Moringa Oleifera bark Extract is a product of natural origin that comes from the bark of the Moringa Oleifera tree, Belonging to the botanical family Moringaceae, often referred to as the "drumstick tree" or "horseradish tree".
Industrial Production Process
- Bark Harvesting: Moringa Oleifera bark is harvested from the trees, taking care not to damage the tree. Harvesting is done manually and sustainably to preserve the health and future growth of the plant.
- Drying: After harvesting, the bark is washed and then dried. Drying can occur in the shade or using controlled temperature dryers to best preserve the bioactive compounds.
- Grinding: The dried bark is then ground into a fine powder. This increases the contact surface for extraction, facilitating the release of bioactive compounds.
- Extraction: The bark powder undergoes an extraction process using solvents such as water, ethanol, or a mixture of both, depending on the specific properties desired in the final extract. Extraction can be performed hot or cold.
- Filtration and Concentration: The obtained liquid extract is filtered to remove solid residues and then concentrated under vacuum to reduce solvent content, thus obtaining a concentrated extract.
- Purification: If necessary, the extract can be further purified to remove impurities and concentrate the active principles.
- Quality Control: The Moringa Oleifera bark extract undergoes quality control checks to verify the concentration of active ingredients, purity, and the absence of contaminants. These tests can include spectroscopic, chromatographic, and microbiological analyses.
Moringa oleifera bark extract is typically a viscous liquid ranging in color from light brown to green.
What it is for and where
Medical
Traditionally, Moringa leaves, bark and seeds have been used to treat edema, arthritis, epilepsy and other health problems.
Phytochemical analysis found beta-carotene, vitamin C, vitamin E, and polyphenols with antioxidant activity (1), lecithin with antibacterial activity (2), and the ethyl acetate fraction showed strong anti-inflammatory activity (3).
Cosmetics
Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.
CAS 93165-54-9
Commercial Applications
Dietary Supplements. Moringa oleifera bark extract is rich in antioxidants, vitamins, and minerals, making it a valuable ingredient in dietary supplements aimed at supporting overall health, boosting the immune system, and improving skin health.
Cosmetic Products. Due to its anti-inflammatory, antimicrobial, and moisturizing properties, the bark extract is employed in a variety of cosmetic products, including skin creams, lotions, serums, and hair care products, to help nourish, protect, and regenerate the skin and hair.
Pharmaceutical Products. Moringa oleifera bark extract is also used in some pharmaceutical products for its potential therapeutic properties, including antidiabetic, antihypertensive, and anti-inflammatory effects, contributing to the treatment of various health conditions.
References_____________________________________________________________________
(1) Mahmood, K. T., Mugal, T., & Haq, I. U. (2010). Moringa oleifera: a natural gift-A review. Journal of Pharmaceutical Sciences and Research, 2(11), 775.
Abstract. Moringa oleifera, Lam {Syn M.pterygosperma Gaertn} usually mentioned in literature as Moringa, is a natural as well as cultivated variety of the genus Moringa belonging to family Moringaceae .It is one of the richest plant sources of Vitamins A ,B {1,2,3,6,7}, C,D,E and K. The vital minerals present in Moringa include Calcium, Copper, Iron, Potassium, Magnesium, Manganese and Zinc. It has more than 40 natural anti-oxidants. Moringahas been used since 150B.C. by ancient kings and queens in their diet for mental alertness and healthy skin. The leaves, pods, seeds, gums , bark and flowers of Moringa are used in more than 80 countries {including Pakistan} to relieve mineral and vitamin deficiencies, support a healthy cardiovascular system, promote normal blood-glucose levels, neutralize free radicals {thereby reducing malignancy}, provide excellent support of the body's anit-flammatory mechanisms, enrich anemic blood and support immune system. It also improveseyesight, mental alertness and bone strength. It has potential benefit in malnutrition, general weakness, lactatingmothers, menopause, depression and osteoporosis. It is also used to make an efficient fuel, fertilizer and livestock feed. Moringa is an edible extremely safe plant. Its tree could easily and cheaply be cultivated and grown in Pakistan.
(2) Moura MC, Napoleão TH, Coriolano MC, Paiva PM, Figueiredo RC, Coelho LC. Water-soluble Moringa oleifera lectin interferes with growth, survival and cell permeability of corrosive and pathogenic bacteria. J Appl Microbiol. 2015 Sep;119(3):666-76. doi: 10.1111/jam.12882.
(3) Arulselvan P, Tan WS, Gothai S, Muniandy K, Fakurazi S, Esa NM, Alarfaj AA, Kumar SS. Anti-Inflammatory Potential of Ethyl Acetate Fraction of Moringa oleifera in Downregulating the NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated Macrophages. Molecules. 2016 Oct 31;21(11):1452. doi: 10.3390/molecules21111452.
Abstract. In the present investigation, we prepared four different solvent fractions (chloroform, hexane, butanol, and ethyl acetate) of Moringa oleifera extract to evaluate its anti-inflammatory potential and cellular mechanism of action in lipopolysaccharide (LPS)-induced RAW264.7 cells. Cell cytotoxicity assay suggested that the solvent fractions were not cytotoxic to macrophages at concentrations up to 200 µg/mL. The ethyl acetate fraction suppressed LPS-induced production of nitric oxide and proinflammatory cytokines in macrophages in a concentration-dependent manner and was more effective than the other fractions. Immunoblot observations revealed that the ethyl acetate fraction effectively inhibited the expression of inflammatory mediators including cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor (NF)-κB p65 through suppression of the NF-κB signaling pathway. Furthermore, it upregulated the expression of the inhibitor of κB (IκBα) and blocked the nuclear translocation of NF-κB. These findings indicated that the ethyl acetate fraction of M. oleifera exhibited potent anti-inflammatory activity in LPS-stimulated macrophages via suppression of the NF-κB signaling pathway.
