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admin (19653 pt) 2026-Feb-28 12:03

Orthosiphon Stamineus Leaf Extract (Orthosiphon stamineus): properties, uses, pros, cons, safety

Orthosiphon Stamineus Leaf Extract is a botanical extract obtained from the leaves of Orthosiphon stamineus (family Lamiaceae), a plant also known as java tea / cat’s whiskers. In cosmetics it is mainly used as a skin conditioning ingredient, with formulation interest linked to its polyphenolic fraction (e.g., rosmarinic acid) and methoxylated flavonoids (e.g., sinensetin, eupatorin), whose presence and levels strongly depend on the extraction process and standardization.

Definition

It is a cosmetic ingredient of plant origin consisting of a complex mixture of natural compounds extracted from the leaf matrix. The qualitative profile depends on critical process variables: solvent (water, ethanol, hydroalcoholic blends, glycols/glycerin), drug/solvent ratio, temperature, time, and clarification/concentration steps. For reliable use in formulation, specifications and (when applicable) standardization to analytical markers are key.

Production process

A typical supply chain includes: selection and cleaning of leaves, controlled drying, milling, extraction (aqueous / hydroalcoholic / glycolic), filtration and clarification, concentration (often under vacuum), optional standardization to markers, and final stabilization (ready-to-use solution or powder via drying). In cosmetics, quality control focuses on microbiological load, contaminants (e.g., heavy metals), batch-to-batch consistency (color/odor/markers), and the verification of residual solvents when relevant.

Key constituents

Representatively, the extract may contain (in variable proportions): rosmarinic acid (polyphenol), sinensetin and eupatorin (methoxylated flavonoids), and a fraction of characteristic diterpenes (often cited as orthosiphols/related derivatives). In general, hydroalcoholic extractions or selected organic solvents may enrich some fractions (e.g., methoxylated flavonoids) compared to purely aqueous extractions.

Phytochemical analysis shows polyphenols, bioactive proteins, flavonol glycosides and a lot of potassium with anti-inflammatory, antioxidant, antibacterial and vasodilator activity (1).

Identification data and specifications

ParameterValueNote
INCI nameOrthosiphon Stamineus Leaf Extractlabel denomination
Originplantfrom Orthosiphon stamineus (Lamiaceae)
Plant part usedleavesbotanical raw material
CAS number84012-29-3commonly reported identifier
EC number (EINECS/ELINCS)281-674-5EU identifier
Cosmetic functionskin conditioningmain function in ingredient databases
Commercial formliquid or powderdepends on grade (solution/glycolic/powder)
Typical solvents/carrierswater, ethanol, glycerin/glycolsdepending on finished product


Physico-chemical properties (indicative)

ParameterIndicative valueNote
Appearanceliquid or powderdepends on standardization and carrier
Coloryellow–browninfluenced by polyphenols and concentration
Odormild, herbalvaries with solvent and purity
Solubilitygood in water/glycerin/glycols (if hydrophilic)depends on form and carrier
Stabilitysensitive to light and oxidationpossible color/odor drift over time
Formulation pH rangegenerally compatible with skin pHverify marker stability
Interactionspossible interactions with polymers/cationicsmore likely at high polyphenol content


Functional role and rationale of use

In cosmetics, its use is consistent with a skin conditioning contribution and support for comfort. From a technical perspective, the phenolic fraction can be leveraged in formulas with “botanical” positioning, including narratives linked to an antioxidant profile of the finished formula. Perceivable outcomes depend on dosage, stability (oxidation/photo-stability), and the delivery system (emulsion, gel, lotion).

Main uses

Orthosiphon Stamineus is used in traditional medical medicine as a treatment for rheumatism, inflammation of the kidneys and urinary tract, kidney stones and to reduce LDL cholesterol and blood pressure.

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment by restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants.

In practice, it is found in:

  • Face care: “comfort” creams/serums, formulas targeting dull/tired-looking skin, products with botanical storytelling.

  • Body care: light lotions and gels where “botanical care” positioning and good sensorial profile are desired.

  • Functional/claim-driven products: formulas where marker consistency (when declared) supports profile repeatability.

In practice, it is found in:

  • Face care: “comfort” creams/serums, formulas targeting dull/tired-looking skin, products with botanical storytelling.

  • Body care: light lotions and gels where “botanical care” positioning and good sensorial profile are desired.

  • Functional/claim-driven products: formulas where marker consistency (when declared) supports profile repeatability.

Bibliografia__________________________________________________________________________

(1) Ashraf K, Sultan S, Adam A. Orthosiphon stamineus Benth. is an Outstanding Food Medicine: Review of Phytochemical and Pharmacological Activities. J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):109-118. doi: 10.4103/jpbs.JPBS_253_17.

Abstract. Orthosiphon stamineus Benth. (Lamiaceae) is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have demonstrated the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory activies. This review is a comprehensive summary of the presently available chemical, pharmacological investigations as well as the traditional and therapeutic uses of this plant. Important and different experimental data have been addressed along with a review of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.

Wang Q, Wang J, Li N, Liu J, Zhou J, Zhuang P, Chen H. A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications. Molecules. 2022 Jan 10;27(2):444. doi: 10.3390/molecules27020444. 

Abstract. (1) Background: Orthosiphon stamineus Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of O. stamineus in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to O. stamineus and diabetes were included. The mechanisms of O. stamineus in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in O. stamineus. (4) Conclusion: O. stamineus could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.

Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. J Med Food. 2012 Aug;15(8):678-90. doi: 10.1089/jmf.2011.1973. 

Abstract. Orthosiphon stamineus Benth. (Lambiaceae) is an important plant in traditional folk medicine. This review is a comprehensive summary of the currently available chemical, pharmacological, and toxicological investigations as well as the traditional and therapeutic uses of this plant. Different in vitro and in vivo models have been addressed along with a survey of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. Previous studies revealed that O. stamineus possesses several pharmacological activities, which are attributed to its phytochemical content. It was found that O. stamineus exhibits diuretic, hypouricemic, renal protective, antioxidant, anti-inflammatory, hepatoprotective, gastroprotective, antihypertensive, antidiabetic, antihyperlipidemic, antimicrobial, and anorexic activities. In conclusion, O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.