Description

Palmitoyl sh-Tripeptide-2 Amide is the product obtained by the reaction of palmitic acid and sh-Tripeptide-2, in which the C-terminus of the peptide is modified to an amide. This compound is utilized in cosmetic formulations for its skin-rejuvenating and anti-aging properties.

Chemical Composition and Structure

Palmitoyl sh-Tripeptide-2 Amide consists of:

sh-Tripeptide-2: a synthetic peptide sequence composed of three amino acids, known for its specific biological functions in skin care.
Palmitic acid: a fatty acid esterified to the peptide to enhance its stability and skin penetration.
Amide group: modification of the C-terminus of the peptide to an amide, which influences the peptide’s stability and biological activity.

Physical Properties

Palmitoyl sh-Tripeptide-2 Amide has the following characteristics:

Appearance: typically a white or off-white powder, or a clear solution depending on the formulation.
Solubility: generally soluble in water and oils due to the palmitoyl modification.
Stability: improved stability in cosmetic formulations due to the palmitoyl group and amide modification.

Production Process

The production process for Palmitoyl sh-Tripeptide-2 Amide involves:

Reaction: palmitic acid reacts with sh-Tripeptide-2. The C-terminus of the peptide is modified to an amide, enhancing its stability and efficacy.
Purification: the reaction mixture is purified to remove impurities and isolate the high-purity peptide product.
Formulation: the purified Palmitoyl sh-Tripeptide-2 Amide is incorporated into cosmetic products such as creams and serums.
Quality Control: the final product undergoes rigorous testing for purity, stability, and efficacy to ensure it meets safety and performance standards.

Applications

Medical: not specifically used for medical purposes; primarily used in cosmetic applications.
Cosmetics: employed in anti-aging and skin-rejuvenating products. It helps improve skin texture, reduce the appearance of fine lines and wrinkles, and enhance overall skin health.
Others: mainly used in skin care formulations aimed at improving skin appearance and texture.

Environmental and Safety Considerations

Palmitoyl sh-Tripeptide-2 Amide is deemed safe for use in cosmetics when used according to established guidelines. The production process is designed to minimize environmental impact, and the final product undergoes comprehensive safety and efficacy testing. Proper disposal and management practices are followed to ensure minimal environmental impact.

INCI


Humectant. Hygroscopic compound used to minimise water loss in the skin and to prevent it from drying out by facilitating faster and greater absorption of water into the stratum corneum of the epidermis. The epidermis is the most superficial of the three layers that make up human skin (epidermis, dermis and hypodermis) and is the layer that maintains hydration in all three layers. In turn, the epidermis is composed of five layers: horny, the most superficial, granular, spinous, shiny, and basal. Humectants have the ability to retain the water they attract from the air in the stratum corneum and have the function of moisturising the skin. They are best used before emollients, which are oil-based.

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.
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