Copper complexes of chlorophyll is a chemical compound, a semi-synthetic mixture of the water-soluble sodium salt of copper chlorophyllin. It is obtained from herbs, nettles and other plants. It is a green dye.

There are 2 other designations for this component :

• E141 (i) Copper pheophytin
• E141 (ii) Sodium or potassium salts of chlorophyll complexes with copper

The synthesis process takes place in several stages:

• Chlorophyll extraction. Chlorophyll is first extracted from plants, spinach or nettles, using a solvent such as acetone or ethanol.
• Conversion to Clorophylline. The extracted chlorophyll is converted to water-soluble Chlorophyllin by replacing the magnesium ion in the center of the molecule with a hydrogen ion. This is typically done by adding an acid to the chlorophyll solution.
• Complexion with Copper. Chlorophyllin is released in a reaction with a copper salt, such as copper sulfate, to form the copper complex. This reaction involves the formation of a coordinate bond between the copper ion and the Clorofillin molecule.
• Purification. The reaction mixture is purified to isolate the copper complexes of chlorophylls and chlorophylls. This typically involves processes such as filtration and drying.
• Quality control test. The final product is tested to ensure it meets the required specifications. This may involve testing for color intensity, purity, and other physical and chemical properties.

What it is used for and where

The concentration of copper does not reach toxic levels, however a maximum daily intake of 15mg per kg/body weight is recommended (1).

Medical

This clinical study demonstrates a statistically significant improvement in the repair of photo-aged skin by topical treatment with a test formulation containing a 0.05% liposomal dispersion of Copper Chlorophyll Complexes (1).

Copper Chlorophyll Complexes has been used topically for many years as a treatment for wound healing (2) but has also demonstrated inhibition of hyaluronidase activity in vitro, supporting the concept that topical application of this component may be useful in reversing age-related reductions in hyaluronic acid, acting to improve the appearance of facial skin (3).

"Copper Chlorophyll Complexes  studies"

Molecular Formula : C₃₄H₃₁CuN₄Na₃O₆

PMolecular Weight: 724.159 g/mol

CAS: 15611-43-5

Synonyms :

• E141
• Natural green 3
• Chlorophyllin copper sodium salt
• Chlorophyllin, potassium, sodium, and copper metallo-complex
• Potassium sodium copper chlorophyllin
• EINECS 234-242-5
• Copper sodium chlorophyllin

References_____________________________________________________________________

(1) McCook JP, Stephens TJ, Jiang LI, Law RM, Gotz V. Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix. Clin Cosmet Investig Dermatol. 2016 Jul 25;9:167-74. doi: 10.2147/CCID.S111139

(2) Smith RG. Enzymatic debriding agents: an evaluation of the medical literature. Ostomy Wound Manage. 2008

(3) McCook JP, Dorogi PL, Vasily DB, Cefalo DR. In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs. Clin Cosmet Investig Dermatol. 2015 Aug 12;8:443-8. doi: 10.2147/CCID.S86863.