CI 47000 è un composto chimico, un colorante sintetico conosciuto anche con il nome di D&C Yellow No. 11, Solvent Yellow 33

Nome chimico:  2-quinolin-2-ylindene-1,3-dione

A cosa serve e dove si usa

Cosmetica

Ingrediente cosmetico soggetto a restrizioni  IV/81 (CI 47000) (colorant) II/1358 (Solvent Yellow 33; CI 47000): when used as a substance in hair dye products) come Voce pertinente negli allegati del regolamento europeo sui cosmetici n. 1223/2009. Sostanza o ingrediente segnalato: 

• 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline

Cosmetica - Funzioni INCI

Colorante. Questo ingrediente ha la funzione di colorare la soluzione in cui è inserito in modo temporaneo, semi-permanente o permanente, sia da solo che in presenza dei componenti complementari aggiunti per la colorazione.

Tintura per capelli. E' un ingrediente che aggiunge ai capelli una colorazione che può essere temporanea, semi-permanente o permanente a seconda di quali altri ingredienti vengono aggiunti per ottenere il risultato. Il pH per la tintura dei capelli è generalmente compreso tra 9 e 10.

Sicurezza

E' un ingrediente che ha qualche controindicazione importante riguardante il profilo salutare: non deve entrare in contatto con le mucose.

Su questo colorante si sono concentrati alcuni studi che ne hanno rilevato la pericolosità (1). 

Molecular Formula    C₁₈H₁₁NO₂

Molecular Weight    273.3 g/mol

CAS   8003-22-3

EC number  232-318-2

UNII 44F3HYL954

DTXSID00873130

Synonyms: 

Solvent Yellow 33

D&C Yellow No. 11

Bibliografia_____________________________________________________________________

(1) National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of D&C Yellow No. 11 (CAS No. 8003-22-3) in F344/N Rats (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1997 Apr;463:1-190. PMID: 12587013.

Abstract. .... Exposure of rats to D&C Yellow No. 11 in feed for 2 years resulted in increased incidences of nonneoplastic liver lesions including clear cell foci, increased basophilia and granularity in the cytoplasm of hepatocytes, and bile duct, hepatocyte, and Kupffer cell pigmentation in males and females and mixed cell foci in males. In the kidney, there were increased incidences of renal tubule pigmentation and transitional epithelial hyperplasia in males and females and renal tubule hyperplasia in males. The severity of nephropathy was increased in exposed males and females. Synonyms: 2-(2-Quinolinyl)-1H-indene-1,3-(2H)-dione; 2-(2-quinolyl)-1,3-indandione Trade names: Arlosol Yellow S, Chinoline Yellow D (soluble in spirits), Chinoline Yellow ZSS, C.I. 47000, C.I. Solvent Yellow 33, Nitro Fast Yellow SL, Oil Yellow SIS, Petrol Yellow C, Quinoline Yellow A Spirit Soluble, Quinoline Yellow Base, Quinoline Yellow Spirit Soluble, Quinoline Yellow SS, Solvent Yellow 33, Waxoline Yellow T

Eastin WC, Elwell MR, Grumbein S, Yuan JH. Effects of D&C yellow no. 11 ingestion on F344/N rats and B6C3F1 mice. J Toxicol Environ Health. 1996 Jun 7;48(2):197-213. doi: 10.1080/009841096161438.

Abstract. ....Microscopic lesions in the liver and kidney of the pups in all dose groups were similar to those described in the 13-wk study. The results of these studies indicate that compound-related effects occurred at all dietary concentrations of D&C yellow no. 11. Liver weights were increased in dosed rats and mice, minimal to mild hepatocellular degeneration was seen in rats receiving dietary concentrations of 1700 ppm and above and in mice at 5000 ppm and above, and there was an increase in the number and size of hyaline droplets in all dosed groups of male rats. Similar compound-related effects were also seen in all dosed rats in the perinatal toxicity study. With the exception of pigment accumulation, the treatment-related kidney and liver lesions in male rats were reversible by 14 d after chemical was withdrawn from the diet.