Angelica Archangelica Callus Extract is derived from the callus tissue of the Angelica archangelica (Apiaceae) plant, commonly known as garden angelica or wild celery. This extract is obtained from the undifferentiated cells of the plant and is known for its regenerative properties. In cosmetic formulations, Angelica Archangelica Callus Extract is valued for its antioxidant, anti-inflammatory, and skin-rejuvenating benefits. It helps to improve skin texture, enhance hydration, and promote a youthful appearance.
Chemical Composition and Structure
Angelica Archangelica Callus Extract contains:
- Phytochemicals: Rich in flavonoids, phenolic compounds, and other bioactive components that provide antioxidant and anti-inflammatory effects.
- Vitamins: Contains essential vitamins that contribute to maintaining healthy skin.
- Amino Acids: Provides amino acids that support skin health and regeneration.
- Minerals: Supplies essential minerals necessary for skin function.
The unique composition of Angelica Archangelica Callus Extract allows it to effectively nourish, protect, and revitalize the skin.
Physical Properties
Appearance: Typically a light to dark brown liquid or viscous extract.
Solubility: Soluble in water and alcohol; limited solubility in oils.
pH: Generally neutral to slightly acidic, ensuring compatibility with various cosmetic formulations.
Odor: Mild, herbal scent characteristic of angelica.
Stability: Stable under normal storage conditions; should be protected from excessive heat and light.
Production Process
Cell Culture: Callus tissue is cultivated from the Angelica archangelica plant under controlled conditions to encourage undifferentiated cell growth.
Extraction: The callus tissue is processed to obtain the extract, typically using methods such as solvent extraction to retain beneficial properties.
Purification: The extract is purified to remove impurities and ensure a high-quality product.
Formulation: Purified Angelica Archangelica Callus Extract is incorporated into various cosmetic products to enhance their soothing and nourishing properties.
Applications
Medical: Used in topical formulations for its regenerative properties and ability to reduce skin irritation and inflammation.
Cosmetics: Commonly found in anti-aging creams, serums, and lotions for its rejuvenating and hydrating benefits. It improves skin texture and promotes a healthier, more youthful appearance.
INCI Functions:
Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.
CAS 84775-41-7
EC number 283-871-1
Environmental and Safety Considerations
Generally regarded as safe for topical application, however, like all extracts, it should be used in accordance with established guidelines to avoid potential allergic reactions or skin irritations.
People with allergies or very sensitive skin should be careful.
It is important to ensure that the extract is sustainably sourced and free from harmful chemicals.
Studies
Medical
Angelica archangelica is an important medicinal plant and its fruits, flowers, stems and roots are used in traditional medical medicine to treat disorders of the respiratory tract, gastrointestinal tract and nervous system. Tannins, saponins, phenolic compounds and flavonoids are found in the root, giving the root extract antioxidant properties, and chemical compounds such as coumarin and decursinol have shown efficacy against mild cognitive decline in elderly subjects (1).
Furthermore, recent studies have also discovered antidepressant activity produced by components such as coumarin, angelicin and bergapten (2).
Angelica archangelica has demonstrated protective effects on collagen degradation in dermal fibroblasts due to UV irradiation (3).

Minerals present include, in order of quantity:
- magnesium
- potassium
- calcium
- phosphorus
Cosmetics
The root extract of this plant has shown efficacy in protecting collagen degradation in dermal fibroblasts and may be considered a promising agent for use against photo-ageing of the skin.
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