N-Prolyl Palmitoyl Tripeptide-56 Acetate is a synthetic peptide used in cosmetic formulations for its potential anti-aging and skin rejuvenation properties. It is the acetate salt of Palmitoyl Tripeptide-56, where the N6 position of the peptide is modified by proline. This modification enhances the stability and efficacy of the peptide in skin care products.

Chemical Composition and Structure

N-Prolyl Palmitoyl Tripeptide-56 Acetate is composed of:

Tripeptide Sequence: A chain of three amino acids forming Palmitoyl Tripeptide-56, which may include specific amino acids such as proline, lysine, and others.
Palmitoyl Group: A fatty acid chain (palmitic acid) attached to the peptide through a chemical reaction, enhancing the peptide’s penetration into the skin and its adhesion to skin cells.
Proline Modification: The N6 position of the peptide is modified by proline, which can affect the peptide's biological activity and stability.
Acetate Salt: The peptide is present as its acetate salt form, which improves solubility and stability in cosmetic formulations.

Physical Properties

N-Prolyl Palmitoyl Tripeptide-56 Acetate is characterized by:

Appearance: Typically a white or off-white powder, or in solution depending on the formulation.
Solubility: Soluble in water due to the acetate salt form, which facilitates its incorporation into aqueous formulations.
Stability: The proline modification and acetate salt form contribute to the peptide’s stability and prolonged efficacy in cosmetic products.

Production Process

The production process for N-Prolyl Palmitoyl Tripeptide-56 Acetate includes:

Reaction: Palmitoyl Tripeptide-56 is reacted with proline to modify the N6 position. The peptide is then converted into its acetate salt form through a reaction with acetic acid or an acetate salt.
Purification: The product is purified to remove any residual reagents or impurities, ensuring high purity and effectiveness.
Formulation: The purified N-Prolyl Palmitoyl Tripeptide-56 Acetate is incorporated into skin care products, such as serums and creams, during the formulation process.
Quality Control: The final product undergoes rigorous testing for purity, potency, and stability to ensure it meets safety and efficacy standards.

Applications

Medical: N-Prolyl Palmitoyl Tripeptide-56 Acetate is mainly used in cosmetic applications rather than medical ones. Its benefits are focused on improving skin health and appearance.
Cosmetics: Employed in anti-aging products to stimulate collagen production, enhance skin elasticity, and reduce the appearance of wrinkles and fine lines. Commonly used in serums, moisturizers, and facial creams.
Others: Occasionally used in other personal care products aimed at improving skin texture and reducing signs of aging.

Environmental and Safety Considerations

N-Prolyl Palmitoyl Tripeptide-56 Acetate is considered safe for use in cosmetic formulations when applied according to guidelines. The production process is managed to minimize environmental impact, and the final product undergoes rigorous quality control to ensure safety and effectiveness. Proper disposal and management practices are followed to maintain environmental safety.

INCI


Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.
Synonyms:

CAS: 1899049-18-3