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admin (19653 pt) 2024-Oct-14 16:28

Garcinia Mangostana Amino Acids, extracted from the mangosteen fruit (Garcinia mangostana), are bioactive compounds that play a vital role in cellular nutrition and skin health. Mangosteen is well known for its powerful antioxidant benefits, and the amino acids present in the fruit are used in cosmetic products to improve hydration, cell regeneration, and provide nourishment to the skin. These amino acids contribute to the structure and function of skin proteins, enhancing skin elasticity and resilience.

Chemical Composition and Structure

The amino acids derived from Garcinia Mangostana include essential compounds such as glycine, alanine, valine, and lysine. These amino acids are the building blocks of proteins and are crucial for collagen synthesis, a key structural protein for the skin. Their chemical structure features an amino group (-NH2) and a carboxyl group (-COOH), which enable them to participate in cellular regeneration processes and aid in skin hydration.

Physical Properties

Garcinia Mangostana amino acids are typically available as fine powders, soluble in water. Due to their small molecular size, they easily penetrate the skin, enhancing hydration and nourishment at the cellular level. They are odorless and can be readily incorporated into creams, serums, and lotions, providing an immediate nutrient boost to the skin.

Production Process

They are extracted from the fruit using a hydrolysis process or aqueous extraction. During the process, proteins are broken down into their amino acid components, yielding a concentrated and bioactive form suitable for use in cosmetic formulations. The extraction process is designed to preserve the integrity of the amino acids and their efficacy.

  • Harvesting of Raw Materials: The fruits and parts of Garcinia mangostana are sustainably harvested, with particular attention to ensuring the quality of the plant material.

  • Drying: After harvesting, parts of the plant, such as the rind and pulp, are cleaned and subjected to a drying process to remove moisture. This step is crucial for preserving the active properties and facilitating subsequent extraction.

  • Extraction of Amino Acids: The extraction of amino acids occurs using appropriate solvents, such as water or saline solutions. The dried plant parts are immersed in the solvent, and the mixture is agitated or heated to promote the release of amino acids.

  • Filtration: After the extraction process, the obtained solution is filtered to remove undissolved solids, resulting in a liquid extract containing amino acids and other bioactive compounds.

  • Purification: The liquid extract is further purified, often through chromatography techniques, to isolate specific amino acids and ensure a high-purity product.

  • Quality Control and Packaging: Finally, Garcinia mangostana amino acids undergo quality control checks to verify their purity and functional properties. After analysis, they are packaged for distribution and use in dietary supplements and cosmetic products.

Applications

  • Skincare: Used in creams, lotions, and serums to enhance skin hydration and support collagen synthesis. Garcinia Mangostana amino acids are ideal for regenerating damaged skin and improving skin texture.

  • Anti-aging Products: Due to their role in supporting collagen production, these amino acids are commonly used in anti-aging formulations to reduce the appearance of wrinkles and improve skin elasticity.

  • Soothing Products: Their ability to improve hydration and strengthen the skin barrier makes them ideal for products aimed at dry, sensitive, or irritated skin.

INCI Functions:

Hair conditioning agent. A large number of ingredients with specific purposes can co-exist in a hair shampoo: cleansers, conditioners, thickeners, mattifying agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersing agents that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioners includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners.

Skin conditioning agent miscellaneous. Ingredients that have the task of modifying the condition of the skin when it is damaged or dry by reducing its flakiness and restoring its elasticity.

Health and Safety Considerations

Safety in Use
Garcinia Mangostana amino acids are generally considered safe for use in cosmetics. They are well tolerated by the skin and can be used in products for sensitive skin. Major regulatory authorities such as the European Union and the FDA permit their use in cosmetics.

Allergic Reactions
Allergic reactions to Garcinia Mangostana amino acids are extremely rare, but as with any natural product, it is recommended to perform a patch test before application to ensure skin tolerance.

Toxicity and Carcinogenicity
They are natural ingredients and widely used in cosmetic products without reports of significant side effects.

Environmental Considerations
The amino acids are derived from a natural and renewable source—the mangosteen fruit—making them eco-friendly and biodegradable. However, it is important to ensure sustainable harvesting practices to protect natural resources and maintain environmental balance.

Regulatory Status
Garcinia Mangostana amino acids are approved for use in cosmetic products by major regulatory authorities, including the European Union and the FDA in the United States. They are widely used in skincare formulations and anti-aging products.

References__________________________________________________________________________

Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011 Nov;11(8):666-77. doi: 10.2174/156652411797536679. 

Abstract. Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.

Barua A, Choudhury P, Mandal S, Panda CK, Saha P. Therapeutic potential of xanthones from Swertia chirata in breast cancer cells. Indian J Med Res. 2020 Sep;152(3):285-295. doi: 10.4103/ijmr.IJMR_1153_18.

Abstract. Background & objectives: Medicinal plants like Swertia chirata are rich sources of different xanthones. This study was aimed to assess the cytotoxic potential of four most abundant xanthones present in S. chirata both in vivo and in vitro in Ehrlich ascites carcinoma (EAC), a mouse transplantable breast carcinoma cell line and two human breast carcinoma cell lines (MCF-7 and MDA-MB-231).....Results: Among all the xanthones tested XD showed IC50at the lowest dose, and normal cells were unaffected at this dose. Survivability of mice increased significantly when treated with XD compared to other xanthones and cisplatin. Significantly increased ROS and LPO were found in cancer cells as a result of XD treatment which was unaltered in normal cell line. XD induced DNA damage and apoptosis in cancer cell lines. Interpretation & conclusions: Our experimental data indicate that XD may potentially act as a chemotherapeutic agent by enhancing ROS in breast cancer cells thereby leading to apoptosis.

Feng Z, Lu X, Gan L, Zhang Q, Lin L. Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis. Molecules. 2020 Jan 30;25(3):598. doi: 10.3390/molecules25030598.

Abstract. Inflammation is the body's self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases. Current therapeutic approaches include mainly non-steroidal anti-inflammatory drugs and glucocorticoids, which are generally of limited effectiveness and severe side-effects. Thus, it is urgent to develop novel effective anti-inflammatory therapeutic agents. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo. Herein, we provide a comprehensive and up-to-date review of xanthones with anti-inflammatory properties, and analyzed their drug likeness, which might be potential therapeutic agents to fight against inflammation-related diseases.

Nauman MC, Johnson JJ. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacol Res. 2022 Jan;175:106032. doi: 10.1016/j.phrs.2021.106032. 

Panda SS, Chand M, Sakhuja R, Jain SC. Xanthones as potential antioxidants. Curr Med Chem. 2013;20(36):4481-507. doi: 10.2174/09298673113209990144. 

Klein-Júnior LC, Campos A, Niero R, Corrêa R, Vander Heyden Y, Filho VC. Xanthones and Cancer: from Natural Sources to Mechanisms of Action. Chem Biodivers. 2020 Feb;17(2):e1900499. doi: 10.1002/cbdv.201900499.