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Description

Al222
Al222 (25124 pt) 2026-Aug-14 09:12

Echinacea Angustifolia Meristem Cell Culture is a naturally derived compound from the plant Echinacea Angustifolia belonging to the Asteraceae family.

Industrial Production Process

The production of Echinacea Angustifolia meristem cell cultures, used in cosmetics and herbal medicine for their high antioxidant, anti-inflammatory, and immune-stimulating properties, employs advanced plant biotechnology techniques. These cultures are derived from meristematic tissue, which is rich in plant stem cells. Here is a detailed overview of the process.

Selection. The process begins with the selection of meristematic tissues from healthy Echinacea Angustifolia plants. These tissues are sterilized to remove any microbial contaminants and prepared for in vitro cultivation.

Culture Initiation. The meristematic tissues are placed in a specific culture medium that promotes the proliferation of plant stem cells. This medium is enriched with plant hormones, nutrients, and growth factors to optimize cell development.

Growth. The meristem cultures are maintained under controlled light and temperature conditions to promote cell growth and differentiation. During this phase, the cultures can be monitored and adjusted to maximize the production of active principles.

Harvesting. Once the cultures have reached an optimal cell density, they are harvested for the extraction of bioactive compounds. Extraction can be performed using gentle methods that preserve the integrity and activity of the extracted active principles.

Purification . The obtained extracts are purified to remove any impurities and concentrated to increase the level of active ingredients. This may include techniques such as filtration, chromatography, and vacuum evaporation.

Quality Control. The Echinacea Angustifolia meristem cell culture extracts undergo rigorous quality control tests to confirm the presence, purity, and concentration of bioactive compounds, as well as to ensure the absence of contaminants. These tests can include chromatographic analyses, spectroscopic analyses, and biological activity tests.

Form and Color. Echinacea Angustifolia meristem cell culture appears as a colorless or pale-colored liquid, with a consistency that can vary depending on its concentration and the culture medium used.

What it is for and where

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS   84696-11-7

EC number   283-631-6

Applications. It is used in a variety of skincare products, including serums, creams, and lotions, for its ability to stimulate cell renewal and improve the health and appearance of the skin.

Benefits. It promotes collagen production, helping to reduce fine lines and wrinkles, and provides a soothing and protective effect against external agents, contributing to the maintenance of youthful and radiant skin.

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Echinacea Angustifolia, also known as narrow-leaved coneflower, is a perennial plant in the Asteraceae family. Native to North America, it is well-known for its medicinal properties, particularly for boosting the immune system.

Chemical Composition

The plant contains a variety of bioactive compounds, including alkylamides, polysaccharides, and phenolic compounds, which provide immunomodulatory, antioxidant, and antimicrobial properties.

Activities.

Extracts of Echinacea Angustifolia have shown significant antioxidant and anti-inflammatory effects. Research has highlighted its potential in enhancing immune response and reducing inflammation.

Therapeutic Potential.

Traditionally, Echinacea Angustifolia has been used to treat colds, flu, and other respiratory infections, as well as being used to strengthen the body's natural defenses.

Applications.

Extracts of Echinacea Angustifolia are used in the production of dietary supplements and pharmaceutical products due to their health-beneficial properties. They are also used in the cosmetic industry for their beneficial skin properties.

References_____________________________________________________________________

(1) Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005 Aug;57(8):929-54. doi: 10.1211/0022357056127. PMID: 16102249.

Abstract. This paper reviews the chemistry, pharmacology and clinical properties of Echinacea species used medicinally. The Echinacea species Echinacea angustifolia, Echinacea pallida and Echinacea purpurea have a long history of medicinal use for a variety of conditions, particularly infections, and today echinacea products are among the best-selling herbal preparations in several developed countries. Modern interest in echinacea is focused on its immunomodulatory effects, particularly in the prevention and treatment of upper respiratory tract infections. The chemistry of Echinacea species is well documented, and several groups of constituents, including alkamides and caffeic acid derivatives, are considered important for activity. There are, however, differences in the constituent profile of the three species. Commercial echinacea samples and marketed echinacea products may contain one or more of the three species, and analysis of samples of raw material and products has shown that some do not meet recognized standards for pharmaceutical quality. Evidence from preclinical studies supports some of the traditional and modern uses for echinacea, particularly the reputed immunostimulant (or immunomodulatory) properties. Several, but not all, clinical trials of echinacea preparations have reported effects superior to those of placebo in the prevention and treatment of upper respiratory tract infections. However, evidence of efficacy is not definitive as studies have included different patient groups and tested various different preparations and dosage regimens of echinacea. On the basis of the available limited safety data, echinacea appears to be well tolerated. However, further investigation and surveillance are required to establish the safety profiles of different echinacea preparations. Safety issues include the possibility of allergic reactions, the use of echinacea by patients with autoimmune diseases and the potential for echinacea preparations to interact with conventional medicines.

(2) Dogan Z, Ergul B, Sarikaya M, Filik L, Gonultas MA, Hucumenoglu S, Can M. The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid. Bratisl Lek Listy. 2014;115(7):411-5. doi: 10.4149/bll_2014_081. 

Abstract. Background: Ulcerative colitis is a chronic inflammatory condition of the colon, and reactive oxidative metabolites (ROMs) play an important role in its pathogenesis. Alternative therapies such as herbal remedies are increasingly being used in the treatment of ulcerative colitis for better clinical outcome of ulcerative colitis and less adverse effects. Echinacea has many features including antioxidant and wound-healing properties. Hence, the present study was undertaken to evaluate the protective effect of Echinacea spp. on experimental colitis model induced by acetic acid in Wistar albino rats....Conclusion: Echinacea may possibly have some therapeutic usefulness in the management of ulcerative colitis