2-Amino-4-hydroxyethylaminoanisole sulfate is a chemical compound synthesised in 6 rather complex steps using 4-methoxyanilines, acetic anhydride, sulphuric acid, nitric acid, hydrochloric acid, potassium hydroxide.
The name describes the structure of the molecule.
- 2-Amino indicates the presence of an amino group (NH2) at the 2nd position of the molecule.
- 4-hydroxyethylamino suggests the presence of an ethylamino group with a hydroxy group at the 4th position.
- anisole refers to the anisole aromatic core of the molecule.
- sulfate indicates that the molecule is present as a salt of sulfuric acid.
Function of the Components
2-Amino-4-hydroxyethylaminoanisole sulfate. It is commonly used as a dye in hair coloring products.
Raw Materials Used in Production.
- Anisole: An aromatic organic compound often used as a starting point in chemical synthesis.
- Aminating agents: To introduce amino groups into the molecule.
- Sulfuric acid: Used to introduce the sulfate group into the final molecule.
Step-by-step Summary of Industrial Production Process.
- Preparation of Anisole. Anisole is purified and readied for reaction.
- Amination. Amino groups are introduced into the molecule.
- Introduction of Sulfate Group. Sulfuric acid is used to convert the final molecule into a sulfate salt.
- Purification. Removal of impurities through various purification processes.
Form and Color.
2-Amino-4-hydroxyethylaminoanisole sulfate is a brownish solid powder.

What it is used for and where
Cosmetics
Coupling agent. It is an ingredient that plays the role of a 'coupling component' in oxidation colours and reacts with a precursor when an oxidising agent is present.
CAS: 83763-48-8
Commercial Applications
Often used as an intermediate in the production of hair dyes.
Safety
2-Amino-4-hydroxyethylaminoanisole sulfate is generally considered safe, but should be avoided in cosmetic products where the compound N-nitroso, a carcinogen that interacts with nitrites and nitrosamines, may be formed (1).
2-Amino-4-hydroxyethylaminoanisole sulfate is considered a rare and novel contact allergen (2).