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admin (19653 pt) 2024-Oct-02 17:46

Arginine/lysine polypeptide is a synthetic peptide composed of the amino acids arginine and lysine, both of which are essential components of the skin’s natural moisturizing and protective functions. This polypeptide is primarily used in skincare formulations due to its ability to support the skin's natural defense mechanisms and enhance hydration. It is also known for its anti-aging and skin-soothing properties, making it suitable for sensitive or irritated skin. Arginine/lysine polypeptide can help restore the skin’s barrier function, protect against environmental stressors, and promote a youthful appearance.

Chemical Composition and Structure
Arginine/lysine polypeptide is a chain of amino acids derived from the natural building blocks of proteins—arginine and lysine. Both are positively charged, basic amino acids that play key roles in cellular metabolism and skin health. The polypeptide is formed by linking these amino acids into a chain, creating a compound that supports the skin’s natural repair processes. Arginine stimulates collagen production, while lysine aids in the repair and regeneration of damaged skin tissue, making this polypeptide particularly effective in anti-aging and skin-healing formulations.

Physical Properties
Arginine/lysine polypeptide is typically found as a white or off-white powder or liquid solution, depending on its formulation. It is soluble in water and can be easily incorporated into various skincare and cosmetic products. The ingredient is stable across a wide range of pH levels and temperatures, making it versatile for use in creams, serums, and lotions. Due to its hydrophilic nature, it helps retain moisture in the skin, contributing to long-lasting hydration.

Production Process
The production of arginine/lysine polypeptide involves the following steps:

  1. Peptide Synthesis: Arginine and lysine are chemically synthesized and linked together using standard peptide synthesis techniques, such as solid-phase peptide synthesis, to create a polypeptide chain.

  2. Purification: The polypeptide is purified to remove any byproducts or residual chemicals, ensuring a high-quality ingredient suitable for cosmetic and skincare use.

  3. Formulation: Once purified, arginine/lysine polypeptide is formulated into cosmetic products, often combined with other moisturizing and anti-aging ingredients to maximize its efficacy.

Applications

  • Anti-Aging Skincare: Arginine/lysine polypeptide is commonly found in anti-aging products where it helps promote collagen synthesis, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It also aids in the regeneration of skin cells, making it a popular ingredient in creams and serums designed to restore a youthful appearance.

  • Moisturizers: This polypeptide is used in moisturizers due to its ability to enhance the skin’s hydration levels by binding water to the skin’s surface and preventing moisture loss. It helps maintain a smooth and supple complexion.

  • Sensitive Skin Treatments: Arginine/lysine polypeptide is known for its soothing properties, making it ideal for products targeting sensitive or irritated skin. It helps calm inflammation and supports the skin’s natural healing processes, making it a valuable addition to products for eczema, rosacea, and other skin conditions.

INCI Functions:

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS: 31014-78-5

  • Wound Healing and Repair: Due to its role in cellular repair, arginine/lysine polypeptide is also used in formulations intended for skin healing, helping to repair damaged tissues and support the regeneration of the skin barrier.

Environmental and Safety Considerations
Arginine/lysine polypeptide is generally considered safe for topical use and is well-tolerated by most skin types, including sensitive and compromised skin. It is non-toxic, non-irritating, and does not sensitize the skin. The polypeptide is biodegradable and does not pose any significant environmental risk when used in rinse-off products. 

Since it is a synthetic compound, its production does not involve the harvesting of natural resources, reducing its ecological footprint.

References__________________________________________________________________________

Avcil, M., Akman, G., Klokkers, J., Jeong, D., & Çelik, A. (2020). Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. Journal of Cosmetic Dermatology, 19(2), 328-337.

Abstract. Background. Aging skin is a gradual physiological process associated with functional and structural changes of the skin. Both intrinsic and extrinsic factors influence skin aging by the involvement of multiple pathways. Restoring natural skin conditions requires a multi-targeted approach. Recent developments in both bioactive peptides and microneedle delivery system have presented an opportunity for tackling premature skin aging. Aims.This study was aimed at evaluating the dermal tolerability and efficacy of hyaluronic acid-based microneedle patches loaded with bioactives for restoration of the skin properties including hydration, wrinkle reduction, density, and thickness.....Conclusions. The composition of the microneedle patches works in a multi-targeted manner and all ingredients might possibly be acted synergistically for the improvement of skin structure, function, and appearance. The study has demonstrated the overall usefulness of the HA-MNs with careful formulation for skin care applications.

Chudzińska, J., Wawrzyńczak, A., & Feliczak-Guzik, A. (2024). Microneedles Based on a Biodegradable Polymer—Hyaluronic Acid. Polymers, 16(10), 1396.

Abstract. Transdermal transport can be challenging due to the difficulty in diffusing active substances through the outermost layer of the epidermis, as the primary function of the skin is to protect against the entry of exogenous compounds into the body. In addition, penetration of the epidermis for substances hydrophilic in nature and particles larger than 500 Da is highly limited due to the physiological properties and non-polar nature of its outermost layer, namely the stratum corneum. A solution to this problem can be the use of microneedles, which “bypass” the problematic epidermal layer by dispensing the active substance directly into the deeper layers of the skin. Microneedles can be obtained with various materials and come in different types. Of special interest are carriers based on biodegradable and biocompatible polymers, such as polysaccharides. Therefore, this paper reviews the latest literature on methods to obtain hyaluronic acid-based microneedles. It focuses on the current advancements in this field and consequently provides an opportunity to guide future research in this area.

Li, X. H., Su, W. R., & Wang, F. F. (2023). Computational biology in topical bioactive peptide discovery for cosmeceutical application: a concise review. Biomed Eng Commun, 2(3), 14.

Abstract. Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field, targeting potential treatments with skin therapeutic and intervention pathways, which make it possible to develop effective skin regeneration and repair ingredients. With the rapid development of computational biology, bioinformatics as well as artificial intelligence (A.I.), the development of new ingredients for regenerative medicine has been greatly accelerated, and the success rate has been improved. Some application cases have appeared in topical skin regeneration and repair scenarios. This review will briefly introduce the application of bioactive peptides in skin repair and anti-aging as emerging ingredients in cosmeceutics and emphasize how A.I. based computational biology technology may accelerate the development of innovative peptide molecules and ultimately translate them into potential skin regenerative and anti-aging scenarios. Typically, two research routines have been summarized and current limitations as well as directions were discussed for border applications in future research.