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Description

Al222
Al222 (25124 pt) 2024-Feb-23 17:41

Echinacea Angustifolia Cell Culture Extract is a naturally derived compound from the plant Echinacea Angustifolia belonging to the Asteraceae family.

Industrial Production Process

The production of Echinacea Angustifolia cell culture extract, a valuable ingredient for its immunostimulating and protective properties used in cosmetics and herbal medicine, employs advanced cell culture techniques. This process allows for the extraction of extracts rich in specific active ingredients, leveraging the potential of plant cells in culture. Here is a detailed overview of the process.

  • Initiation. The process begins with the selection of healthy Echinacea Angustifolia tissues, which are sterilized and placed in a specific culture medium under aseptic conditions. This environment promotes the growth and proliferation of plant cells.
  • Growth. The cells are cultivated in incubators with controlled conditions of light, temperature, and humidity. During this phase, plant hormones and nutrients may be added to the culture medium to stimulate cell growth and the accumulation of active principles.
  • Harvesting. Once the cell cultures have reached an optimal density, they are harvested for the extraction of bioactive compounds. Extraction can be performed using solvents such as ethanol or water, or through gentler extraction methods to preserve the integrity of the compounds.
  • Purification. The obtained extracts are then purified to remove any impurities and concentrated to increase the level of active ingredients. This may include techniques such as filtration, chromatography, and vacuum evaporation.
  • Quality Control. The Echinacea Angustifolia cell culture extracts undergo quality control checks to confirm the presence and concentration of bioactive compounds, as well as to ensure the absence of contaminants. These tests can include chromatographic analyses, spectroscopic analyses, and biological activity tests.

Form and Color. Echinacea Angustifolia cell culture extract typically appears as a colorless or slightly yellow liquid, with a consistency that can vary based on concentration and extraction method.

What it is for and where

Cosmetics - INCI Functions

Antioxidant agent. Ingredient that counteracts oxidative stress and prevents cell damage. Free radicals, pathological inflammatory processes, reactive nitrogen species and reactive oxygen species are responsible for the ageing process and many diseases caused by oxidation.

Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.

CAS   84696-11-7

EC number   283-631-6

Cosmetic Properties. This extract is known for its excellent anti-inflammatory, healing, and immunostimulant properties. It is particularly valued in cosmetic products for sensitive or damaged skin care.

Applications. It is used in a wide range of cosmetic formulations, such as creams, serums, lotions, and masks, for its benefits in promoting skin health and vitality.

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Echinacea Angustifolia, also known as narrow-leaved coneflower, is a perennial plant in the Asteraceae family. Native to North America, it is well-known for its medicinal properties, particularly for boosting the immune system.

Chemical Composition

The plant contains a variety of bioactive compounds, including alkylamides, polysaccharides, and phenolic compounds, which provide immunomodulatory, antioxidant, and antimicrobial properties.

Activities.

Extracts of Echinacea Angustifolia have shown significant antioxidant and anti-inflammatory effects. Research has highlighted its potential in enhancing immune response and reducing inflammation.

Therapeutic Potential.

Traditionally, Echinacea Angustifolia has been used to treat colds, flu, and other respiratory infections, as well as being used to strengthen the body's natural defenses.

Applications.

Extracts of Echinacea Angustifolia are used in the production of dietary supplements and pharmaceutical products due to their health-beneficial properties. They are also used in the cosmetic industry for their beneficial skin properties.

References_____________________________________________________________________

(1) Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005 Aug;57(8):929-54. doi: 10.1211/0022357056127. PMID: 16102249.

Abstract. This paper reviews the chemistry, pharmacology and clinical properties of Echinacea species used medicinally. The Echinacea species Echinacea angustifolia, Echinacea pallida and Echinacea purpurea have a long history of medicinal use for a variety of conditions, particularly infections, and today echinacea products are among the best-selling herbal preparations in several developed countries. Modern interest in echinacea is focused on its immunomodulatory effects, particularly in the prevention and treatment of upper respiratory tract infections. The chemistry of Echinacea species is well documented, and several groups of constituents, including alkamides and caffeic acid derivatives, are considered important for activity. There are, however, differences in the constituent profile of the three species. Commercial echinacea samples and marketed echinacea products may contain one or more of the three species, and analysis of samples of raw material and products has shown that some do not meet recognized standards for pharmaceutical quality. Evidence from preclinical studies supports some of the traditional and modern uses for echinacea, particularly the reputed immunostimulant (or immunomodulatory) properties. Several, but not all, clinical trials of echinacea preparations have reported effects superior to those of placebo in the prevention and treatment of upper respiratory tract infections. However, evidence of efficacy is not definitive as studies have included different patient groups and tested various different preparations and dosage regimens of echinacea. On the basis of the available limited safety data, echinacea appears to be well tolerated. However, further investigation and surveillance are required to establish the safety profiles of different echinacea preparations. Safety issues include the possibility of allergic reactions, the use of echinacea by patients with autoimmune diseases and the potential for echinacea preparations to interact with conventional medicines.

(2) Dogan Z, Ergul B, Sarikaya M, Filik L, Gonultas MA, Hucumenoglu S, Can M. The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid. Bratisl Lek Listy. 2014;115(7):411-5. doi: 10.4149/bll_2014_081. 

Abstract. Background: Ulcerative colitis is a chronic inflammatory condition of the colon, and reactive oxidative metabolites (ROMs) play an important role in its pathogenesis. Alternative therapies such as herbal remedies are increasingly being used in the treatment of ulcerative colitis for better clinical outcome of ulcerative colitis and less adverse effects. Echinacea has many features including antioxidant and wound-healing properties. Hence, the present study was undertaken to evaluate the protective effect of Echinacea spp. on experimental colitis model induced by acetic acid in Wistar albino rats....Conclusion: Echinacea may possibly have some therapeutic usefulness in the management of ulcerative colitis