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admin (19653 pt) 2026-Feb-28 11:48

Orthosiphon Stamineus Extract (Orthosiphon stamineus): properties, uses, pros, cons, safety

Orthosiphon Stamineus Extract is an extract obtained from the leaves of Orthosiphon stamineus (family Lamiaceae), a plant also known as java tea or cat’s whiskers. In cosmetics it is mainly used as a skin conditioning ingredient and, depending on the extraction method, it can be valued for its content of polyphenols and methoxylated flavonoids. In herbal practice, Orthosiphon leaf preparations are traditionally associated with supporting urinary function (a phytotherapeutic use context, distinct from cosmetics).

 

Definition

It is a botanical extract (a complex mixture) obtained from dried or fresh leaves, with a composition profile that depends on: botanical source, raw material quality, extraction solvent (water, ethanol, or hydroalcoholic mixtures), drug/solvent ratio, temperature, and processing time. It is therefore not a single molecule: quality depends on standardization (analytical markers) and batch-to-batch consistency.

Production process

A typical manufacturing chain includes: leaf selection and cleaning, controlled drying, milling, extraction (aqueous or hydroalcoholic), clarification/filtration, concentration (often under vacuum), possible standardization to markers (e.g., specific polyphenols), and final stabilization (solution, glycolic extract, or powder via spray-drying). For cosmetic applications, key controls include microbiological purity, solvent residues, heavy metals, and marker consistency.

Key constituents

Representatively, the extract may contain: rosmarinic acid (a polyphenol), sinensetin and eupatorin (flavonoids), and a fraction of diterpenes (e.g., orthosiphols, when present). The real profile varies significantly with the solvent: hydroalcoholic extracts tend to concentrate certain phenolic fractions more than purely aqueous extracts.

Identification data and specifications

CharacteristicValueNote
INCI nameOrthosiphon Stamineus Extractcosmetic denomination
Plant part usedleavesas per ingredient repertories
Originbotanicalextract of Orthosiphon stamineus (Lamiaceae)
CAS number84012-29-3commonly reported identifier
EC number (EINECS)281-674-5EU identifier
Typical cosmetic functionskin conditioningprimary database function


Physicochemical properties (indicative)

CharacteristicIndicative valueNote
Appearanceliquid (glycolic/hydroalcoholic) or powderdepends on commercial grade
Coloryellow–browndepends on polyphenols and concentration
Odormild, herbaldepends on solvent and purity
Solubilitygood in water and/or glycols (if hydrophilic extract)depends on form (solution vs powder)
Stabilitysensitive to light and oxidationpackaging and antioxidants can help
Practical formulation pH rangegenerally compatible with skin pHverify for marker stability
Interactionspossible complexation with polymers/cationicsdepends on matrix and polyphenol level


Functional role and mechanism of action

In cosmetics, its use is consistent with skin conditioning: improving comfort, supporting a perception of more “even” skin, and contributing to the sensory profile of the finished product. From a technical perspective, polyphenols may be positioned within an antioxidant-support narrative; real-world transferability depends on dose, marker stability, and the delivery system.

Main uses

Orthosiphon Stamineus is used in traditional medical medicine as a treatment for rheumatism, inflammation of the kidneys and urinary tract, kidney stones and to reduce LDL cholesterol and blood pressure.

Phytochemical analysis shows polyphenols, bioactive proteins, flavonol glycosides and a lot of potassium with anti-inflammatory, antioxidant, antibacterial and vasodilator activity (1).

Cosmetics - INCI Functions

Skin conditioning agent. It is the mainstay of topical skin treatment by restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants.

Supplements and herbal teas (use context): Orthosiphon leaf preparations are traditionally used to support diuresis and urinary tract function; for oral-use extracts, standardization and local regulatory compliance are critical.

Pros and cons

Pros
Can support a botanical and polyphenol-based positioning.
Good versatility: available as glycolic extract, hydroalcoholic extract, or powder, with relatively straightforward incorporation into many bases.
Contributes to skin conditioning without heavy sensorial impact when properly dosed.

Cons
Batch variability if standardization is lacking (clear markers/specifications needed).
Potential instability of some markers to light and oxidation, impacting color/odor over time.
In complex systems, polyphenols may interact (e.g., color shifts or compatibility issues with some polymers), so formulation checks are needed.

Safety, regulatory, and environmental aspects

Safety profile (practical)
In cosmetics, the core issue is extract quality (microbiology, solvent residues, contaminants) and finished-product compatibility for sensitive skin. Botanical extracts, while often well tolerated, can cause irritation in predisposed individuals if the product is rich in solvents, fragrance, or if the extract is highly concentrated.

Allergen
Not a classic fragrance allergen. However, as with many botanical extracts, individual sensitization cannot be excluded; in practice, the evaluation must be made on the finished product.

Contraindications and cautions
For cosmetic use: caution in periocular formulas and on highly compromised skin barrier, especially if the extract is in alcoholic vehicles or at high concentration. For oral use (if relevant): Orthosiphon preparations are associated with a diuretic effect and may require caution with diuretic therapies or renal conditions, in line with phytotherapeutic guidance.

Conclusion

Orthosiphon Stamineus Extract is a leaf extract from Orthosiphon stamineus (Lamiaceae) used mainly for skin conditioning, with formulation interest related to polyphenols and flavonoids. Technical value depends on standardization and in-formula stability; key watch-outs are managing batch variability, light/oxidation stability, and finished-product tolerability.

Bibliografia__________________________________________________________________________

(1) Ashraf K, Sultan S, Adam A. Orthosiphon stamineus Benth. is an Outstanding Food Medicine: Review of Phytochemical and Pharmacological Activities. J Pharm Bioallied Sci. 2018 Jul-Sep;10(3):109-118. doi: 10.4103/jpbs.JPBS_253_17.

Abstract. Orthosiphon stamineus Benth. (Lamiaceae) is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have demonstrated the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory activies. This review is a comprehensive summary of the presently available chemical, pharmacological investigations as well as the traditional and therapeutic uses of this plant. Important and different experimental data have been addressed along with a review of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.

Wang Q, Wang J, Li N, Liu J, Zhou J, Zhuang P, Chen H. A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications. Molecules. 2022 Jan 10;27(2):444. doi: 10.3390/molecules27020444. 

Abstract. (1) Background: Orthosiphon stamineus Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of O. stamineus in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to O. stamineus and diabetes were included. The mechanisms of O. stamineus in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in O. stamineus. (4) Conclusion: O. stamineus could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.

Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. J Med Food. 2012 Aug;15(8):678-90. doi: 10.1089/jmf.2011.1973. 

Abstract. Orthosiphon stamineus Benth. (Lambiaceae) is an important plant in traditional folk medicine. This review is a comprehensive summary of the currently available chemical, pharmacological, and toxicological investigations as well as the traditional and therapeutic uses of this plant. Different in vitro and in vivo models have been addressed along with a survey of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. Previous studies revealed that O. stamineus possesses several pharmacological activities, which are attributed to its phytochemical content. It was found that O. stamineus exhibits diuretic, hypouricemic, renal protective, antioxidant, anti-inflammatory, hepatoprotective, gastroprotective, antihypertensive, antidiabetic, antihyperlipidemic, antimicrobial, and anorexic activities. In conclusion, O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.