile in epidemiological contexts (diet-level effect).
Processing overview
Cleaning → dehulling (impact/abrasion) → air classification and optical sorting to remove hull fines → optional light roasting or steam pasteurization for flavor and microbial control → metal detection → nitrogen-flushed or oxygen-barrier packaging. Co-products: hull fiber (feed/functional fiber). Seeds may alternatively be cold-pressed to make hemp oil; the press cake yields hemp protein flour.
Physicochemical & techno-functional properties
Appearance: cream to pale green kernels; soft, oily mouthfeel.
Water/fat binding: moderate water binding; high oil content gives lubricity and creamy texture when milled.
Emulsification: fine milling produces hemp “butter” or pastes with emulsion-forming capability (protein + phospholipids).
Oxidative stability: PUFA-rich → requires oxygen/light control; natural tocopherols help but are not sufficient alone.
Applications
Bakery & snacks: toppings for breads and crackers; inclusion in doughs/batters for nutty flavor and healthy fats (typical inclusion 5–20% of flour weight; adjust hydration and structure).
Granola/bars & cereals: 10–20% for protein/fat enrichment and crunch.
Dairy alternatives: base for hemp drinks, yogurts, and spreads when wet-milled and homogenized (use enzymes/emulsifiers to stabilize).
Smoothies, salads, dips: direct sprinkle or blended for creaminess (hemp “milk”/“butter”).
Oil pressing: kernels used for cold-pressed hemp oil (nutty flavor); press cake milled into hemp protein.
Formulation guidance (indicative)
Bread and baked goods: start at 5–10% replacement of flour; increase gradually up to 15–20% with gluten reinforcement (vital gluten) or hydrocolloids (xanthan/psyllium) to offset gluten dilution and added fat.
Plant beverages: 8–12% kernels (w/w in water) → wet mill → heat treat → homogenize; add 0.1–0.3% emulsifier (e.g., sunflower lecithin) and stabilize with 0.1–0.2% gellan or 0.2–0.4% locust bean gum.
Spreads/dips: mill kernels with water/oil to 30–60% solids; season; pasteurize; package under low O₂.
Nutrition & digestibility
Complete protein at the seed level (all essential amino acids present) but lysine is relatively lower vs soy; combine with lysine-richer foods (legumes) for amino-acid complementarity over the day.
PUFA-rich lipids with a 3:1 ω-6:ω-3 ratio; presence of GLA is distinctive among culinary seeds.
Lower fiber than whole hemp seed (hull removed); if higher fiber is desired, blend with oat/psyllium/flax.
Safety, legal, and allergen notes
Cannabinoids (THC/CBD): food-type cultivars and proper cleaning/dehulling yield very low to non-detectable cannabinoids. Jurisdictions set strict maximum residue limits—use compliant, tested lots (also screen for pesticides and mycotoxins).
Allergenicity: hemp seed allergy is rare but reported; label clearly and avoid cross-contact with major allergens where relevant.
Gluten: naturally gluten-free; maintain <20 ppm via validated controls if making GF claims.
Microbiology: low moisture favors stability; use validated pasteurization where required for ready-to-eat formats.
Stability & storage
Rancidity risk due to high PUFA: store cool (≤20 °C), dry, light-protected, in oxygen-barrier packs (prefer nitrogen flush).
Shelf life: typically 9–12 months unopened under optimal conditions; refrigerate after opening and use promptly.
Quality specifications (typical themes)
Moisture ≤ 6%; peroxide value low at pack; FFA controlled.
Hull fragments: minimal/none; foreign matter absent.
Nutrient targets: protein ≥30%, fat ≥48% (by weight), micro within finished-product standards.
Sensory: fresh nutty aroma, no bitterness or “painty” oxidative notes.
Environmental & sourcing
Industrial hemp is generally input-efficient, supports crop rotation, and can provide soil cover; choose suppliers with traceability, residue testing, and, where desired, organic certification.
Conclusion
Hulled hemp seeds are a nutrient-dense ingredient combining high-quality plant protein with a favorable ω-6:ω-3 profile and distinctive GLA content. Their pleasant nutty flavor, creamy texture when milled, and broad application range make them well-suited to better-for-you bakery, snacks, and plant-based dairy. Manage oxidation, hydration, and structure in formulations, and source from tested, compliant supply chains for consistent, safe performance.
References__________________________________________________________________________
Sirangelo TM, Diretto G, Fiore A, Felletti S, Chenet T, Catani M, Spadafora ND. Nutrients and Bioactive Compounds from Cannabis sativa Seeds: A Review Focused on Omics-Based Investigations. Int J Mol Sci. 2025 May 29;26(11):5219. doi: 10.3390/ijms26115219.
Abstract. Hemp (Cannabis sativa L.) is a versatile crop that can be processed to obtain different products with multiple applications. Its seeds are a well-documented ancient source of proteins, fibers and fats, all of which possess high nutritional value. Additionally, metabolites such as flavones and phenols are present in the seeds, contributing to their antioxidant properties. Due to hemp seeds' distinctive nutritional profile, the interest in exploring the potential use in food and nutraceuticals is growing, and they can be considered an interesting and promising alternative resource for human and animal feeding. Omics studies on hemp seeds and their by-products are also being developed, and they contribute to improving our knowledge about the genome, transcriptome, proteome, metabolome/lipidome, and ionome of these sustainable food resources. This review illustrates the main nutrients and bioactive compounds of hemp seeds and explores the most relevant omics techniques and investigations related to them. It also addresses the various products derived from processing the whole seed, such as oil, dehulled seeds, hulls, flour, cakes, meals, and proteins. Moreover, this work discusses research aimed at elucidating the molecular mechanisms underlying their protein, lipid, fiber, and metabolic profile. The advantages of using omics and multi-omics approaches to highlight the nutritional values of hemp seed by-products are also discussed. In our opinion, this work represents an excellent starting point for researchers interested in studying hemp seeds as source of nutrients and bioactive compounds from a multi-level molecular perspective.
Banskota AH, Jones A, Hui JPM, Stefanova R. Triacylglycerols and Other Lipids Profiling of Hemp By-Products. Molecules. 2022 Apr 5;27(7):2339. doi: 10.3390/molecules27072339.
Abstract. Hemp seed by-products, namely hemp cake (hemp meal) and hemp hulls were studied for their lipid content and composition. Total lipid content of hemp cake and hemp hulls was 13.1% and 17.5%, respectively. Oil extraction yields using hexane, on the other hand, were much lower in hemp cake (7.4%) and hemp hulls (12.1%). Oil derived from both hemp seeds and by-products were primarily composed of neutral lipids (>97.1%), mainly triacylglycerols (TAGs), determined by SPE and confirmed by NMR study. Linoleic acid was the major fatty acid present in oils derived from hemp by-products, covering almost 55%, followed by α-linolenic acid, covering around 18% of the total fatty acids. For the first time, 47 intact TAGs were identified in the hemp oils using UPLC-HRMS. Among them, TAGs with fatty acid acyl chain 18:3/18:2/18:2 and 18:3/18:2/18:1 were the major ones, followed by TAGs with fatty acid acyl chain of 18:3/18:3/18:2, 18:2/18:2/16:0, 18:2/18:2/18:1, 18:3/18:2.18:0, 18:2/18:2/18:0, 18:2/18:1/18:1 and 18:3/18:2:16:0. Besides TAGs, low levels of terpenes, carotenoids and cannabidiolic acid were also detected in the oils. Moreover, the oils extracted from hemp by-products possessed a dose-dependent DPPH radical scavenging property and their potencies were in a similar range compared to other vegetable oils.
Bárta J, Roudnický P, Jarošová M, Zdráhal Z, Stupková A, Bártová V, Krejčová Z, Kyselka J, Filip V, Říha V, Lorenc F, Bedrníček J, Smetana P. Proteomic Profiles of Whole Seeds, Hulls, and Dehulled Seeds of Two Industrial Hemp (Cannabis sativa L.) Cultivars. Plants (Basel). 2023 Dec 30;13(1):111. doi: 10.3390/plants13010111.
Abstract. As a source of nutritionally important components, hemp seeds are often dehulled for consumption and food applications by removing the hard hulls, which increases their nutritional value. The hulls thus become waste, although they may contain valuable protein items, about which there is a lack of information. The present work is therefore aimed at evaluating the proteome of hemp (Cannabis sativa L.) at the whole-seed, dehulled seed, and hull levels. The evaluation was performed on two cultivars, Santhica 27 and Uso-31, using LC-MS/MS analysis. In total, 2833 protein groups (PGs) were identified, and their relative abundances were determined. A set of 88 PGs whose abundance exceeded 1000 ppm (MP88 set) was considered for further evaluation. The PGs of the MP88 set were divided into ten protein classes. Seed storage proteins were found to be the most abundant protein class: the averages of the cultivars were 65.5%, 71.3%, and 57.5% for whole seeds, dehulled seeds, and hulls, respectively. In particular, 11S globulins representing edestin (three PGs) were found, followed by 7S vicilin-like proteins (four PGs) and 2S albumins (two PGs). The storage 11S globulins in Santhica 27 and Uso-31 were found to have a higher relative abundance in the dehulled seed proteome (summing to 58.6 and 63.2%) than in the hull proteome (50.5 and 54%), respectively. The second most abundant class of proteins was oleosins, which are part of oil-body membranes. PGs belonging to metabolic proteins (e.g., energy metabolism, nucleic acid metabolism, and protein synthesis) and proteins related to the defence and stress responses were more abundant in the hulls than in the dehulled seeds. The hulls can, therefore, be an essential source of proteins, especially for medical and biotechnological applications. Proteomic analysis has proven to be a valuable tool for studying differences in the relative abundance of proteins between dehulled hemp seeds and their hulls among different cultivars.
van Klinken BJ, Stewart ML, Kalgaonkar S, Chae L. Health-Promoting Opportunities of Hemp Hull: The Potential of Bioactive Compounds. J Diet Suppl. 2024;21(4):543-557. doi: 10.1080/19390211.2024.2308264.
Abstract. Hemp hull is the outer coat of the hemp seed, derived from the plant Cannabis sativa L., Cannabaceae. While much attention has been paid to hemp seed for its oil, protein and micronutrient content, far less attention has been given to hemp hull, a side stream of hemp processing. Hemp hull is a source of bioactive compounds, dietary fiber, minerals as well as protein, lipids and carbohydrates. Of note, two bioactive compounds, n-trans-caffeoyltyramine and n-trans-feruloyltyramine have been identified in hemp hull as key bioactive compounds that support gut health, liver function and other physiological processes. Both of these compounds were identified as agonists of the transcription factor, hepatic nuclear factor-4 alpha which has been implicated in gene expression that governs gut permeability, factors associated with inflammatory bowel diseases, and hepatic lipid homeostasis. Additionally, the dietary fibers in hemp hull have been demonstrated to be novel prebiotics, which may further amplify hemp hull's effect on gut health and metabolic health. This review article summarizes the nutritional content of hemp hull, explores the physiological effects of bioactive compounds found in hemp hull, and identifies opportunities for further research on hemp hull for human health benefit.
House JD, Neufeld J, Leson G. Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method. J Agric Food Chem. 2010 Nov 24;58(22):11801-7. doi: 10.1021/jf102636b.
Abstract. The macronutrient composition and the quality of protein of hemp seed and products derived from hemp seed grown in Western Canada were determined. Thirty samples of hemp products (minimum 500 g), including whole hemp seed, hemp seed meal from cold-press expelling, dehulled, or shelled, hemp seed and hemp seed hulls, were obtained from commercial sources. Proximate analysis, including crude protein (% CP), crude fat (% fat) and fiber, as well as full amino acid profiles, were determined for all samples. Protein digestibility-corrected amino acid score (PDCAAS) measurements, using a rat bioassay for protein digestibility and the FAO/WHO amino acid requirement of children (2-5 years of age) as reference, were conducted on subsets of hemp products. Mean (±SD) percentage CP and fat were 24.0(2.1) and 30.4(2.7) for whole hemp seed, 40.7(8.8) and 10.2(2.1) for hemp seed meal, and 35.9(3.6) and 46.7(5.0) for dehulled hemp seed. The percentage protein digestibility and PDCAAS values were 84.1-86.2 and 49-53% for whole hemp seed, 90.8-97.5 and 46-51% for hemp seed meal, and 83.5-92.1 and 63-66% for dehulled hemp seed. Lysine was the first limiting amino acid in all products. Removal of the hull fraction improved protein digestibility and the resultant PDCAAS value. The current results provide reference data in support of protein claims for hemp seed products and provide evidence that hemp proteins have a PDCAAS equal to or greater than certain grains, nuts, and some pulses.
Banskota AH, Tibbetts SM, Jones A, Stefanova R, Behnke J. Biochemical Characterization and In Vitro Digestibility of Protein Isolates from Hemp (Cannabis sativa L.) By-Products for Salmonid Feed Applications. Molecules. 2022 Jul 27;27(15):4794. doi: 10.3390/molecules27154794.
Abstract. Hemp (Cannabis sativa L.) processing by-products (hemp cake and hemp seed hulls) were studied for their protein content, extraction of protein isolates (PIs), and their in vitro protein digestibility (IVPD). Crude protein contents of hemp cake and hemp seed hulls were 30.4% and 8.6%, respectively, calculated based on generalized N-to-P conversion factor (N × 5.37). Extraction efficiency of PIs from defatted biomass ranged from 56.0 to 67.7% with alkaline extraction (0.1 M NaOH) followed by isoelectric precipitation (1.0 M HCl). Nitrogen analysis suggested that the total protein contents of PIs extracted using three different alkaline conditions (0.5 M, 0.1 M, and pH 10.0 with NaOH) were >69.7%. The hemp by-product PIs contained all essential amino acids (EAAs) required for fish with leucine, valine, and phenylalanine belonging to the five dominant amino acids. Overall, glutamate was the dominant non-EAA followed by aspartate. Coomassie staining of an SDS-PAGE gel revealed strong presence of the storage protein edestin. High IVPD of >88% was observed for PIs extracted from hemp seeds and by-products when evaluated using a two-phase in vitro gastric/pancreatic protein digestibility assay. PIs extracted from by-products were further tested for their antioxidant activities. The tested PIs showed dose-dependent DPPH radical scavenging activity and possessed strong ORAC values > 650 μM TE/g.