Only take under medical supervision.
Bromhexine Hydrochloride is a chemical compound used as an active ingredient in cough medicines. It is known for its effectiveness in facilitating the expulsion of mucus from the respiratory tract.
The name describes the structure of the molecule:
- Brom indicates the presence of bromine in the chemical structure.
- hexine is derived from "hexane", suggesting a specific chemical structure commonly associated with organic compounds.
- Hydrochloride indicates that the compound is formed by combining with hydrochloric acid, usually to increase the solubility or stability of the medication.
Chemical Industrial Synthesis Process
- Preparation of reagents. The key chemical reagents for the synthesis of Bromhexine include 2-amino-3,5-dibromobenzaldehyde and the cyclic amino compound needed to form the base structure of Bromhexine.
- Synthesis. The 2-amino-3,5-dibromobenzaldehyde is reacted with the cyclic amino compound in a condensation reaction to form the base compound of Bromhexine.
- Hydrogenation and chlorination. The base compound is then hydrogenated to reduce double bonds, followed by a chlorination reaction to introduce the hydrochloride group, forming Bromhexine hydrochloride.
- Purification. The crude Bromhexine hydrochloride is purified through crystallization or chromatography techniques to remove impurities and achieve high purity.
- Quality control. The purified product undergoes rigorous chemical and microbiological testing to ensure it is safe, effective, and meets pharmaceutical standards.
What it is used for and where
Medical
Bromhexine Hydrochloride is primarily used for the treatment of respiratory disorders involving excessive mucus production. It works by breaking down the chemical bonds in mucus, making it less viscous and easier to expel (1). This helps to improve breathing and facilitates productive coughing. It is commonly found in cough syrups and tablets for the treatment of conditions such as bronchitis and other chronic respiratory diseases.
The use of Bromexine Hydrochloride is suggested as a TMPRSS2 protease blocker that precludes SARS-CoV-2 penetration into cells and at a reduced rate of symptomatic COVID-19 (2).
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Molecular Formula C14H21Br2ClN2
Molecular Weight 412.59 g/mol
CAS 611-75-6
UNII YC2ZOM3Z8V
EC Number 210-280-8
DTXSID0045886
Synonyms:
Bromhexine HCl
