Hello, Guest!
 
 

🔍
REVIEW

Description

Al222
Al222 (25124 pt) 2024-Feb-23 16:52

Echinacea Angustifolia Root Cell Culture Extract is a naturally derived compound from the plant Echinacea Angustifolia belonging to the Asteraceae family.

Industrial Production Process

The production of Echinacea Angustifolia root cell culture extract, an innovative ingredient used in cosmetics for its antioxidant, regenerative, and skin-protective properties, follows an advanced biotechnological process. This approach utilizes in vitro cell culture techniques to maximize the production of specific active ingredients. Here is a detailed overview of the process.

  • Culture Initiation. The process begins with the selection and preparation of Echinacea Angustifolia root tissues, which are sterilized and placed in an appropriate culture medium under aseptic conditions to promote the growth of callus cells.
  • Callus Growth. The callus cells, a mass of undifferentiated plant cells, are cultivated in incubators with controlled conditions of light, temperature, and humidity. During this phase, plant hormones and nutrients may be added to the culture medium to stimulate growth and optimize the production of active principles.
  • Active Ingredient Extraction. Once the callus cultures have reached an optimal density, they are harvested and subjected to extraction to isolate the bioactive compounds. Extraction can be performed using solvents such as ethanol or water, or through gentler extraction methods to preserve the integrity of the compounds.
  • Purification and Concentration. The obtained extract is filtered to remove cellular residues and then concentrated under vacuum or through other methods to reduce solvent content and increase the concentration of active ingredients.
  • Quality Control. The Echinacea Angustifolia root cell culture extract undergoes quality control checks to verify the presence and concentration of bioactive compounds, as well as the absence of contaminants. These tests can include analytical techniques such as high-performance liquid chromatography (HPLC), spectroscopy, and microbiological analyses.

Form and Color. Echinacea Angustifolia root cell culture extract appears as a colorless or slightly yellow liquid, with a consistency that varies based on concentration.

What it is for and where

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS   84696-11-7

EC number   283-631-6

Applications. Predominantly used in serums, creams, and anti-aging treatments for its ability to promote collagen production and improve skin elasticity.

________________________

Echinacea Angustifolia, also known as narrow-leaved coneflower, is a perennial plant in the Asteraceae family. Native to North America, it is well-known for its medicinal properties, particularly for boosting the immune system.

Chemical Composition

The plant contains a variety of bioactive compounds, including alkylamides, polysaccharides, and phenolic compounds, which provide immunomodulatory, antioxidant, and antimicrobial properties.

Activities.

Extracts of Echinacea Angustifolia have shown significant antioxidant and anti-inflammatory effects. Research has highlighted its potential in enhancing immune response and reducing inflammation.

Therapeutic Potential.

Traditionally, Echinacea Angustifolia has been used to treat colds, flu, and other respiratory infections, as well as being used to strengthen the body's natural defenses.

Applications.

Extracts of Echinacea Angustifolia are used in the production of dietary supplements and pharmaceutical products due to their health-beneficial properties. They are also used in the cosmetic industry for their beneficial skin properties.

References_____________________________________________________________________

(1) Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005 Aug;57(8):929-54. doi: 10.1211/0022357056127. PMID: 16102249.

Abstract. This paper reviews the chemistry, pharmacology and clinical properties of Echinacea species used medicinally. The Echinacea species Echinacea angustifolia, Echinacea pallida and Echinacea purpurea have a long history of medicinal use for a variety of conditions, particularly infections, and today echinacea products are among the best-selling herbal preparations in several developed countries. Modern interest in echinacea is focused on its immunomodulatory effects, particularly in the prevention and treatment of upper respiratory tract infections. The chemistry of Echinacea species is well documented, and several groups of constituents, including alkamides and caffeic acid derivatives, are considered important for activity. There are, however, differences in the constituent profile of the three species. Commercial echinacea samples and marketed echinacea products may contain one or more of the three species, and analysis of samples of raw material and products has shown that some do not meet recognized standards for pharmaceutical quality. Evidence from preclinical studies supports some of the traditional and modern uses for echinacea, particularly the reputed immunostimulant (or immunomodulatory) properties. Several, but not all, clinical trials of echinacea preparations have reported effects superior to those of placebo in the prevention and treatment of upper respiratory tract infections. However, evidence of efficacy is not definitive as studies have included different patient groups and tested various different preparations and dosage regimens of echinacea. On the basis of the available limited safety data, echinacea appears to be well tolerated. However, further investigation and surveillance are required to establish the safety profiles of different echinacea preparations. Safety issues include the possibility of allergic reactions, the use of echinacea by patients with autoimmune diseases and the potential for echinacea preparations to interact with conventional medicines.

(2) Dogan Z, Ergul B, Sarikaya M, Filik L, Gonultas MA, Hucumenoglu S, Can M. The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid. Bratisl Lek Listy. 2014;115(7):411-5. doi: 10.4149/bll_2014_081. 

Abstract. Background: Ulcerative colitis is a chronic inflammatory condition of the colon, and reactive oxidative metabolites (ROMs) play an important role in its pathogenesis. Alternative therapies such as herbal remedies are increasingly being used in the treatment of ulcerative colitis for better clinical outcome of ulcerative colitis and less adverse effects. Echinacea has many features including antioxidant and wound-healing properties. Hence, the present study was undertaken to evaluate the protective effect of Echinacea spp. on experimental colitis model induced by acetic acid in Wistar albino rats....Conclusion: Echinacea may possibly have some therapeutic usefulness in the management of ulcerative colitis