Description

Chlorella Vulgaris sh-Polypeptide-14 is a single-chain recombinant human peptide produced by Chlorella vulgaris after transformation with either a transient expression system or transgenesis (stable insertion of a copy of a human gene into its DNA). The starting gene is synthesized to be identical to the human gene that codes for Nerve Growth Factor Beta (NGF-β). This bioengineered peptide is highly valued in the cosmetic and personal care industry for its potential to enhance skin regeneration, improve skin texture, and provide anti-aging benefits.

Chemical Composition and Structure
Chlorella Vulgaris sh-Polypeptide-14 contains a sequence of up to 53 amino acids, which may include disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids, mimicking the structure and function of naturally occurring peptides in the human body.

Amino Acids: The building blocks of proteins, essential for nourishing and strengthening the skin.
Recombinant Protein: Produced through bioengineering techniques, ensuring high purity and consistency.
Disulfide Bonds: Provide structural stability to the peptide.
Glycosylation: Enhances the stability and bioactivity of the peptide.
Physical Properties
Chlorella Vulgaris sh-Polypeptide-14 typically appears as a clear to slightly cloudy liquid or as a powder, depending on the formulation and processing method. It is easily incorporated into various cosmetic formulations, making it suitable for use in creams, serums, masks, and lotions.

Cosmetic and Personal Care Applications
Skin Regeneration: The peptide stimulates the production of new skin cells, promoting faster regeneration and healing of the skin.

Anti-Aging: Chlorella Vulgaris sh-Polypeptide-14 helps reduce the appearance of fine lines and wrinkles by boosting collagen and elastin production, improving skin elasticity.

Moisturizing: The peptide helps maintain skin hydration by attracting and retaining moisture, making it beneficial for dry and sensitive skin.

Nourishing: The rich content of amino acids provides essential nutrients to the skin, promoting overall health and vitality.

Skin Conditioning: The peptide helps improve the texture and appearance of the skin, making it softer and more resilient.

Soothing: The peptide’s ability to calm and soothe the skin makes it ideal for use in products designed for sensitive or irritated skin.

Environmental and Safety Considerations

Chlorella Vulgaris sh-Polypeptide-14 is generally considered safe for use in cosmetic and personal care products. It is well-tolerated by most skin types, including sensitive skin. The production process is environmentally friendly and sustainable, utilizing bioengineering and microalgae cultivation methods that have a low environmental impact.

Cosmetics - INCI Functions


Antimicrobial agent. This ingredient is able to suppress or inhibit the growth and replication of a broad spectrum of microorganisms such as bacteria, fungi and viruses by making the stratum corneum temporarily bactericidal and fungicidal.

Antioxidant agent. Ingredient that counteracts oxidative stress and prevents cell damage. Free radicals, pathological inflammatory processes, reactive nitrogen species and reactive oxygen species are responsible for the ageing process and many diseases caused by oxidation.

Hair conditioning agent. A significant number of ingredients with specific and targeted purposes may co-exist in hair shampoo formulations: cleansers, conditioners, thickeners, matting agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersants that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioning agents includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners. They can perform their task generally accompanied by other different ingredients.

Skin conditioning agent - Emollient. Emollients have the characteristic of enhancing the skin barrier through a source of exogenous lipids that adhere to the skin, improving barrier properties by filling gaps in intercorneocyte clusters to improve hydration while protecting against inflammation. In practice, they have the ability to create a barrier that prevents transepidermal water loss. Emollients are described as degreasing or refreshing additives that improve the lipid content of the upper layers of the skin by preventing degreasing and drying of the skin. The problem with emollients is that many have a strong lipophilic character and are identified as occlusive ingredients; they are oily and fatty materials that remain on the skin surface and reduce transepidermal water loss. In cosmetics, emollients and moisturisers are often considered synonymous with humectants and occlusives.

Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.
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