Dipeptide diaminobutyroyl benzylamide diacetate: properties, uses, pros, cons, safety

Dipeptide diaminobutyroyl benzylamide diacetate is a chemical compound primarily used in cosmetics and skincare products.

The name describes the structure of the molecule:

• Dipeptide indicates that the compound is a dipeptide, which is a molecule made up of two amino acids linked together by a peptide bond. Dipeptides are used in cosmetics for their beneficial properties on the skin.
• diaminobutyroyl refers to a chemical structure derived from 4-aminobutyric acid. This structure is part of the dipeptide and contributes to its properties.
• benzylamide is a functional group that contains a benzene ring attached to an amide group. This group imparts specific chemical and biological properties to the compound.
• diacetate indicates that the compound contains two acetate groups. These groups can affect the solubility and stability of the compound.

Origin. Synthetically manufactured in the laboratory, this dipeptide is inspired by active components found in snake venom.

Functions of Raw Materials.

Synthetic Peptide. Acts by relaxing facial muscles, thereby reducing the appearance of wrinkles and providing a smoothing effect on the skin.

Industrial Production Process

• Chemical Synthesis. The peptide is synthesized through controlled chemical processes to ensure its purity and efficacy.
• Purification. After synthesis, the peptide is purified to remove any impurities.
• Quality Control. Each batch of the dipeptide undergoes rigorous quality testing to ensure its safety and efficacy.

What it is for and where

Dipeptide diaminobutyroyl benzylamide diacetate, also known as Syn-Ake, is a popular ingredient in the cosmetic industry, especially in anti-aging products. It is a synthetic peptide that mimics the action of snake venom and is used for its relaxing properties on muscles, helping to reduce wrinkles and expression lines (1). It is known for its muscle-relaxing properties. It is often used in anti-aging products to reduce the appearance of fine lines and wrinkles, acting similarly to Botox but in a non-invasive manner. It helps to relax facial muscles, thereby reducing wrinkles caused by facial expressions.

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Form and Color

Dipeptide diaminobutyroyl benzylamide diacetate appears as a clear and colorless liquid.

References_____________________________________________________________________

(1) Trookman NS, Rizer RL, Ford R, Ho E, Gotz V. Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J Clin Aesthet Dermatol. 2009 Mar;2(3):38-43. PMID: 20729942; PMCID: PMC2923951.

Abstract. Objective: To evaluate the efficacy and tolerance of a novel line treatment for periocular and perioral wrinkles. The line treatment was formulated with multiple growth factors, antioxidants, and a collagen-building peptide—ingredients that have been shown to increase collagen levels and provide long-term aesthetic benefits. To help provide immediate smoothing effects, hyaluronic acid filling spheres and a muscle contraction-inhibiting peptide were also included in the formulation....Conclusions: The results from this study demonstrate that this uniquely formulated line treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles.

Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327-345.

Abstract. Ageing, a basic biological process seen in all living creatures, is not preventable. Surgical and topical modalities have been invented and substances were applied topically to alter the ageing process. Peptides and proteins, frequently used for this purpose, were categorized into four groups: signal peptides, enzyme-inhibitor peptides, neurotransmitter-inhibitor peptides and carrier peptides. We comprehensively review eligible studies -including controlled ex vivo or in vivo efficacy studies on any topical peptide or protein that has been administered to treat signs and symptoms of ageing.